RESUMO
Vlasoulides A and B (1 and 2), a pair of epimeric C32 sesquiterpene lactone dimers, featuring a 5/7/5/5/(5)/7 ring system were isolated from the roots of Vladimiria souliei. Their chemical structures were determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR spectroscopic data. Their absolute configurations were established by Mosher's method and ECD experiments. Furthermore, biological studies showed that compound 1 showed prominent neuroprotective effects against glutamate-induced neurotoxicity in PC-12 cells, with EC50 values of 13.54 ± 0.33 µM, while, the EC50 value of compound 2 is greater than 30 µM.
RESUMO
A new bilobalide isomer (1), together with two flavonol glycosides (2, 3), have been isolated and elucidated from the extract of Ginkgo biloba leaves. Significantly, 1 was a new sesquiterpene lactone with two lactone ring groups, both 2 and 3 were two flavonol glycosides with a same cis-coumaroylated fragment. Their chemical structures were elucidated by NMR and MS spectroscopic date and the absolute configuration of 1 was specific established by Cu-Kα X-ray crystallographic analyses. However, 1-3 showed no obvious anti-platelet aggregation activity.
Assuntos
Bilobalídeos/isolamento & purificação , Flavonóis/isolamento & purificação , Ginkgo biloba/química , Glicosídeos/isolamento & purificação , Bilobalídeos/química , Ciclopentanos/química , Ciclopentanos/isolamento & purificação , Flavonóis/química , Furanos/química , Furanos/isolamento & purificação , Ginkgolídeos/química , Ginkgolídeos/isolamento & purificação , Glicosídeos/química , Folhas de Planta/químicaRESUMO
Three rare squiterpene lactone dimers lineariifolianoids M-O (1-3) were isolated from Inula lineariifolia for the first time. Their structures and absolute configuration were established on the basis of by NMR and MS spectroscopic data and X-ray crystallography. Furthermore, those three compounds exhibited significant inhibitory activity against LPS-induced NO production in RAW 264.7 macrophages with IC50 values of 1.421, 1.087 and 1.243 µM, respectively.