Prognostic model based on image-based time-frequency features and genetic algorithm for fetal hypoxia assessment.

Cardiotocography (CTG) is applied routinely for fetal monitoring during the perinatal period to decrease the rates of neonatal mortality and morbidity as well as unnecessary interventions. The analysis of CTG traces has become an indispensable part of present clinical practices; however, it also has serious drawbacks, such as poor specificity and variability in its interpretation. The automated CTG analysis is seen as the most promising way to overcome these disadvantages. In this study, a novel prognostic model is proposed for predicting fetal hypoxia from CTG traces based on an innovative approach called image-based time-frequency (IBTF) analysis comprised of a combination of short time Fourier transform (STFT) and gray level co-occurrence matrix (GLCM). More specifically, from a graphical representation of the fetal heart rate (FHR) signal, the spectrogram is obtained by using STFT. The spectrogram images are converted into 8-bit grayscale images, and IBTF features such as contrast, correlation, energy, and homogeneity are utilized for identifying FHR signals. At the final stage of the analysis, different subsets of the feature space are applied as the input to the least square support vector machine (LS-SVM) classifier to determine the most informative subset. For this particular purpose, the genetic algorithm is employed. The prognostic model was performed on the open-access intrapartum CTU-UHB CTG database. The sensitivity and specificity obtained using only conventional features were 57.33% and 67.24%, respectively, whereas the most effective results were achieved using a combination of conventional and IBTF features, with a sensitivity of 63.45% and a specificity of 65.88%. Conclusively, this study provides a new promising approach for feature extraction of FHR signals. In addition, the experimental outcomes showed that IBTF features provided an increase in the classification accuracy.

Variable selection in Logistic regression model with genetic algorithm.

Variable or feature selection is one of the most important steps in model specification. Especially in the case of medical-decision making, the direct use of a medical database, without a previous analysis and preprocessing step, is often counterproductive. In this way, the variable selection represents the method of choosing the most relevant attributes from the database in order to build a robust learning models and, thus, to improve the performance of the models used in the decision process. In biomedical research, the purpose of variable selection is to select clinically important and statistically significant variables, while excluding unrelated or noise variables. A variety of methods exist for variable selection, but none of them is without limitations. For example, the stepwise approach, which is highly used, adds the best variable in each cycle generally producing an acceptable set of variables. Nevertheless, it is limited by the fact that it commonly trapped in local optima. The best subset approach can systematically search the entire covariate pattern space, but the solution pool can be extremely large with tens to hundreds of variables, which is the case in nowadays clinical data. Genetic algorithms (GA) are heuristic optimization approaches and can be used for variable selection in multivariable regression models. This tutorial paper aims to provide a step-by-step approach to the use of GA in variable selection. The R code provided in the text can be extended and adapted to other data analysis needs.