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ACS Nano ; 18(19): 12453-12467, 2024 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-38686995

RESUMO

Traditional magnetic resonance imaging (MRI) contrast agents (CAs) are a type of "always on" system that accelerates proton relaxation regardless of their enrichment region. This "always on" feature leads to a decrease in signal differences between lesions and normal tissues, hampering their applications in accurate and early diagnosis. Herein, we report a strategy to fabricate glutathione (GSH)-responsive one-dimensional (1-D) manganese oxide nanoparticles (MONPs) with improved T2 relaxivities and achieve effective T2/T1 switchable MRI imaging of tumors. Compared to traditional contrast agents with high saturation magnetization to enhance T2 relaxivities, 1-D MONPs with weak Ms effectively increase the inhomogeneity of the local magnetic field and exhibit obvious T2 contrast. The inhomogeneity of the local magnetic field of 1-D MONPs is highly dependent on their number of primary particles and surface roughness according to Landau-Lifshitz-Gilbert simulations and thus eventually determines their T2 relaxivities. Furthermore, the GSH responsiveness ensures 1-D MONPs with sensitive switching from the T2 to T1 mode in vitro and subcutaneous tumors to clearly delineate the boundary of glioma and metastasis margins, achieving precise histopathological-level MRI. This study provides a strategy to improve T2 relaxivity of magnetic nanoparticles and construct switchable MRI CAs, offering high tumor-to-normal tissue contrast signal for early and accurate diagnosis.


Assuntos
Meios de Contraste , Imageamento por Ressonância Magnética , Compostos de Manganês , Compostos de Manganês/química , Compostos de Manganês/farmacologia , Animais , Camundongos , Meios de Contraste/química , Humanos , Campos Magnéticos , Glutationa/química , Óxidos/química , Linhagem Celular Tumoral , Glioma/diagnóstico por imagem , Glioma/patologia , Tamanho da Partícula , Nanopartículas de Magnetita/química
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