[Laws and regulations affecting the development of national service of clinical toxicology].

In the formation and development of the national specialized toxicological service the important role was played by legislative initiatives, distinguished with continuity and improvement of the quality of care in acute poisoning, principles of interaction of units of service. Since the beginning of the organization of specialized toxicological service in the country, without taking into account the regional regulations, there were published over thirty ones, impact and significance of which can be very positively evaluated by formed a unique and authoritative national school of clinical toxicology, with its wealth of organizational, methodological and diagnostic and treatment practices, valuable scientific and human resources.

[Comparative effectiveness of different methods of diagnosis and correction of impaired portal circulation]. / Sravnitel'naia éffektivnost' razlichnykh metodov diagnostiki i korrektsii narushenii portal'nogo krovoobrashcheniia.

The diagnostic effectiveness of X-ray radionuclide and ultrasound determination of portal blood flow and the impact of different treatments on the blood flow were evaluated in 76 patients with hepatic cirrhosis. The treatment regimens were used propranolol (Group 1), isosorbide-5-mononitrate (monosan) (Group 2), and a combined therapy with propranolol in combination with diuretics and a course of intravenous laser irradiation (Group 3). In terms of both clinical and laboratory parameters and the status of portal circulation, the highest effect was observed in the patients receiving the combined therapy.

[The role of hyperlipoperoxidation in the development of chronic acalculous and calculous cholecystitis]. / Znachenie giperlipoperoksidatsii v razvitii khronicheskogo beskamennogo i kal'kuleznogo kholetsistita.

Upon studying the factors contributory to development of acalculous and calculous cholecystitis it was found that bioelement composition and physicochemical properties of the bile undergo marked changes. These become more pronounced in hyperproduction of secondarylipid peroxides. Being responsible for conformation changes of biliary macromolecular structures and for cytolysis of cellular elements, hyperlipoperoxidation can determine the signs of their antigenic specificity as well as the onset of hypercholesterol- andhigh bile level of bilirubin as confirmed in guinea pig experiments. Hyperlipoperoxidation proved a powerful colloid-destabilizing factor of the bile able to trigger lithogenesis.

[Incidence of cholelithiasis after its experimental induction by various methods]. / Chastota kholelitiaza pri razlichnykh sposobakh ego induktsii v éksperimente.

The incidence rate of cholelithiasis was studied in varying methods of lithogenic stimulation: a diet enriched with cholesterol and chenodesoxycholic acid, induction of acute aseptic inflammation of the gallbladder by thermal damage, and the use of ++anti-gallbladder sera. The results of the study have shown almost similar (44-52%) reproducibility of cholelithiasis in guinea pigs, the development of pigment concrements was recorded in the absolute majority of cases. Correlation of the cholelithiasis incidence rate with inflammatory disorders in the gallbladder has evidenced the importance of the immunoallergic component in the determination of acute cholelithiasis and cholelithiasis, where cholelithiasis shows its secondary character.