RESUMO
An equation for accurate estimation of the glomerular filtration rate (GFR) is vital for staging and directing the treatment of chronic kidney disease (CKD), which is a source of considerable morbidity and mortality around the world. The Modification of Diet for Renal Disease (MDRD) equation, which includes a racial coefficient, is commonly used. The MDRD equation has been validated in Caucasian populations, but modifying the racial coefficient for Asian countries has resulted in substantially different values that may not be due to race alone. Moreover, it is sometimes difficult to define race, particularly in multi-ethnic populations and among offspring of inter-ethnic marriages. Furthermore, the precision of the MDRD equation is poorer at the early stages of CKD. New markers, such as cystatin C, and new equations may be needed to accurately assess wider ranges of GFR in multi-ethnic countries. We review the development of GFR-estimating equations from an Asian perspective.
Assuntos
Creatinina/análise , Cistatina C/análise , Falência Renal Crônica/diagnóstico , Testes de Função Renal , Rim/patologia , Ásia , Povo Asiático , Biomarcadores , Taxa de Filtração Glomerular , Humanos , Falência Renal Crônica/etnologia , Falência Renal Crônica/patologiaRESUMO
Gemella morbillorum is part of the commensal flora of the upper respiratory tract, intestinal tract and genitourinary tract. On rare occasions, it causes endocarditis. We report a 67-year-old Chinese man with end-stage renal disease on maintenance intermittent haemodialysis, who developed Gemella morbillorum endocarditis complicated by severe aortic and mitral regurgitation. Most cases of Gemella morbillorum endocarditis have satisfactory outcomes with antibiotics or surgical treatment.