Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 14 de 14
Filtrar
1.
J Acad Nutr Diet ; 124(9): 1214-1221, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38554945

RESUMO

BACKGROUND: MyPlate is a tool designed to educate the general US population on how to eat in alignment with the Dietary Guidelines for Americans; yet, there is a lack of data on who has heard of MyPlate over time. OBJECTIVE: The objective of this analysis was to examine the prevalence of awareness of MyPlate within the US population and if awareness changes differentially over time. DESIGN: This study was a serial, cross-sectional survey. PARTICIPANTS/SETTING: Three survey waves of data (2013-2018) were used from the National Health and Nutrition Examination Survey of adults aged 20 years or older (n = 17,023). MAIN OUTCOME MEASURES: Percentage of the US adult population who had heard of MyPlate was measured and stratified by sex, age, citizenship status, education, household food security status, income, receipt of Supplemental Nutrition Assistance Program (SNAP) benefits, and receipt of Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) benefits. STATISTICAL ANALYSES PERFORMED: Global Wald tests were used to assess whether prevalence of awareness of MyPlate differed by sociodemographic characteristics. Tests of homogeneity using likelihood ratio tests of nested logistic regression models were used to assess whether differences in awareness of MyPlate by various sociodemographic characteristics changed over time from 2013 to 2018. RESULTS: Twenty percent (19.5%) (n = 875) of the analytic sample of participants aged 20 years and older had heard of MyPlate in 2013-2014, 24.5% (n = 1,020) in 2015-2016, and 24.6% (n = 1,086) in 2017-2018. Awareness of MyPlate changed differentially over time (P value < .1) from 2013 to 2018 by income, household food security status, and receipt of SNAP benefits, with slower increases in awareness for households with lowest income over time, narrowing of differences in awareness by household food security status over time, and persistent differences in awareness by receipt of SNAP benefits over time. CONCLUSIONS: These results highlight the current low awareness of MyPlate, disparities in awareness of MyPlate immediately after implementation by sociodemographic characteristics, and increases in awareness over time at differential rates within levels of income, food security status, and ever receipt of SNAP benefits. Given that the Dietary Guidelines for Americans 2025-2030 are currently in development, new strategies should be considered to disseminate tools that translate the updated Dietary Guidelines in such a way that reach the general population equitably upon implementation within the United States.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Política Nutricional , Inquéritos Nutricionais , Humanos , Feminino , Adulto , Masculino , Estudos Transversais , Estados Unidos , Pessoa de Meia-Idade , Adulto Jovem , Idoso , Dieta Saudável/estatística & dados numéricos , Dieta Saudável/psicologia , Assistência Alimentar/estatística & dados numéricos , Conscientização
2.
Artigo em Inglês | MEDLINE | ID: mdl-34574668

RESUMO

With limited COVID-19-guidelines for institutions of higher education (IHEs), colleges and universities began the 2020-2021 academic year with varying approaches. We present a comprehensive COVID-19 prevention and mitigation approach at a residential university during the 2020-2021 academic year, along with campus SARS-CoV-2 transmission during this time. Risk management of COVID-19 was facilitated through (1) a layered approach of primary, secondary, and tertiary prevention measures; (2) a robust committee structure leveraging institutional public health expertise; (3) partnerships with external health entities; and (4) an operations system providing both structure and flexibility to adapt to changes in disease activity, scientific evidence, and public health guidelines. These efforts collectively allowed the university to mitigate SARS-CoV-2 transmission on campus and complete the academic year offering in-person learning on a residential campus. We identified 36 cases of COVID-19 among the 2037 in-person learners during the fall semester, 125 cases in the inter-semester break, and 169 cases among 2095 in-person learners during the spring semester. SARS-CoV-2 infection during the academic year was associated with gender (p = 0.04), race/ethnicity (p = 0.01), and sorority/fraternity membership (p < 0.01). Infection was not associated with undergraduate vs. graduate student status, Division I athlete status, or housing type (all p > 0.05). A multi-faceted public health approach was critical for reducing the impact of COVID-19 while carrying out the university's educational mission.


