Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy.

Electrophysiological monitoring of saccadic eye movements in patients with hypoxic-ischemic encephalopathy (HIE) was carried out. Externally guided saccades (prosaccades) were recorded using a patented hardware-software complex for studying the subject's physical activity. Recordings were performed in two independent experimental procedures - for saccades separately and when they were in coordination with the motion of head and hand. In both cases statistically significant differences in latent periods and durations of saccadic eye movements were noticed in HIE patients in comparison with healthy subjects of the same age group (p<0.05). Jerking and deviation of eyes after fixing the gaze on a target were often present in HIE participants. In some cases saccades of patients were asymmetrical among themselves. We found HIE induced changes in the parameters of autosaccades as well, expressed through the instability of gaze fixation periods, sometimes asymmetric eye movements, slow gaze shift from one target to another and disturbance of gaze stabilization (as jerking of the eyeballs during the saccadic period).

Hardware-program complex for inspection of eyes, head and hand movements coordination of the man.

It is presented hardware- program complex for eyes, head and hand separate movement's check-up, and their coordination check-up in the integrated movement act. Patients with movement disorders are surveyed by using this complex. As an example there are shown differences in movement parameters value (a stage of latency, duration, frequency etc.), of patients with different stages of Parkinson disease (PD) by using several tests. Analysis of head, eyes and hand movement's trajectories can be used for early PD diagnostics.