Doping Engineering of Conductive Polymers and Their Application in Physical Sensors for Healthcare Monitoring.

Physical sensors have emerged as a promising technology for real-time healthcare monitoring, which tracks various physical signals from the human body. Accurate acquisition of these physical signals from biological tissue requires excellent electrical conductivity and long-term durability of the sensors under complex mechanical deformation. Conductive polymers, combining the advantages of conventional polymers and organic conductors, are considered ideal conductive materials for healthcare physical sensors due to their intrinsic conductive network, tunable mechanical properties, and easy processing. Doping engineering has been proposed as an effective approach to enhance the sensitivity, lower the detection limit, and widen the operational range of sensors based on conductive polymers. This approach enables the introduction of dopants into conductive polymers to adjust and control the microstructure and energy levels of conductive polymers, thereby optimizing their mechanical and conductivity properties. This review article provides a comprehensive overview of doping engineering methods to improve the physical properties of conductive polymers and highlights their applications in the field of healthcare physical sensors, including temperature sensors, strain sensors, stress sensors, and electrophysiological sensing. Additionally, the challenges and opportunities associated with conductive polymer-based physical sensors in healthcare monitoring are discussed.

Hydrogel-Based Bioelectronics and Their Applications in Health Monitoring.

Flexible bioelectronics exhibit promising potential for health monitoring, owing to their soft and stretchable nature. However, the simultaneous improvement of mechanical properties, biocompatibility, and signal-to-noise ratio of these devices for health monitoring poses a significant challenge. Hydrogels, with their loose three-dimensional network structure that encapsulates massive amounts of water, are a potential solution. Through the incorporation of polymers or conductive fillers into the hydrogel and special preparation methods, hydrogels can achieve a unification of excellent properties such as mechanical properties, self-healing, adhesion, and biocompatibility, making them a hot material for health monitoring bioelectronics. Currently, hydrogel-based bioelectronics can be used to fabricate flexible bioelectronics for motion, bioelectric, and biomolecular acquisition for human health monitoring and further clinical applications. This review focuses on materials, devices, and applications for hydrogel-based bioelectronics. The main material properties and research advances of hydrogels for health monitoring bioelectronics are summarized firstly. Then, we provide a focused discussion on hydrogel-based bioelectronics for health monitoring, which are classified as skin-attachable, implantable, or semi-implantable depending on the depth of penetration and the location of the device. Finally, future challenges and opportunities of hydrogel-based bioelectronics for health monitoring are envisioned.

Biomimetic Flexible Sensors and Their Applications in Human Health Detection.

Bionic flexible sensors are a new type of biosensor with high sensitivity, selectivity, stability, and reliability to achieve detection in complex natural and physiological environments. They provide efficient, energy-saving and convenient applications in medical monitoring and diagnosis, environmental monitoring, and detection and identification. Combining sensor devices with flexible substrates to imitate flexible structures in living organisms, thus enabling the detection of various physiological signals, has become a hot topic of interest. In the field of human health detection, the application of bionic flexible sensors is flourishing and will evolve into patient-centric diagnosis and treatment in the future of healthcare. In this review, we provide an up-to-date overview of bionic flexible devices for human health detection applications and a comprehensive summary of the research progress and potential of flexible sensors. First, we evaluate the working mechanisms of different classes of bionic flexible sensors, describing the selection and fabrication of bionic flexible materials and their excellent electrochemical properties; then, we introduce some interesting applications for monitoring physical, electrophysiological, chemical, and biological signals according to more segmented health fields (e.g., medical diagnosis, rehabilitation assistance, and sports monitoring). We conclude with a summary of the advantages of current results and the challenges and possible future developments.

A Flexible Piezocapacitive Pressure Sensor with Microsphere-Array Electrodes.

Flexible pressure sensors that emulate the sensation and characteristics of natural skins are of great importance in wearable medical devices, intelligent robots, and human-machine interfaces. The microstructure of the pressure-sensitive layer plays a significant role in the sensor's overall performance. However, microstructures usually require complex and costly processes such as photolithography or chemical etching for fabrication. This paper proposes a novel approach that combines self-assembled technology to prepare a high-performance flexible capacitive pressure sensor with a microsphere-array gold electrode and a nanofiber nonwoven dielectric material. When subjected to pressure, the microsphere structures of the gold electrode deform via compressing the medium layer, leading to a significant increase in the relative area between the electrodes and a corresponding change in the thickness of the medium layer, as simulated in COMSOL simulations and experiments, which presents high sensitivity (1.807 kPa-1). The developed sensor demonstrates excellent performance in detecting signals such as slight object deformations and human finger bending.

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review.

Microfluidics has recently received more and more attention in applications such as biomedical, chemical and medicine. With the development of microelectronics technology as well as material science in recent years, microfluidic devices have made great progress. Porous structures as a discontinuous medium in which the special flow phenomena of fluids lead to their potential and special applications in microfluidics offer a unique way to develop completely new microfluidic chips. In this article, we firstly introduce the fabrication methods for porous structures of different materials. Then, the physical effects of microfluid flow in porous media and their related physical models are discussed. Finally, the state-of-the-art porous microfluidic chips and their applications in biomedicine are summarized, and we present the current problems and future directions in this field.