Assuntos
COVID-19 , Humanos , Gestão de Riscos , SARS-CoV-2 , Estudantes , Universidades
3.
J Diabetes Complications ; 34(12): 107709, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32888787

RESUMO

AIMS: We studied the association of three distinct diet quality indices and two measures of arterial stiffness in youth and young adults (YYA) aged 10 to 30 with T1D. METHODS: Cross-sectional (n = 1421) and longitudinal (n = 520) analyses were conducted in T1D YYA participating in the SEARCH for Diabetes in Youth Study. The diet quality indices included the Dietary Approaches to Stop Hypertension (DASH) index, the Healthy Eating Index 2015 (HEI-2015), and a modified Mediterranean Diet Quality Index (mKIDMED). Arterial stiffness was measured with pulse wave velocity (PWV) and augmentation index (AIx) obtained using a SphygmoCor-Vx device and tonometer. RESULTS: Average diet quality was moderate to poor, with mean scores of 41 (DASH, range 0-80), 55 (HEI-2015, range 0-100), 3.7 (mKIDMED, range - 3-12). None of the diet quality scores was associated with the central PWV or Aix, independent of demographic, clinical and lifestyle factors, body mass index and HbA1c. Longitudinal data yielded consistent findings with cross-sectional results. CONCLUSIONS: This study suggests that diet quality may not function as an independent risk factor for arterial stiffening in YYA with T1D. These findings do not diminish the importance of consuming a quality diet for the management of diabetes, as demonstrated in previous work.


Assuntos
Diabetes Mellitus Tipo 1 , Dieta Mediterrânea , Rigidez Vascular , Adolescente , Criança , Estudos Transversais , Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 1/dietoterapia , Diabetes Mellitus Tipo 1/epidemiologia , Humanos , Estudos Longitudinais , Análise de Onda de Pulso , Adulto Jovem
4.
Pediatr Diabetes ; 21(7): 1093-1101, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32737919

RESUMO

AIMS: Examine associations of dietary strategies used to manage diabetes over time with hemoglobin A1c in youth-onset type 1 or type 2 diabetes. METHODS: The SEARCH for Diabetes in Youth observational study assessed dietary strategies used by 1814 participants with diabetes (n = 1558 type 1, n = 256 type 2) at two to three research visits over 5.5 years (range 1.7-12.2). Participants reported often, sometimes, or never using 10 different dietary strategies, and use over time was categorized into five mutually exclusive groups: often using across visits; started using at later visits; sometimes using across visits; stopped using at later visits; or never using across visits. General multivariable linear models evaluated most recent A1c by use category for each strategy. RESULTS: In type 1 diabetes, A1c was lower among those who starting tracking calories (-0.4%, Tukey P < .05), often counted carbs (-0.8%, Tukey P < .001), or sometimes chose low glycemic index foods (-0.5%, Tukey P = .02) vs those with less use, while participants who never drank more milk had the lowest A1c (-0.5%, Tukey P = .04). In type 2 diabetes, A1c was lower among those who often limited high fat foods (-2.0%, Tukey P = .02) or started counting carbohydrates (-1.7%, Tukey P = .07) than those who did so less. CONCLUSIONS: For several dietary strategies, more frequent use over time was related to lower A1c in youth-onset type 1 and type 2 diabetes, suggesting these strategies can likely support diabetes management for this population. Investigation into factors predicting receipt of advice for specific strategies and corresponding impact on intake might be considered.


Assuntos
Diabetes Mellitus Tipo 1/terapia , Diabetes Mellitus Tipo 2/terapia , Dieta , Controle Glicêmico , Adolescente , Fatores Etários , Glicemia , Criança , Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 2/sangue , Comportamento Alimentar , Hemoglobinas Glicadas/metabolismo , Humanos , Autorrelato , Fatores de Tempo , Estados Unidos , Adulto Jovem
5.
Nutrients ; 12(4)2020 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-32231085

RESUMO

Traditionally, nutritional epidemiologists have utilized single nutrient or dietary pattern approaches to examine diet-health relationships. However, the former ignores that nutrients are consumed from foods within dietary patterns, and, conversely, dietary patterns may provide little information on mechanisms of action. Substitution provides a framework for estimating diet-health relationships while holding some nutrient intakes constant. We examined substitution effects of polyunsaturated fatty acids (PUFAs) in the SEARCH Nutrition Ancillary Study in the context of food group source. PUFAs were calculated from fatty acids 18:3, 20:5, and 22:6 (n-3), and 18:2 and 20:4 (n-6) from a food frequency questionnaire, quantified by food group. Models were adjusted for other fat intake, carbohydrates, protein, age, race, gender, and diabetes duration. Participants (n = 1441) were 14 years old on average, 51% female, with type 1 diabetes for 3.6 years. Mean intake of PUFAs was 14.9 g/day, and the highest PUFA sources were nonsolid fats, nuts, grains, red/processed meats, sweets/desserts, and high-fat chicken. PUFAs from nuts were inversely associated with low-density lipoprotein cholesterol (LDL) (p = 0.03) and PUFAs from high-fat chicken were positively associated with LDL (p < 0.01). Substituting nuts for chicken was associated with -7.4 mg/dL in LDL. These findings illustrate the importance of considering food group-based sources of nutrients when examining diet-health relationships.


