RESUMO
Simultaneously achieving a high photoluminescence quantum yield (PLQY), ultrashort exciton lifetime, and suppressed concentration quenching in thermally activated delayed fluorescence (TADF) materials is desirable yet challenging. Here, a novel acceptor-donor-acceptor type TADF emitter, namely, 2BO-sQA, wherein two oxygen-bridged triarylboron (BO) acceptors are arranged with cofacial alignment and positioned nearly orthogonal to the rigid dispirofluorene-quinolinoacridine (sQA) donor is reported. This molecular design enables the compound to achieve highly efficient (PLQYs up to 99%) and short-lived (nanosecond-scale) blue TADF with effectively suppressed concentration quenching in films. Consequently, the doped organic light-emitting diodes (OLEDs) base on 2BO-sQA achieve exceptional electroluminescence performance across a broad range of doping concentrations, maintaining maximum external quantum efficiencies (EQEs) at over 30% for doping concentrations ranging from 10 to 70 wt%. Remarkably, the nondoped blue OLED achieves a record-high maximum EQE of 26.6% with a small efficiency roll-off of 14.0% at 1000 candelas per square meter. By using 2BO-sQA as the sensitizer for the multiresonance TADF emitter ν-DABNA, TADF-sensitized fluorescence OLEDs achieve high-efficiency deep-blue emission. These results demonstrate the feasibility of this molecular design in developing TADF emitters with high efficiency, ultrashort exciton lifetime, and minimal concentration quenching.
RESUMO
Background: Osteosarcoma (OS) is the most prevalent malignant primary bone tumor in children. Selectin P ligand gene (SELPLG) has been studied in several cancers. Our research aimed to explore the role of SELPLG in OS. Methods: All OS patient data was obtained from TARGET and GEO databases. Differential expression analyses were conducted in limma package of R. Functional analyses included GO and KEGG enrichment analyses. Immune cell infiltration analysis was done in CIBERSORT software. The overall survival was calculated using survival and survminer package of R. Results: Significantly lower SELPLG expression was observed in metastatic OS samples compared with non-metastatic OS samples, both in TARGET and in GSE21257. Low SELPLG expression was an independent undesirable prognostic factor for OS patients, in both TARGET and GEO datasets. Totally 62 differentially expressed gene (DEG) overlaps were found between high SELPLG vs. low SELPLG and non-metastatic vs. metastatic OS samples, affecting metastases and thereby influencing the prognosis, which were significantly enriched in 40 GO and six KEGG terms. Five types of immune cells were significantly differentially infiltrated between high and low SELPLG expression OS patients. Conclusion: SELPLG is closely correlated with metastases and prognosis of OS patients. The OS patients with low SELPLG expression have relatively poorer prognosis and SELPLG is a potential prognostic biomarker for OS.
Assuntos
Biomarcadores Tumorais/metabolismo , Neoplasias Ósseas/patologia , Glicoproteínas de Membrana/biossíntese , Osteossarcoma/patologia , Humanos , Glicoproteínas de Membrana/análise , PrognósticoRESUMO
INTRODUCTION: We report an unusual case compression of the palmar cutaneous branch of the median nerve(PCBNN). PRESENTATION OF CASE: A 52-year-old woman presenting with previous rupture of the palmaris longus tendon. During surgery, we found that the end of the tendon had formed nodules. After removing the nodules, the PCBMN was released, and half a year later, the abnormal feelings had disappeared. DISCUSSION: We aim to remind surgeons of this type of compression and to highlight the importance of maintaining vigilance in order to avoid nerve injury. CONCLUSION: PCBMN needs to be paid more attention and damaged tendons should be repaired.
