Deep learning system for paddy plant disease detection and classification.

Automatic detection and analysis of rice crop diseases is widely required in the farming industry, which can be utilized to avoid squandering financial and other resources, reduce yield losses, and improve treatment efficiency, resulting in healthier crop output. An automated approach was proposed for accurately detecting and classifying diseases from a supplied photograph. The proposed system for the recognition of rice plant diseases adopts a computer vision-based approach that employs the techniques of image processing, machine learning, and deep learning, reducing the reliance on conventional methods to protect paddy crops from diseases like bacterial leaf blight, false smut, brown leaf spot, rice blast, and sheath rot, the five primary diseases that frequently plague the Indian rice fields. Following image pre-processing, image segmentation is employed to determine the diseased section of the paddy plant, with the diseases listed above being identified purely on the basis of their visual contents. An integration of a support vector machine classifier and convolutional neural networks are used to recognize and classify specific varieties of paddy plant diseases. With ReLU and softmax functions, the suggested deep learning-based strategy attained the highest validation accuracy of 0.9145. Following recognition, a predictive remedy is recommended, which can assist agriculture-related individuals and organizations in taking suitable measures to combat these diseases.

Effectiveness of reminiscence therapy in reducing agitation and depression and improving quality of life and cognition in long-term care residents with dementia: A systematic review and meta-analysis.

This paper assesses the effectiveness of reminiscence therapy (RT) in people with mild to moderate dementia in long-term care facilities. A literature search was conducted in CINAHL, MEDLINE, PsychINFO, and Embase from inception to December 2020. Five RCTs with 267 participants were included; two were meta-analysed. Cochrane collaboration's risk of bias tool was used to evaluate the methodological quality of the included RCTs, and the risk of bias across studies was assessed using the GRADE method. The overall quality of evidence was moderate to low. Among the five trials, none measured the efficacy of RT on agitation. Reminiscence therapy was effective in reducing depression and improving autobiographical memory, but its effects were inconsistent. There was a significant improvement in quality of life (QoL) following RT. The meta-analysis showed no statistical significance on the pre-post intervention differences in depression (SMD -0.28, 95%CI -0.91-0.35, p > 0.05) and autobiographical memory scores (SMD 0.57, 95%CI -0.07-1.21, p > 0.05). Reminiscence therapy may have some benefits in reducing depression and improving the QoL and cognition in this population; however, its effectiveness should be tested further.

Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders.

Device-based neuromodulation of brain circuits is emerging as a promising new approach in the study and treatment of psychiatric disorders. This work presents recent advances in the development of tools for identifying neurocircuits as therapeutic targets and in tools for modulating neurocircuits. We review clinical evidence for the therapeutic efficacy of circuit modulation with a range of brain stimulation approaches, including subthreshold, subconvulsive, convulsive, and neurosurgical techniques. We further discuss strategies for enhancing the precision and efficacy of neuromodulatory techniques. Finally, we survey cutting-edge research in therapeutic circuit modulation using novel paradigms and next-generation devices.

A double-blind pilot dosing study of low field magnetic stimulation (LFMS) for treatment-resistant depression (TRD).

BACKGROUND: Low field magnetic stimulation is a potentially rapid-acting treatment for depression with mood-enhancing effects in as little as one 20-min session. The most convincing data for LFMS has come from treating bipolar depression. We examined whether LFMS also has rapid mood-enhancing effects in treatment-resistant major depressive disorder, and whether these effects are dose-dependent. OBJECTIVE/HYPOTHESIS: We hypothesized that a single 20-min session of LFMS would reduce depressive symptom severity and that the magnitude of this change would be greater after three 20-min sessions than after a single 20-min session. METHODS: In a double-blind randomized controlled trial, 30 participants (age 21-65) with treatment-resistant depression were randomized to three 20-min active or sham LFMS treatments with 48 h between treatments. Response was assessed immediately following LFMS treatment using the 6-item Hamilton Depression Rating Scale (HAMD-6), the Positive and Negative Affect Scale (PANAS) and the Visual Analog Scale. RESULTS: Following the 3rd session of LFMS, the effect of LFMS on VAS and HAMD-6 was superior to sham (F (1, 24) = 7.45, p = 0.03, Bonferroni-Holm corrected; F (1, 22) = 6.92, p = 0.03, Bonferroni-Holm corrected, respectively). There were no differences between sham and LFMS following the initial or second session with the effect not becoming significant until after the third session. CONCLUSIONS: Three 20-min LFMS sessions were required for active LFMS to have a mood-enhancing effect for individuals with treatment-resistant depression. As this effect may be transient, future work should address dosing schedules of longer treatment courses as well as biomarker-based targeting of LFMS to optimize patient selection and treatment outcomes.

Synthesis of AuNPs@RGO nanosheets for sustainable catalysis toward nitrophenols reduction.