Assuntos
Fenômenos Fisiológicos da Nutrição do Adolescente , LDL-Colesterol/metabolismo , Diabetes Mellitus Tipo 1/metabolismo , Dieta Saudável , Ácidos Graxos Insaturados/administração & dosagem , Alimentos , Nutrientes , Adolescente , Animais , Galinhas , Feminino , Análise de Alimentos , Humanos , Masculino , Nozes , Produtos Avícolas , Prognóstico
6.
Nutrients ; 11(8)2019 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-31366063

RESUMO

The relationship between added sugar and arterial stiffness in youth with type 1 diabetes (T1D) has not been well-described. We used data from the SEARCH for Diabetes in Youth Study (SEARCH), an ongoing observational cohort study, to determine the association between added sugar and arterial stiffness in individuals diagnosed with T1D <20 years of age (n = 1539; mean diabetes duration of 7.9 ± 1.9 years). Added sugar intake was assessed by a food frequency questionnaire, and arterial stiffness measures included pulse wave velocity (PWV) and augmentation index. Separate multivariate linear regression models were used to evaluate the association between added sugar and arterial stiffness. Separate interaction terms were included to test for effect modification by body mass index (BMI) z-score and physical activity (PA). Overall, there was no association between added sugar and arterial stiffness (P > 0.05); however, the association between added sugar and arterial stiffness differed by BMI z-score (P for interaction = 0.003). For participants with lower BMI z-scores, added sugar intake was positively associated with PWV trunk measurements, whereas there was no association for those who had a higher BMI z-score. PA did not significantly modify the association between added sugar and arterial stiffness. Further research is needed to determine the longitudinal relationship and to confirm that obesity differentially affects this association.


Assuntos
Diabetes Mellitus Tipo 1/patologia , Carboidratos da Dieta/administração & dosagem , Açúcares/administração & dosagem , Rigidez Vascular , Adolescente , Índice de Massa Corporal , Estudos de Coortes , Ingestão de Alimentos , Exercício Físico , Feminino , Humanos , Masculino , Adulto Jovem
7.
J Diabetes Complications ; 32(2): 179-184, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29198994

RESUMO

BACKGROUND: Systemic inflammation is a key process underlying cardiovascular disease (CVD) development, and CVD risk is significantly elevated in persons with type 1 diabetes (T1D). Youth with T1D exhibit increased levels of inflammation. Studies in persons without diabetes suggest that dietary quality influences inflammation, yet little is known about dietary influences on inflammation in youth with T1D. METHODS: This study evaluated the association of four distinct dietary quality indices (Dietary Approaches to Stop Hypertension (DASH), Healthy Eating Index 2010 (HEI2010), modified KIDMED and Total Antioxidant Capacity (TAC)) with biomarkers of inflammation (C-reactive protein (CRP), fibrinogen and interleukin-6 (IL-6)) in a sample of 2520 youth with T1D participating in the SEARCH for Diabetes in Youth Study. RESULTS: Average diet quality was moderate to poor, with mean scores of 43 (DASH, range 0-80), 55 (HEI2010, range 0-100), 3.7 (mKIDMED, range 3-12) and 7237 (TAC). None of the four diet quality scores was associated with the selected biomarkers of inflammation in any analyses. Evaluation of a non-linear relationship or interactions with BMI or levels of glycemic control did not alter the findings. Replication of analyses using longitudinal data yielded consistent findings with our cross-sectional results. CONCLUSIONS: Biomarkers of inflammation in youth with T1D may not be directly influenced by dietary intake, at least at the levels of dietary quality observed here. More work is needed to understand what physiologic mechanisms specific to persons with T1D might inhibit the generally beneficial influence of high dietary quality on systemic inflammation observed in populations without diabetes.