Assuntos
Neoplasias Ósseas/patologia , Proliferação de Células/efeitos dos fármacos , Clonidina/análogos & derivados , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Osteossarcoma/patologia , Fosfatidilinositol 3-Quinases/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Anticonvulsivantes/farmacologia , Neoplasias Ósseas/tratamento farmacológico , Neoplasias Ósseas/metabolismo , Movimento Celular , Clonidina/farmacologia , Humanos , Osteossarcoma/tratamento farmacológico , Osteossarcoma/metabolismo , Fosfatidilinositol 3-Quinases/genética , Proteínas Proto-Oncogênicas c-akt/genética , Transdução de Sinais , Células Tumorais CultivadasRESUMO
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. The authors purportedly reviewed seven randomised trials. However, on reviewing the included studies, it became clear that most (if not all, as some were not able to be retrieved or translated) were not randomised trials. The authors included observational studies as randomised trials and also included information (apparently extracted independently by two authors) that did not exist (e.g., the method of randomisation and the presence of allocation concealment) or was clearly false (e.g., assessor blinding). The Publisher would like to apologise to any readers who were misled by information contained in this article.
Assuntos
Fixação Interna de Fraturas , Consolidação da Fratura/fisiologia , Redução Aberta , Complicações Pós-Operatórias/cirurgia , Fraturas da Tíbia/cirurgia , Humanos , Duração da Cirurgia , Ensaios Clínicos Controlados Aleatórios como Assunto , Fraturas da Tíbia/fisiopatologia , Resultado do TratamentoRESUMO
In this study, the performances of different preparation methods of the scaffolds were analyzed for chondrocyte tissue engineering. Silk fibroin/collagen (SF/C) was fabricated using a vacuum freeze-dried technique and by 3D printing. The porosity, water absorption expansion rates, mechanical properties, and pore sizes of the resulting materials were evaluated. The proliferation and metabolism of the cells was detected at different time points using an MTT assay. Cell morphologies and distributions were observed by histological analysis and scanning electron microscopy (SEM). The porosity, water absorption expansion rate, and Young's modulus of the material obtained via 3D printing were significantly higher than those obtained by the freeze-dried method, while the pore size did not differ significantly between the two methods. MTT assay results showed that the metabolism of cells seeded on the 3D printed scaffolds was more viable than the metabolism on the freeze-dried material. H&E staining of the scaffolds revealed that the number of cells in the 3D printed scaffold was higher in comparison to a similar measurement on the freeze-dried material. Consequently, stem cells grew well inside the 3D printed scaffolds, as measured by SEM, while the internal structure of the freeze-dried scaffold was disordered. Compared with the freeze-dried technique, the 3D printed scaffold exhibited better overall performance and was more suitable for cartilage tissue engineering.
Assuntos
Colágeno/química , Fibroínas/química , Liofilização/métodos , Células-Tronco Mesenquimais/fisiologia , Impressão Tridimensional , Alicerces Teciduais , Animais , Materiais Biomiméticos/síntese química , Proliferação de Células/fisiologia , Sobrevivência Celular/fisiologia , Células Cultivadas , Força Compressiva , Desenho de Equipamento , Análise de Falha de Equipamento , Matriz Extracelular/química , Teste de Materiais , Células-Tronco Mesenquimais/citologia , Porosidade , Ratos , Ratos Wistar , Engenharia Tecidual/métodos , VácuoRESUMO
A novel copolymer has been synthesized by the radical polymerization of poly (ethylene oxide) methacrylate, stearyl methacrylate, hydroxypropyl methacrylate and trimethoxysilylpropyl methacrylate. The polymer was characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance (1H-NMR) spectroscopy and gel permeation chromatography. The crosslinkable coating was prepared by dip-coating 5mg/ml solution in tetrahydrofuran onto glass substrate. A stable crosslinked coating was obtained after curing the coating at 70 degrees C for 9 h. Contact angle results indicated the possible reorganization of the surface amphiphilic molecule which interpreted the excellent biocompatibility revealed by the results of the platelet adhesion and plasma recalcification time. Rhodamine S and Cibacron Blue were used as model drugs to prepare drug-containing coating at the same conditions. Drug-releasing curves indicated that the mechanism of the release is approximately Fickian release.