Assuntos
COVID-19/imunologia , Células Matadoras Naturais/imunologia , Subpopulações de Linfócitos/imunologia , Antígenos CD19/imunologia , Povo Asiático , Linfócitos B/imunologia , Contagem de Células Sanguíneas , Complexo CD3/imunologia , Linfócitos T CD4-Positivos/imunologia , Antígeno CD56/imunologia , Linfócitos T CD8-Positivos/imunologia , COVID-19/epidemiologia , COVID-19/fisiopatologia , Feminino , Citometria de Fluxo , Corantes Fluorescentes/química , Proteínas Ligadas por GPI/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Receptores de IgG/imunologiaRESUMO
We established a normal reference range for peripheral blood lymphocyte subsets in a multiracial adult population by using single-platform flow cytometry. Further analysis of our cohort showed that the CD8+-cell counts decrease with age, there is a gender difference in NK cell percentages and counts, and there are significant differences in the CD3+-, CD4+-, and CD19+-cell counts between Indians and other racial groups. Overall, our results are significantly different from other published data. This difference further stresses the need for different populations to establish their own reference ranges as these may have important implications for the management of patients with human immunodeficiency virus and AIDS. The use of single-platform flow cytometry will eliminate some of the variability between different study centers, making studies more comparable. This platform should be used for future studies into the effects of age, sex, and race on lymphocyte subsets.