Assuntos
Biomarcadores/sangue , Diabetes Mellitus Tipo 1 , Dieta , Inflamação/sangue , Valor Nutritivo , Adolescente , Antioxidantes/metabolismo , Proteína C-Reativa/metabolismo , Criança , Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 1/epidemiologia , Dieta/estatística & dados numéricos , Inquéritos sobre Dietas , Comportamento Alimentar/fisiologia , Feminino , Humanos , Masculino
8.
J Nutr Educ Behav ; 45(6): 661-8, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23891147

RESUMO

OBJECTIVES: To examine whether the types of medical nutrition therapies (MNTs) taught to and used by youth with type 1 diabetes (T1D) vary by sociodemographic characteristics and cardiovascular (CVD) risk factors. DESIGN: Cross-sectional study. SETTING: The SEARCH for Diabetes in Youth study is a population-based cohort of individuals with clinical diagnosed diabetes. PARTICIPANTS: A total of 1,191 individuals with T1D. MAIN OUTCOME MEASURES: Types of MNTs and frequency of use. ANALYSIS: Bivariate analysis and multivariate linear regression (P < .05) RESULTS: More race/ethnic minorities (vs whites), individuals with parents with less than a high school education (vs high school or higher education), and overweight/obese (vs underweight/normal weight) were taught additional MNTs. For underweight/normal weight individuals exclusively taught carbohydrate counting, those who used this approach "often" had lower hemoglobin A1c (8.6% vs 8.9%) and triglycerides (73.5 vs 84.1 mg/dL) than those who used it "sometimes/never." "Often" use of additional MNTs beyond carbohydrate counting was not associated with better mean values for CVD risk factors. CONCLUSIONS AND IMPLICATIONS: In individuals with T1D, race/ethnic minorities, individuals with parents with less than a high school education, and overweight/obese individuals are taught more MNTs. Further research is needed to understand the effectiveness of the various MNTs on CVD risk factors, and to identify how to translate nutrition knowledge to behavior and metabolic status.


Assuntos
Pressão Sanguínea/fisiologia , Diabetes Mellitus Tipo 1 , Lipídeos/sangue , Terapia Nutricional , Adolescente , Criança , Pré-Escolar , Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 1/epidemiologia , Diabetes Mellitus Tipo 1/terapia , Feminino , Humanos , Lactente , Modelos Lineares , Masculino , Análise Multivariada , Fatores de Risco
9.
Diabetes Care ; 36(4): 865-72, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23223352

RESUMO

OBJECTIVE: The influence on diabetes of the timing and duration of obesity across the high-risk period of adolescence to young adulthood has not been investigated in a population-based, ethnically diverse sample. RESEARCH DESIGN AND METHODS: A cohort of 10,481 individuals aged 12-21 years enrolled in the U.S. National Longitudinal Study of Adolescent Health (1996) was followed over two visits during young adulthood (18-27 years, 2001-2002; 24-33 years, 2007-2009). Separate logistic regression models were used to examine the associations of diabetes (A1C ≥6.5% or diagnosis by a health care provider) in young adulthood with 1) obesity timing (never obese, onset <16 years, onset 16 to <18 years, onset ≥18 years) and 2) obesity duration over time (never obese, incident obesity, fluctuating obesity, and persistent obesity), testing differences by sex and race/ethnicity. RESULTS: Among 24- to 33-year-old participants, 4.4% had diabetes (approximately half were undiagnosed), with a higher prevalence in blacks and Hispanics than whites. In multivariable analyses, women who became obese before age 16 were more likely to have diabetes than women who became obese at or after age 18 (odds ratio 2.77 [95% CI 1.39-5.52]), even after accounting for current BMI, waist circumference, and age at menarche. Persistent (vs. adult onset) obesity was associated with increased likelihood of diabetes in men (2.27 [1.41-3.64]) and women (2.08 [1.34-3.24]). CONCLUSIONS: Diabetes risk is particularly high in individuals who were obese as adolescents relative to those with adult-onset obesity, thus highlighting the need for diabetes prevention efforts to address pediatric obesity.


