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1.
PeerJ Comput Sci ; 10: e2161, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38983226

RESUMO

In the dynamic field of deep reinforcement learning, the self-attention mechanism has been increasingly recognized. Nevertheless, its application in discrete problem domains has been relatively limited, presenting complex optimization challenges. This article introduces a pioneering deep reinforcement learning algorithm, termed Attention-based Actor-Critic with Priority Experience Replay (A2CPER). A2CPER combines the strengths of self-attention mechanisms with the Actor-Critic framework and prioritized experience replay to enhance policy formulation for discrete problems. The algorithm's architecture features dual networks within the Actor-Critic model-the Actor formulates action policies and the Critic evaluates state values to judge the quality of policies. The incorporation of target networks aids in stabilizing network optimization. Moreover, the addition of self-attention mechanisms bolsters the policy network's capability to focus on critical information, while priority experience replay promotes training stability and reduces correlation among training samples. Empirical experiments on discrete action problems validate A2CPER's adeptness at policy optimization, marking significant performance improvements across tasks. In summary, A2CPER highlights the viability of self-attention mechanisms in reinforcement learning, presenting a robust framework for discrete problem-solving and potential applicability in complex decision-making scenarios.

2.
PeerJ ; 7: e7909, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31637139

RESUMO

Metabolic syndrome is a cluster of the most dangerous heart attack risk factors (diabetes and raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure), and has become a major global threat to human health. A number of studies have demonstrated that hundreds of non-coding RNAs, including miRNAs and lncRNAs, are involved in metabolic syndrome-related diseases such as obesity, type 2 diabetes mellitus, hypertension, etc. However, these research results are distributed in a large number of literature, which is not conducive to analysis and use. There is an urgent need to integrate these relationship data between metabolic syndrome and non-coding RNA into a specialized database. To address this need, we developed a metabolic syndrome-associated non-coding RNA database (ncRNA2MetS) to curate the associations between metabolic syndrome and non-coding RNA. Currently, ncRNA2MetS contains 1,068 associations between five metabolic syndrome traits and 627 non-coding RNAs (543 miRNAs and 84 lncRNAs) in four species. Each record in ncRNA2MetS database represents a pair of disease-miRNA (lncRNA) association consisting of non-coding RNA category, miRNA (lncRNA) name, name of metabolic syndrome trait, expressive patterns of non-coding RNA, method for validation, specie involved, a brief introduction to the association, the article referenced, etc. We also developed a user-friendly website so that users can easily access and download all data. In short, ncRNA2MetS is a complete and high-quality data resource for exploring the role of non-coding RNA in the pathogenesis of metabolic syndrome and seeking new treatment options. The website is freely available at http://www.biomed-bigdata.com:50020/index.html.

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