[The molecular aspects of the functional heterogeneity of the GABA receptors]. / Molekuliarnye aspekty funktsional'noi geterogennosti GAMK-retseptorov.

It is generally accepted that gamma-aminobutyric acid (GABA) is one of the main inhibitory transmitter in the mammalian brain. There are three types of GABA receptors in the vertebrata central nervous system: the GABAA, GABAB and GABAC receptors. The GABAA receptor is a GABA-gated Cl- channel and is the tetramer ore the pentamer made of some classes of subunit (alpha, beta, gamma, delta). GABAB receptors are not affiliated with Cl(-) ionophore. GABAB receptors appear to be coupled to Ca2+ and K+ channels of presynaptic membranes. It seems they regulate the release of neurotransmitters release. The structural and functional properties of GABA receptors are discussed.

[The effect of perftoran on the resistance of mice to GABA receptor antagonists and on the antidote activity of anticonvulsant agents]. / Vliianie perftorana na ustoichivost' myshei k antagonistam GAMK-retseptorov i antidotnuiu aktivnost' protivosudorozhnykh sredstv.

Perfluorane (a phenobarbital-type inducer of the microsomal enzyme system) raised the resistance of mice to the toxic effect of picrotoxin and bicucullin in 7 days after injection. The antidote effect of diazepam and phenobarbital increased under such conditions. In experiments in vitro a modulatory effect of perftorane on the central muscarine and benzodiazepine receptors was demonstrated.