Assuntos
Diabetes Mellitus Tipo 2/epidemiologia , Obesidade/epidemiologia , Adolescente , Adulto , Negro ou Afro-Americano , Criança , Diabetes Mellitus Tipo 2/etnologia , Feminino , Hispânico ou Latino , Humanos , Estudos Longitudinais , Masculino , Obesidade/etnologia , População Branca , Adulto Jovem
10.
JAMA ; 304(18): 2042-7, 2010 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-21063014

RESUMO

CONTEXT: Although the prevalence of obesity has increased in recent years, individuals who are obese early in life have not been studied over time to determine whether they develop severe obesity in adulthood, thus limiting effective interventions to reduce severe obesity incidence and its potentially life-threatening associated conditions. OBJECTIVE: To determine incidence and risk of severe obesity in adulthood by adolescent weight status. DESIGN, SETTING, AND PARTICIPANTS: A cohort of 8834 individuals aged 12 to 21 years enrolled in 1996 in wave II of the US National Longitudinal Study of Adolescent Health, followed up into adulthood (ages 18-27 years during wave III [2001-2002] and ages 24-33 years during wave IV [2007-2009]). Height and weight were obtained via anthropometry and surveys administered in study participants' homes using standardized procedures. MAIN OUTCOME MEASURES: New cases of adult-onset severe obesity were calculated by sex, race/ethnicity, and adolescent weight status. Sex-stratified, discrete time hazard models estimated the net effect of adolescent obesity (aged <20 years; body mass index [BMI] ≥95th percentile of the sex-specific BMI-for-age growth chart or BMI ≥30.0) on risk of severe obesity incidence in adulthood (aged ≥20 years; BMI ≥40.0), adjusting for race/ethnicity and age and weighted for national representation. RESULTS: In 1996, 79 (1.0%; 95% confidence interval [CI], 0.7%-1.4%) adolescents were severely obese; 60 (70.5%; 95% CI, 57.2%-83.9%) remained severely obese in adulthood. By 2009, 703 (7.9%; 95% CI, 7.4%-8.5%) non-severely obese adolescents had become severely obese in adulthood, with the highest rates for non-Hispanic black women. Obese adolescents were significantly more likely to develop severe obesity in young adulthood than normal-weight or overweight adolescents (hazard ratio, 16.0; 95% CI, 12.4-20.5). CONCLUSION: In this cohort, obesity in adolescence was significantly associated with increased risk of incident severe obesity in adulthood, with variations by sex and race/ethnicity.


Assuntos
Obesidade/classificação , Obesidade/epidemiologia , Adolescente , Adulto , Idade de Início , Peso Corporal , Criança , Estudos de Coortes , Feminino , Humanos , Incidência , Masculino , Obesidade/etnologia , Grupos Raciais , Risco , Índice de Gravidade de Doença , Fatores Sexuais , Estados Unidos/epidemiologia , Adulto Jovem
11.
Am J Epidemiol ; 172(5): 549-57, 2010 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-20688900

RESUMO

Sibling and twin study designs provide control for confounding factors that are typically unmeasured in traditional cohort studies. Using nationally representative data from the National Longitudinal Study of Adolescent Health collected at 3 visits during 1994-2002, the authors evaluated the longitudinal association between birth weight and later obesity in a traditional cohort study (n = 13,763; ages 11-21 years at baseline), controlling for sex, age, race/ethnicity, and parental education. Among persons with a nonobese mother, high birth weight (>4 kg) participants were more likely than normal birth weight (>/=2.5-

Assuntos
Peso ao Nascer , Obesidade/epidemiologia , Irmãos , Adolescente , Adulto , Índice de Massa Corporal , Criança , Fatores de Confusão Epidemiológicos , Feminino , Humanos , Estudos Longitudinais , Masculino , Fatores Sexuais , Fatores Socioeconômicos
12.
Obesity (Silver Spring) ; 18(9): 1801-4, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20035278

RESUMO

No longitudinal analyses using national data have evaluated the increase in obesity from adolescence into early adulthood. We examined obesity incidence, persistence, and reversal in a nationally representative cohort of US teens followed into their early 30s, using measured height and weight data, in individuals enrolled in wave II (1996; 12-21 years), wave III (2001; 17-26 years), and wave IV (2008 early release data; 24-32 years) of the National Longitudinal Study of Adolescent Health (N = 8,675). Obesity was defined as a BMI >or=95th percentile of the 2000 Centers for Disease Control/National Center for Health Statistics growth charts or >or=30 kg/m(2) for individuals <20 years and >or=30 kg/m(2) in individuals >or=20 years. In 1996, 13.3% of adolescents were obese. By 2008, obesity prevalence increased to 36.1%, and was highest among non-Hispanic black females (54.8%). Ninety percent of the obese adolescents remained obese in 2008. While annual obesity incidence did not decline in the total sample across the two study intervals (2.3% per year 1996-2001 vs. 2.2% per year 2001-2008), rates among white females declined (2.7 to 1.9% per year) and were highest among non-Hispanic black and Hispanic females (3.8 and 2.7% per year, 1996-2001 vs. 3.0 and 2.6% per year, 2002-2008, respectively). Obesity prevalence doubled from adolescence to the early 20s, and doubled again from the early to late 20s or early 30s, with strong tracking from adolescence into adulthood. This trend is likely to continue owing to high rates of pediatric obesity. Effective preventive and treatment efforts are critically needed.


