New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis.

Anti-tumor necrosis factor (anti-TNF) drugs are effective against psoriasis, although 20-30% of patients are nonresponders. Few pharmacogenomic studies have been performed to predict the response to anti-TNF drugs in psoriasis. We studied 173 polymorphisms to establish an association with the response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis (N=144). We evaluated the response using PASI75 at 3, 6 and 12 months. The results of the multivariate analysis showed an association between polymorphisms in PGLYR4, ZNF816A, CTNNA2, IL12B, MAP3K1 and HLA-C genes and the response at 3 months. Besides, the results for polymorphisms in IL12B and MAP3K1 were replicated at 6 months. We also obtained significant results for IL12B polymorphism at 1 year. Moreover, polymorphisms in FCGR2A, HTR2A and CDKAL1 were significant at 6 months. This is the first study to show an association with these polymorphisms. However, these biomarkers should be validated in large-scale studies before implementation in clinical practice.

Patients treated with obstructive sleep apnea syndrome and fitness to drive assessment in clinical practice in Spain at the medical traffic centers.

OBJECTIVE: To assess fitness to drive among drivers with treated obstructive sleep apnea syndrome. METHODS: A total of 5234 drivers who attended two Spanish Medical Driver Test Centers for assessment of their fitness to drive prior to renewing or issuing their driving license were included in the study. Information regarding sociodemographic aspects, patterns of driving, medical condition, medication use, and patterns of alcohol consumption was recorded. RESULTS: Eleven out of 5234 drivers (0.2%) suffered from obstructive sleep apnea syndrome, all of them being treated with continuous positive airway pressure, and they were found fit to drive with restrictions. CONCLUSIONS: A lower than expected prevalence of patients with obstructive sleep apnea syndrome was found among drivers undergoing fitness to drive assessment. Suffering from obstructive sleep apnea syndrome does not prevent driving as long as the patient is undergoing adequately controlled treatment.

[Fitness-to-drive assessment in drivers with neurological and neuromuscular disorders at the driving test centres]. / Evaluación en los centros de reconocimiento de conductores de los pacientes con patología neurológica y neuromuscular.

INTRODUCTION: Drivers with a neurological pathology have a greater risk of involvement in traffic accidents than healthy drivers. AIM: To evaluate the fitness to drive of drivers with a neurological or neuromuscular pathology. SUBJECTS AND METHODS: 5,234 drivers attending two Medical Driver Test Centres with the aim of carrying out a medical-psychological examination to obtain or renew their driving license were included in the study. Information was obtained concerning sociodemographic aspects, driving habits, the referred pathology and consumption of medicaments and alcohol. RESULTS: 1.4% of the drivers presented a neuromuscular or neurological pathology. The most frequent were muscular disorders of a neurological origin (32.5%), a history of cerebrovascular accidents (27%) and epilepsy (24.3%). 21.6% of the drivers were considered 'fit', 77.1% were 'fit with restrictions', and only 1.3% were considered 'unfit' to drive. CONCLUSIONS: The great majority of drivers (98.7%) with a neurological pathology are considered 'fit' or 'fit with restrictions' to drive. Even though only a small percentage of divers with neurological pathologies are considered 'unfit' to drive, given their increased risk of involvement in traffic accidents, an early, individual evaluation of these patients' fitness to drive, taking into account the associated pathology, prescribed medication, consumption of alcohol and age, would seem necessary.

Demand for prior treatment in alcoholic patients.

The aim of this study is to analyze the use of health care resources by alcoholic patients. A prospective study of 176 patients (147 males, 29 females; mean age 42.9 years) diagnosed as alcohol dependent, according to criteria DSM-IV, has been carried out over one year (June 2002 to June 2003) in three centers of treatment for alcoholics in Castilla y León (Spain). Of the 176 patients, 67% had previously requested treatment for their alcoholism in other centers, mainly in mental-health (37.5%), emergency (34.1%), and primary care (31.8%). On average, they had requested treatment 2.27 times, the women more frequently than the men. The current study shows that alcohol-dependent patients frequently use health care services during the history of their dependence to treat their illness.

Road traffic accidents among alcohol-dependent patients: the effect of treatment.

It is well known that driving under the influence of alcohol increases the risk of traffic accidents. Alcohol-dependent patients are responsible for two-thirds of motor vehicle crashes involving alcohol. Studies carried out on the general population have shown a relation between alcohol dependence and traffic accidents. The aim of the study is to analyse the effect on traffic accidents of treatment of patients with alcohol-related problems. To do so, the prevalence of traffic problems in a sample of patients with a diagnosed dependence on alcohol was assessed for three periods: during their lifetime, in the year preceding the start of treatment and over the year of treatment. A prospective study was carried out of 176 patients (147 males, 29 females; mean age 42.9 years) diagnosed as alcohol dependent according to the DSM-IV criteria in three alcoholic treatment centres in Castilla y León, Spain. 36.9% of the alcohol-dependent patients had had some kind of traffic problem during their life and 8.5% in the year prior to starting treatment. The most frequent problem was positive breath tests, followed by accidents with damage to the vehicle. Sixty-nine of the 176 patients were still receiving treatment after a year. The prevalence of traffic problems among those patients who followed treatment for 1 year (4.3%) was lower than in the year before treatment (15.9%). The study showed that the treatment is also effective in reducing traffic problems.