Neovaginoplasty With Nile Tilapia Skin: Cytological and Microbiota Evaluation.

OBJECTIVES: To study the clinical, cytological, and vaginal microbiota findings in patients with Mayer-Rokitansky-Küster-Hauser syndrome who underwent neovaginoplasty using Nile tilapia fish skin. METHODS: This is a cross-sectional study with 7 cisgender women with Mayer-Rokitansky-Küster-Hauser syndrome who had previously undergone neovagina reconstruction using Nile tilapia fish skin at a university hospital. Local institutional review board approval and written permission from the patient were obtained. Between August 2019 and November 2021, within 12 to 24 months after surgery, vaginal specimens were obtained for conventional oncotic and hormonal cytology, and for Gram staining. The Nugent scores were calculated. Colposcopy was also performed. RESULTS: Squamous cells without atypia were found in all patients. Five patients had intermediate vaginal microbiota (Nugent score of 4), which was determined by the presence of few lactobacilli on Gram staining. In hormonal cytology, 4 patients presented with findings compatible with menacme. No colposcopic change was observed. When postsurgical dilation was performed correctly, a mean vaginal length of 8.3 cm was maintained after 1 year of follow-up. CONCLUSIONS: Squamous cells without atypia were present in neovaginas with Nile tilapia fish skin. Most vaginal contents revealed intermediate microbiota and hormonal results compatible with menacme. Studies with a greater number of patients are necessary for a more comprehensive understanding of the microbiome in neovaginas with this new technique, thereby providing support for the treatment and prevention of associated pathologies.

Dengue infection in children and adolescents: clinical profile in a reference hospital in northeast Brazil.

INTRODUCTION: This study aimed to describe the clinical spectrum of dengue in children and adolescents from a hyperendemic region who were admitted for hospitalization. METHODS: A retrospective study was conducted on patients diagnosed with dengue infection upon admission to a reference center in Fortaleza, Brazil. RESULTS: Of the 84 patients included, 42 underwent confirmatory testing. The main symptoms were fever, abdominal pain and vomiting. The median level of serum aspartate aminotransferase was 143.5±128mg/dL. CONCLUSIONS: A peculiar clinical profile was evident among children and adolescents with dengue infection in a reference center in northeast Brazil, including gastrointestinal symptoms and liver involvement.

Avaliação de manifestações dolorosas em pacientes internados em hospital de referência, com diagnóstico provisório de dengue / Falls in chronic pain elderly patients: prevalence and associated factor

JUSTIFICATIVA E OBJETIVOS: As manifestações álgicas são características marcantes da dengue, tanto em crianças como em adultos, trazendo desconforto e sofrimentoa os pacientes. O objetivo deste estudo foi analisar as principais queixas dolorosas em pacientes acometidos por essa afecção, tornando possível a elaboração de medidas de diagnóstico precoce e manuseio da dor.MÉTODO: Estudo retrospectivo em 252 prontuários de pacientes com diagnóstico presuntivo de dengue, atendidos no Hospital São José de Fortaleza, referência em doenças infecciosas no estado do Ceará, no período de janeiro de 2006 a dezembro de 2007. Foram incluídos no estudo os pacientes que apresentaram ao menos uma queixa álgica. RESULTADOS: A maioria dos pacientes (94,84%) apresentou ao menos uma queixa álgica, sendo a cefaleia a mais prevalente, seguida por mialgia e dor abdominal. Os pacientes diagnosticados com febre hemorrágica da dengue (40,16%) cursaram com mais sintomas dolorosos que os pacientes com diagnóstico de dengue clássico. Sorologia para dengue foi positiva em 72,72% dos que apresentaram as cinco principais queixas álgicas analisadas no estudo. CONCLUSÃO: A dor mostrou-se bastante prevalente no quadro clínico da dengue, cabendo aos profissionais de saúde o manuseio adequado da sintomatologia álgica.

BACKGROUND AND OBJECTIVES: Pain manifestations are major dengue fever characteristics, both inadults and children, bringing discomfort and distress to patients. This study aimed at analyzing major pain complaints in dengue fever patients, thus making possible the development of early diagnosis and pain management.METHOD: Retrospective study of 252 medical recordsof patients with presumptive dengue fever diagnosis, treated at São José Hospital, Fortaleza, reference in infectious diseases in the State of Ceará, from January 2006 to December 2007. Patients presenting at least one paincomplaint were included in the study. RESULTS: Most patients (94.84%) had at least one pain complaint, being headache the most prevalent, followedby myalgia and abdominal pain. Patients diagnosed with hemorrhagic dengue fever (40.16%) had more pain complaints than patients with classic dengue fever. Serology for dengue fever was positive for 72.72% of patients presenting the five major pain complaints evaluated in this study.CONCLUSION: Pain was highly prevalent in denguefever cases and health professionals should adequately manage pain symptoms.