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1.
Opt Express ; 30(14): 25219-25233, 2022 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-36237057

RESUMO

We report net gain measurements at room temperature in Al0.07Ga0.93N/GaN 10-period multi-quantum well layers emitting at 367 nm, using the variable stripe length method. The separate confinement heterostructure was designed targeting electron-beam pumped lasing at 10 kV. The highest net gain value was 131 cm-1, obtained at the maximum pumping power density of the experimental setup (743 kW/cm2). The net gain threshold was attained at 218 kW/cm2 using 193 nm optical pumping. From these experiments, we predict an electron-beam-pumped lasing threshold of 370 kW/cm2 at room temperature, which is compatible with the use of compact cathodes (e.g. carbon nanotubes). In some areas of the sample, we observed an anomalous amplification of the photoluminescence intensity that occurs for long stripe lengths (superior to 400 µm) and high pumping power (superior to 550 kW/cm2), leading to an overestimation of the net gain value. We attribute such a phenomenon to the optical feedback provided by the reflection from cracks, which were created during the epitaxial growth due to the strong lattice mismatch between different layers.

2.
Biomed Opt Express ; 13(12): 6484-6496, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36589564

RESUMO

We present in vivo ultrasound modulated optical tomography (UOT) results on mice, using the persistent spectral hole burning (PSHB) effect in a Tm3+:YAG crystal. Indocyanine green (ICG) solution was injected as an optical absorber and was clearly identified on the PSHB-UOT images, both in the muscle (following an intramuscular injection) and in the liver (following an intravenous injection). This demonstration also validates an experimental setup with an improved level of performance combined with an increased technological maturity compared to previous demonstrations.

3.
Opt Express ; 29(9): 13084-13093, 2021 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-33985051

RESUMO

We present a study of undoped AlGaN/GaN separate confinement heterostructures designed to operate as electron beam pumped ultraviolet lasers. We discuss the effect of spontaneous and piezoelectric polarization on carrier diffusion, comparing the results of cathodoluminescence with electronic simulations of the band structure and Monte Carlo calculations of the electron trajectories. Carrier collection is significantly improved using an asymmetric graded-index separate confinement heterostructure (GRINSCH). The graded layers avoid potential barriers induced by polarization differences in the heterostructure and serve as strain transition buffers which reduce the mosaicity of the active region and the linewidth of spontaneous emission.

4.
Chem Biodivers ; 17(9): e2000303, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32592287

RESUMO

A new decenoic acid derivative, gelliodesinic acid, and a naturally new alkaloid, together with three known furanoterpenoids and two known indole alkaloids, were isolated from the MeOH extract of the marine sponge Gelliodes sp. collected in Vietnam. The chemical structures of the isolated compounds were determined by analyses of 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The cytotoxicity assay against HeLa, MCF-7, and A549 cancer cell lines revealed that the three known furanoterpenes exhibited cytotoxic activities with IC50 values ranging from 23.6 to 75.5 µM against the three cell lines, and that 1H-indole-3-carboxylic acid showed cytotoxicity with an IC50 value of 89.2 µM against A549 cancer cell lines.


Assuntos
Alcaloides/farmacologia , Antineoplásicos/farmacologia , Ácidos Graxos/farmacologia , Poríferos/química , Alcaloides/química , Alcaloides/isolamento & purificação , Animais , Antineoplásicos/química , Antineoplásicos/isolamento & purificação , Proliferação de Células/efeitos dos fármacos , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Ácidos Graxos/química , Ácidos Graxos/isolamento & purificação , Estrutura Molecular , Relação Estrutura-Atividade , Células Tumorais Cultivadas , Vietnã
5.
Chem Biodivers ; 16(3): e1800593, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30548373

RESUMO

A new tribromoiododiphenyl ether (1) and eight known brominated diphenyl ethers (2-9) were isolated from the MeOH extract of the sponge Arenosclera sp. collected in Vietnam, using repeated open column chromatography and preparative thin layer chromatography. The chemical structure of the new compound 1 was determined by analyses of spectroscopic (1D- and 2D-NMR, and MS) data and by comparison of our data with those reported in the literature. Compounds 1, 3, and 8 exhibited strong antibacterial activities against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus and the Gram-negative bacterium Klebsiella pneumoniae with MIC values ranging from 0.8 to 6.3 µm, while compounds 5 and 7 only displayed activities against Gram-positive bacteria with MIC values from 0.5 to 3.1 µm. Compound 2 showed activities against the four tested bacteria with MIC values ranging from 0.5 to 6.3 µm.


Assuntos
Antibacterianos/farmacologia , Bacillus subtilis/efeitos dos fármacos , Éteres Difenil Halogenados/farmacologia , Klebsiella pneumoniae/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos , Animais , Antibacterianos/química , Antibacterianos/isolamento & purificação , Relação Dose-Resposta a Droga , Éteres Difenil Halogenados/química , Éteres Difenil Halogenados/isolamento & purificação , Testes de Sensibilidade Microbiana , Estrutura Molecular , Poríferos , Relação Estrutura-Atividade
6.
Opt Express ; 26(25): 32500-32508, 2018 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-30645416

RESUMO

We demonstrate lasing up to 230 K in a GeSn heterostructure micro-disk cavity. The GeSn 16.0% optically active layer was grown on a step-graded GeSn buffer, limiting the density of misfit dislocations. The lasing wavelengths shifted from 2720 to 2890 nm at 15 K up to 3200 nm at 230 K. Compared to results reported elsewhere, we attribute the increase in maximal lasing temperature to two factors: a stronger optical confinement by a thicker active layer and a better carrier confinement provided by a GeSn 13.8% / GeSn 16.0% / GeSn 13.8% double heterostructure.

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