RESUMO
High incidence of cobalt deficiency (89%) was found in 7-8-year-old girls residents of the Republic of Tatarstan. Significant correlations were revealed between parameters of physical development and cardiovascular system and hair cobalt content. These data suggest that positive balance of cobalt is essential for normal growth and development of child's body and function of the cardiovascular system.
Assuntos
Sistema Cardiovascular/metabolismo , Desenvolvimento Infantil/fisiologia , Cobalto/deficiência , Cobalto/metabolismo , Deficiências Nutricionais/epidemiologia , Circulação Sanguínea , Índice de Massa Corporal , Criança , Cobalto/análise , Feminino , Cabelo/química , Hemodinâmica/fisiologia , Humanos , Incidência , Espectrometria de Massas , Pletismografia de Impedância , Pulso Arterial , Federação Russa/epidemiologia , Espectrofotometria AtômicaRESUMO
The content of essential and toxic elements, except beryllium and mercury, in the hair of examined children (girls aged 7-9 years) is within the biologically acceptable levels set by WHO. The data on the content of essential trace elements suggest that urgent measures aimed at normalization of the elemental status of children are required.
Assuntos
Cabelo/química , Oligoelementos/química , Criança , Exposição Ambiental , Feminino , Humanos , População Rural , Federação Russa , Poluentes do Solo/química , Poluentes do Solo/metabolismo , Oligoelementos/metabolismo , Poluentes da Água/química , Poluentes da Água/metabolismoRESUMO
Changes in cardiac rhythm induced by blockade of hyperpolarization currents with ZD 7288 depend on animal's age. The increase in cardiointerval duration is related to prolongation of T-P segment on ECG. It is hypothesized that the age-related changes in activity of hyperpolarization channels are determined by a modulating effect of the autonomic nervous system.
Assuntos
Envelhecimento/fisiologia , Frequência Cardíaca/fisiologia , Animais , Cardiotônicos/farmacologia , Frequência Cardíaca/efeitos dos fármacos , Canais Iônicos/fisiologia , Pirimidinas/farmacologia , RatosRESUMO
Intravenous injection of ZD 7288, a new specific hyperpolarizing current blocker, dose-dependently reduces heart rate in adult rats. The autonomic nervous system modulates changes in heart rate caused by hyperpolarizing currents.
Assuntos
Fármacos Cardiovasculares/farmacologia , Frequência Cardíaca/efeitos dos fármacos , Potenciais da Membrana/efeitos dos fármacos , Pirimidinas/farmacologia , Animais , Fármacos Cardiovasculares/administração & dosagem , Relação Dose-Resposta a Droga , Eletrocardiografia , Frequência Cardíaca/fisiologia , Injeções Intravenosas , Pirimidinas/administração & dosagem , RatosRESUMO
Prepubertal period in rats is characterized by some peculiarities of the cardiac regulatory mechanisms. In 6-week-old rats atropine produced bradycardia instead of tachycardia. Similar reaction was not observed in chemically sympathectomized age-matched rats.