A Wide-Range-Response Piezoresistive-Capacitive Dual-Sensing Breathable Sensor with Spherical-Shell Network of MWCNTs for Motion Detection and Language Assistance.

It is still a challenge for flexible electronic materials to realize integrated strain sensors with a large linear working range, high sensitivity, good response durability, good skin affinity and good air permeability. In this paper, we present a simple and scalable porous piezoresistive/capacitive dual-mode sensor with a porous structure in polydimethylsiloxane (PDMS) and with multi-walled carbon nanotubes (MWCNTs) embedded on its internal surface to form a three-dimensional spherical-shell-structured conductive network. Thanks to the unique spherical-shell conductive network of MWCNTs and the uniform elastic deformation of the cross-linked PDMS porous structure under compression, our sensor offers a dual piezoresistive/capacitive strain-sensing capability, a wide pressure response range (1-520 kPa), a very large linear response region (95%), excellent response stability and durability (98% of initial performance after 1000 compression cycles). Multi-walled carbon nanotubes were coated on the surface of refined sugar particles by continuous agitation. Ultrasonic PDMS solidified with crystals was attached to the multi-walled carbon nanotubes. After the crystals were dissolved, the multi-walled carbon nanotubes were attached to the porous surface of the PDMS, forming a three-dimensional spherical-shell-structure network. The porosity of the porous PDMS was 53.9%. The large linear induction range was mainly related to the good conductive network of the MWCNTs in the porous structure of the crosslinked PDMS and the elasticity of the material, which ensured the uniform deformation of the porous structure under compression. The porous conductive polymer flexible sensor prepared by us can be assembled into a wearable sensor with good human motion detection ability. For example, human movement can be detected by responding to stress in the joints of the fingers, elbows, knees, plantar, etc., during movement. Finally, our sensors can also be used for simple gesture and sign language recognition, as well as speech recognition by monitoring facial muscle activity. This can play a role in improving communication and the transfer of information between people, especially in facilitating the lives of people with disabilities.

Wearable Near-Field Communication Sensors for Healthcare: Materials, Fabrication and Application.

The wearable device industry is on the rise, with technology applications ranging from wireless communication technologies to the Internet of Things. However, most of the wearable sensors currently on the market are expensive, rigid and bulky, leading to poor data accuracy and uncomfortable wearing experiences. Near-field communication sensors are low-cost, easy-to-manufacture wireless communication technologies that are widely used in many fields, especially in the field of wearable electronic devices. The integration of wireless communication devices and sensors exhibits tremendous potential for these wearable applications by endowing sensors with new features of wireless signal transferring and conferring radio frequency identification or near-field communication devices with a sensing function. Likewise, the development of new materials and intensive research promotes the next generation of ultra-light and soft wearable devices for healthcare. This review begins with an introduction to the different components of near-field communication, with particular emphasis on the antenna design part of near-field communication. We summarize recent advances in different wearable areas of near-field communication sensors, including structural design, material selection, and the state of the art of scenario-based development. The challenges and opportunities relating to wearable near-field communication sensors for healthcare are also discussed.

Ultrathin and Conformable Lead Halide Perovskite Photodetector Arrays for Potential Application in Retina-Like Vision Sensing.

Solution-processed lead halide perovskites are considered one of the promising materials for flexible optoelectronics. However, the array integration of ultrathin flexible perovskite photodetectors (PDs) remains a significant challenge limited by the incompatibility of perovskite materials with manufacturing techniques involving polar liquids. Here, an ultrathin (2.4 µm) and conformable perovskite-based PD array (10 × 10 pixels) with ultralight weight (3.12 g m-2 ) and excellent flexibility, is reported. Patterned all-inorganic CsPbBr3 perovskite films with precise pixel position, controllable morphology, and homogenous dimension, are synthesized by a vacuum-assisted drop-casting patterning process as the active layer. The use of waterproof parylene-C film as substrate and encapsulation layer effectively protects the perovskite films against penetration of polar liquids during the peeling-off process. Benefitting from the encapsulation and ultrathin property, the device exhibits long-term stability in the ambient environment, and robust mechanical stability under bending or 50% compressive strain. More importantly, the ultrathin flexible PD arrays conforming to hemispherical support realize imaging of light distribution, indicating the potential applications in retina-like vision sensing.

Voltage-Driven Room-Temperature Resistance and Magnetization Switching in Ceramic TiO2/PAA Nanoporous Composite Films.

Voltage control of room-temperature ferromagnetism has remained a big challenge which will greatly influence the multifunctional memory devices. In this paper, porous TiO2 thin films were deposited by dc-reactive magnetron sputtering onto ordered porous anodic alumina (PAA) substrates. Voltage-driving room-temperature resistance and magnetization switching without external magnetic field are simultaneously found in an Ag/TiO2/PAA/Al (Ag/TP/Al) device. Further analysis indicates that the formation/rupture of oxygen vacancy defect-based conductive filaments would be responsible for the changes of resistivity and magnetization. Our present results suggest that the TP nanoporous composite film material may therefore be used to achieve voltage control of magnetism and resistance switching in the future multifunctional memory devices. The Ag/TP/Al devices can also be used for new spintronic devices, neuromorphic operations, and alternative logic circuits and computing.