A facile, green and one-pot synthesis strategy for the convenient preparation of well-dispersed gold nanoparticles (AuNPs) decorated reduced graphene oxide (RGO) without using any other toxic chemicals and reductants is reported herein. The synthesized AuNPs@RGO hybrid nanomaterials were characterized by UV-visible absorption spectroscopy, FT-IR, XRD, Raman, SEM, TEM and EDX analysis. The AuNPs@RGO acts as an efficient catalyst for the reduction of organic nitroaromatics (2- & 4-nitro phenols) in the presence of NaBH4. This newly synthesized hybrid AuNPs@RGO has superior catalytic activity over any other Au-nanomaterials ever reported. The rate of nitro aromatics reduction is found to be dependent on concentrations of substrate, reductant and catalyst. The mechanisms for the synthesis and catalytic reduction have been studied and discussed.

Morphology dependent nonlinear optical and photocatalytic activity of anisotropic plasmonic silver.

Anisotropic nanoparticles are ideal building blocks for a number of functional materials due to their exceptional and anisotropic optical, electronic, magnetic and mechanical properties. In this work we present systematic studies on morphology dependent ultra-sensitive thermal diffusivity and photodegradation capability of anisotropic plasmonic silver for the first time. Hydrogen peroxide centered synthesis was performed to prepare anisotropic silver nanosystems spherical (14 nm), quasi-spherical (17 nm), elliptical (18 m), rods (aspect ratio 2.1), hexagonal (22 nm) and prisms (19 nm). The synthesized nanosystems were characterized using UV-VIS spectroscopy, high resolution transmission electron microscopy (HRTEM) and band gap analysis. A dual beam mode matched thermal lensing method was adopted for evaluating the thermal diffusivity of the anisotropic system. The present anisotropic nanoparticle system exhibited strong morphology based thermal diffusivity. An increase of 140% in the thermal diffusivity value points to the nonlinear optical application potential of the anisotropic systems. Sunlight mediated photodegradation of methylene blue showed a promising increase in the degradation rate for anisotropic systems compared to other similar systems reported in the literature.

Impact of intraoperative factor concentrates on blood product transfusions during orthotopic liver transplantation.

BACKGROUND: Major bleeding in orthotopic liver transplantation is associated with significant morbidity and mortality. Limited literature exists regarding comparative effectiveness of prothrombin complex concentrate and fibrinogen concentrate during orthotopic liver transplantation on blood product utilization. STUDY DESIGN AND METHODS: This retrospective, single-institution study evaluated the impact of prothrombin complex concentrate and fibrinogen concentrate on blood product utilization during orthotopic liver transplantation from December 2013 to April 2016. This study included patients age 18 years or older and excluded patients who received simultaneous heart or lung transplantation or did not meet documentation criteria. A propensity score matching technique was used to match patients who were exposed to prothrombin complex concentrate with unexposed patients, at a 2 to 1 ratio, to control for selection bias. RESULTS: During this study, 212 patients received orthotopic liver transplantation with 39 prothrombin complex concentrate exposures. The matched study population included 39 patients who were exposed to prothrombin complex concentrate and 78 unexposed patients. Overall, 84.6% of patients who were exposed to prothrombin complex concentrate also received concomitant fibrinogen concentrate, whereas only 2% of patients in the control group received fibrinogen concentrate. After propensity score matching, no other factors that were included in the model differed significantly or had a standardized mean difference of 0.11 or greater. There was no statistical difference in the utilization of red blood cells or fresh frozen plasma for the exposed group versus the unexposed group after matching (mean ± standard deviation: red blood cell units, 12.4 ± 8.0 units vs. 9.7 ± 5.6 units [p = 0.058]; fresh-frozen plasma units, 10.0 ± 6.3 vs. 12.7 ± 9.7 units [p = 0.119], respectively). CONCLUSION: The intraoperative use of prothrombin complex concentrate and fibrinogen concentrate during orthotopic liver transplantation did not reduce intraoperative blood product requirements at a single institution.

Supplementation of biotin to sperm preparation medium increases the motility and longevity in cryopreserved human spermatozoa.

PURPOSE: To study the effect of supplementing biotin to sperm preparation medium on the motility of frozen-thawed spermatozoa. METHODS: Semen samples of men attending the University infertility clinic (n = 105) were cryopreserved using glycerol-egg yolk-citrate buffered cryoprotective medium in liquid nitrogen. After a period of two weeks, the semen samples were thawed and the motile spermatozoa were extracted by swim-up technique using Earle's balanced salt solution (EBSS) medium supplemented with either biotin (10 nM) or pentoxifylline (1 mM). The post-wash motility was observed up to 4 h after incubation. RESULTS: Both biotin and pentoxifylline supplementation resulted in significant increase in total motility (p < 0.05), progressive motility (p < 0.001) and rapid progressive motility (p < 0.05 v/s biotin and p < 0.01 v/s pentoxifylline) compared to the control at 1 h post-incubation period. Significantly higher percentage of total (p < 0.01, p < 0.05 in biotin and pentoxifylline respectively), progressive (p < 0.001) and rapid progressive motilities (p < 0.01) were observed in these two groups even at 2 h compared to the control. In the control group at 4 h after incubation, ~11% decline in total motility and ~8% decline in progressive motility was observed. However, in both biotin and pentoxifylline group the motility was significantly higher than control (p < 0.001). No significant difference in the motility was observed between biotin and pentoxifylline groups at any of the time intervals studied. CONCLUSIONS: Biotin can enhance the sperm motility and prolong the survival of frozen-thawed semen samples which may have potential benefit in assisted reproductive technology field.