Assuntos
Índice de Massa Corporal , Obesidade/epidemiologia , Adolescente , Adulto , Negro ou Afro-Americano , Criança , Feminino , Humanos , Estudos Longitudinais , Masculino , Obesidade/etnologia , Prevalência , Distribuição por Sexo , Estados Unidos/epidemiologia , População Branca , Adulto Jovem
13.
Obesity (Silver Spring) ; 17(7): 1441-7, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19360012

RESUMO

BMI is highly correlated between spouses; however, less is understood about the underlying mechanism(s) by which the development of obesity in one individual increases the risk of obesity in his/her spouse. The objective of this study is to investigate whether romantic partnership and duration of cohabitation are related to incident obesity and obesity-promoting behaviors. We used two data sets from the National Longitudinal Study of Adolescent Health: (i) 6,949 US adolescents (wave II, 1996) followed into adulthood (wave III, 2001-2002) and (ii) 1,293 dating, cohabiting, and married romantic couples from wave III, including measured anthropometry and self-report behavior data. In the longitudinal cohort, we used sex-stratified logistic regression models to examine the risk of incident obesity by longitudinal romantic relationship status and duration of time spent living with a romantic partner. In the Couples Sample, we used multinomial logistic regression to predict concordance in outcomes: obesity, moderate-to-vigorous physical activity, and screen time by romantic partnership and duration of time living with a romantic partner. Individuals who transitioned from single/dating to cohabiting or married were more likely to become obese than those who were dating at both waves. Partner concordance for negative, obesity-related behaviors was strongest for married couples and couples who lived together > or =2 years. The shared household environment may increase the likelihood of becoming obese, influence partner concordance, and may be an important target for obesity intervention.


Assuntos
Obesidade/epidemiologia , Cônjuges , Adolescente , Adulto , Estudos de Coortes , Feminino , Comportamentos Relacionados com a Saúde , Humanos , Incidência , Modelos Logísticos , Estudos Longitudinais , Masculino , Estudos Prospectivos , Fatores de Risco , Adulto Jovem
14.
Am J Med Genet A ; 143A(19): 2274-84, 2007 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-17726689

RESUMO

Biliary atresia is a rare birth defect that affects 1 in 12,000 to 1 in 19,500 live births. We used data from the National Birth Defects Prevention Study, a multistate case-control study, to identify potential risk factors for isolated biliary atresia (no additional unrelated major birth defects diagnosed). Infants were identified from eight states from 1997 to 2002, with clinical information abstracted from medical records. Potential risk factors assessed include: demographic factors, seasonality, preterm birth, maternal smoking, maternal alcohol use, maternal illicit drug use, maternal health, maternal medication use, maternal vitamin use, and maternal nutrition. Infants of non-Hispanic black mothers were more likely to have biliary atresia than infants of non-Hispanic white mothers (adjusted odds ratio (aOR) = 2.29, 95% confidence interval (CI) 1.07-4.93) and infants conceived during the spring season were more likely to have biliary atresia than infants conceived in winter (aOR = 2.33, 95%CI 1.05-5.16). Low intakes of vitamin E, copper, phosphorus, and beta tocopherol were associated with the occurrence of isolated biliary atresia (borderline significance). Low iron intake had a borderline inverse association with biliary atresia. While this analysis provides support for previous reports of a possible association between seasonal variation and the occurrence of biliary atresia, more data are needed to evaluate whether the seasonal variation is related to infectious agents. The role of nutrients in the development of biliary atresia remains unclear. Further studies of genetic, infectious, and nutrient exposures and the association of biliary atresia are warranted.


Assuntos
Atresia Biliar/epidemiologia , Anormalidades Congênitas/prevenção & controle , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Fatores de Risco
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA