Measurements of Abdominal Obesity are Associated with Metabolic Syndrome Severity Independent of Hypertensive Phenotype in White but not Black Young Adults.

PURPOSE: This study sought to determine if metabolic syndrome severity (MetSindex) was differentially associated with abdominal obesity based on waist circumference (WC) site and the presentation of hypertensive phenotypes in a group of young White and Black adults. METHODS: A total of 139 young adult (22.5 ± 3.3 years) non-Hispanic White (n = 73) and non-Hispanic Black (n = 66) males and females (M 53, 86 F) completed this cross-sectional evaluation. Participants had their WC measured at three distinct locations along the abdomen which were used to calculate waist-to-hip and waist-to-height ratios. Systolic (SBP) and diastolic blood pressure (DBP) were collected and used to calculate mean arterial pressure (MAP). In addition to traditional metabolic syndrome (MetS) risk factors, BP values were individually used to produce three separate MetSindex scores representing three specific hypertensive phenotypes (MetSSBP, MetSDBP, MetSMAP), and each of these were evaluated against each abdominal obesity estimate. RESULTS: MetSDBP and MetSSBP were significantly higher than all other indices for females (all p ≤ 0.002) and males (all p < 0.001), respectively. MetSDBP was significantly higher than MetSMAP for White females (p = 0.039), and MetSSBP was significantly higher than MetSDBP and MetSMAP (both p < 0.001) for Black males. Standalone and joint estimates of abdominal obesity were uniquely associated with MetSindex across hypertensive phenotypes for White, but not Black males and females. CONCLUSIONS: Specific hypertensive phenotypes may differentially determine MetSindex, but these estimates are not associated with abdominal obesity in young Black adults regardless of measurement location. Healthcare professionals should address this disparity by providing more comprehensive MetS screening procedures for young Black adults. CLINICAL TRIALS REGISTRATION: NCT05885672.

Changes in Lower-Extremity Gait Biomechanics Following High-Cadence Cycling.

We sought to investigate the lower-extremity biomechanics underlying increased gait velocity following high-cadence cycling. Ground reaction forces (GRF) and lower-extremity kinematics and kinetics were recorded as 15 healthy adults walked at a self-selected pace prior to and immediately following a 15 min bout of cycling at a cadence of 75 rotations per minute. Propulsive GRF and stance-phase peak dorsiflexion and knee extension angles increased, while peak plantarflexion and hip extension angles decreased. Swing-phase peak dorsiflexion, plantarflexion, knee flexion, and hip flexion angles increased, while peak knee extension angle decreased. Peak dorsiflexion, knee extension, and hip extension angular velocity also increased during swing. No changes in peak joint moments were observed; however, peak positive ankle, knee, and hip joint power generation increased following cycling. Completing high-cadence cycling improves gait velocity by increasing propulsive GRF; increasing joint angular velocity during the swing phase of gait for the ankle, knee, and hip; and increasing positive power production by the ankle, knee, and hip during the stance phase. Increased gait velocity post cycling exercise did not increase lower-extremity joint moments. Cycling may be a viable exercise-based modality for increasing gait velocity, especially in populations where gait ability or joint loading is of particular concern.

Effects of shoe collar height and limb dominance on landing knee biomechanics in female collegiate volleyball players.

Volleyball-specific footwear with higher collar heights (a mid-cut shoe) are worn to restrict ankle motion. Reduced ankle dorsiflexion has been associated with increased frontal plane motion and injury risk at the knee. With the high frequency of unilateral landings in volleyball, the purpose of this study was to determine the effect of volleyball-specific shoes and limb dominance on knee landing mechanics in collegiate volleyball players. It was hypothesized that participants would exhibit smaller sagittal plane and greater frontal plane knee joint mechanics in mid-cut and dominant limb and that vertical and posterior directed ground reaction forces would be greater wearing mid-cut, yet similar between limbs. Seventeen female volleyball players performed unilateral landings on each limb in mid-cut and low-top volleyball shoes. For shoe main effects, smaller peak dorsiflexion angle and internal peak plantarflexion moment and greater peak medial ground reaction force were found in the mid-cut but with no impact on knee mechanics. For limb main effects, the internal peak knee abduction moment was greater in the dominant limb. Greater peak lateral ground reaction force was found in the interaction between the non-dominant limb and low-top. Further research is warranted to better understand shoe and limb impact in volleyball players.

Exploring gait velocity as a predictor of cardiometabolic disease risk in young adults.

Background: The association between poor gait and functional movement ability and metabolic syndrome (MetS) has been well established in older adults. A continuous cardiometabolic risk score, MetSindex, may more easily identify individuals at risk for cardiometabolic disease who do not yet meet the stringent criteria for a formal MetS diagnosis. Although the association between MetS and gait velocity is well established in older adults, no such relationship has been identified in younger adults; a group experiencing a rapid increase in the development of MetS. Methods: MetSindex was determined for 21 young adults using standard procedures. Gait velocity was measured as participants completed a ten-meter walk test. Spatiotemporal parameters of gait were also derived using a motion capture system. Simple linear regression was used to determine the relationship between MetSindex and gait velocity, as well as MetSindex and spatiotemporal parameters of gait. Results: There was a large inverse relationship between MetSindex and gait velocity. A large inverse relationship was also observed between MetSindex and cadence, and a large positive relationship was observed between stance time and double limb support time. Conclusions: Gait velocity slows in young adults who do not necessarily meet the criterion for positive diagnosis of MetS-but demonstrate an increased risk for MetS and cardiovascular disease through higher MetSindex scores. The mechanism underlying reduced gait velocity may be fewer, but not shorter steps. Determining easy-to-use surrogates of MetS (e.g., gait velocity) may help combat the growing prevalence of MetS by increasing access to preventative approaches.

High cadence cycling not high work rate, increases gait velocity post-exercise.

Gait velocity, or walking speed, has been referred to as the sixth vital sign, and research suggests that it is highly sensitive to change. Previous research has demonstrated the utility of cycling to improve gait parameters and in particular gait velocity in a variety of populations. However, it is unclear if the benefits from cycling to gait velocity stem from increased cadence, increased work rate, or the interaction between them. Therefore, the objective of the current research was to explicitly test the relationship between cycling work rate, cycling cadence, and gait velocity. 45 recreationally active young adults were randomly assigned to cycle at a normalised cadence and work rate, a higher cadence, or a higher work rate (CONTROL, FAST, HARD). All participants completed two ten-metre walk tests (10 MWT) pre- and post-cycling intervention. There was a significant interaction between group and time and post hoc comparisons showed that the FAST group walked significantly faster than the HARD group post-cycling. These results support the hypothesis that cycling at a cadence greater than the comfortable walking cadence, and not cycling at an increased work rate, increased gait velocity post-exercise for all members of our sample of healthy young adults.

Do Interlimb Knee Joint Loading Asymmetries Persist throughout Stance during Uphill Walking Following Total Knee Arthroplasty?

The purpose of this study was to determine differences in total (TCF), medial compartment (MCF), and lateral compartment (LCF) tibiofemoral joint compressive forces and related muscle forces between replaced and non-replaced limbs during level and uphill walking at an incline of 10°. A musculoskeletal modeling and simulation approach using static optimization was used to determine the muscle forces and TCF, MCF, and LCF for 25 patients with primary TKA. A statistical parametric mapping repeated-measures ANOVA was conducted on knee compressive forces and muscle forces using statistical parametric mapping. Greater TCF, MCF, and LCF values were observed throughout the loading response, mid-stance, and late stance during uphill walking. During level walking, knee extensor muscle forces were greater throughout the first 50% of the stance during level walking, yet greater during uphill walking during the last 50% of the stance. Conversely, knee flexor muscle forces were greater through the loading response and push-off phases of the stance. No between-limb differences were observed for compressive or muscle forces, suggesting that uphill walking may promote a more balanced loading of replaced and non-replaced limbs. Additionally, patients with TKA appear to rely on the hamstrings muscle group during the late stance for knee joint control, thus supporting uphill walking as an effective exercise modality to improve posterior chain muscle strength.

Tibiofemoral compressive force during downhill walking in patients with primary total knee arthroplasty: A statistical parametric mapping approach.

BACKGROUND: Downhill walking is a necessary part of daily life and an effective activity in post-operative rehabilitation following total knee arthroplasty. The purpose of this study was to determine differences in the behavior of total, medial, and lateral tibiofemoral compressive forces as well as knee extensor and flexor muscle forces between different limbs of patients with total knee arthroplasty (replaced, non-replaced) during downhill and level walking. METHODS: Musculoskeletal modeling and simulation were implemented to determine muscle forces and tibiofemoral compressive forces in 25 patients with total knee arthroplasty. A 2 × 2 [Limb (replaced, non-replaced) × Slope (0°, 10°)] Statistical parametric mapping repeated measures analysis of variance was conducted on selected variables. FINDINGS: Statistical parametric mapping did not identify any between-limb differences for compressive or muscle forces. Differences in joint compressive and muscle forces persisted throughout different intervals of stance-phase between level and downhill walking. Knee extensor muscle forces were distinctly greater during level walking for nearly all of stance phase. Knee flexor muscle force was greater during downhill walking for >60% of stance. Statistical parametric mapping did identify regions of significance between level and downhill walking that coincided temporally (near loading response and push off) with peak joint moment and joint compressive forces traditionally reported using discrete variable analyses. INTERPRETATION: Downhill walking may be a safe and useful rehabilitation tool for post-knee arthroplasty rehabilitation that will not disproportionally load either the replaced or the non-replaced joint and where the quadriceps muscles can be strengthened during a gait-specific task.

Can changes of workrate and seat position affect frontal and sagittal plane knee biomechanics in recumbent cycling?

Changes in the workrate and seat position have been linked to changes in internal knee extension moment. However, there is limited research on effects of those changes on knee kinetics in recumbent bike. The purpose of this study was to examine the effects of different seat positions and workrates on KAbM, knee extension moment and perceived effort during stationary recumbent cycling. Fifteen cyclists cycled on a recumbent ergometer in 6 test conditions of pedalling in far, medium and close seat positions in each of the two workrates of 60 and 100 W at the cadence of 80 RPM. A three-dimensional motion analysis system and a pair of instrumented pedals collected kinematic and kinetic data. A 3 ×2 repeated measures ANOVA was used to examine the effect of seat positions and workrates on selected variables of interest. Different seat positions did not change either peak KAbM (p = 0.592) or knee extension moment (p = 0.132). Increased workrates significantly increased peak KAbM (p <0.001 and ηp2 =0.794) and knee extension moment (p <0.001 and ηp2=0.722). This study showed that the far or close seat position did not increase frontal-plane or overall knee joint loading and provided evidence for prescribing recumbent bike for healthy population.

Medial and Lateral Tibiofemoral Compressive Forces in Patients Following Unilateral Total Knee Arthroplasty During Stationary Cycling.

Patients following unilateral total knee arthroplasty (TKA) display interlimb differences in knee joint kinetics during gait and more recently, stationary cycling. The purpose of this study was to use musculoskeletal modeling to estimate total, medial, and lateral tibiofemoral compressive forces for patients following TKA during stationary cycling. Fifteen patients of unilateral TKA, from the same surgeon, participated in cycling at 2 workrates (80 and 100 W). A knee model (OpenSim 3.2) was used to estimate total, medial, and lateral tibiofemoral compressive forces for replaced and nonreplaced limbs. A 2 × 2 (limb × workrate) and a 2 × 2 × 2 (compartment × limb × workrate) analysis of variance were run on the selected variables. Peak medial tibiofemoral compressive force was 23.5% lower for replaced compared to nonreplaced limbs (P = .004, G = 0.80). Peak medial tibiofemoral compressive force was 48.0% greater than peak lateral tibiofemoral compressive force in nonreplaced limbs (MD = 344.5 N, P < .001, G = 1.6) with no difference in replaced limbs (P = .274). Following TKA, patients have greater medial compartment loading on their nonreplaced compared to their replaced limbs and ipsilateral lateral compartment loading. This disproportionate loading may be cause for concern regarding exacerbating contralateral knee osteoarthritis.

Are Medial and Lateral Tibiofemoral Compressive Forces Different in Uphill Compared to Level Walking for Patients Following Total Knee Arthroplasty?

The purpose of this study was to determine how tibiofemoral joint compressive forces and knee joint-spanning muscle forces during uphill walking change compared to level walking in patients with total knee arthroplasty (TKA). A musculoskeletal model capable of resolving total (TCF), medial (MCF), and lateral (LCF) tibiofemoral compressive forces was used to determine compressive forces and muscle forces during level and uphill walking on a 10 deg incline for twenty-five post-TKA patients. A 2 × 2 (slope: level and 10 deg × limb: replaced and nonreplaced) repeated measures analysis of variance was used to detect differences in knee contact forces between slope and limb conditions and their interaction. Peak loading-response TCF, MCF, and LCF were greater during uphill walking than level walking for nonreplaced limbs. During uphill walking, peak loading-response TCF was smaller in replaced limbs compared to nonreplaced limbs with no change in MCF or LCF. Peak knee extension moment and knee extensor muscle force were smaller in replaced limbs compared to nonreplaced limbs during uphill walking. During level walking, replaced and nonreplaced limbs experienced rather equal joint loading; however, replaced limb experienced reduced joint loading during uphill walking. Differences in joint loading between replaced and nonreplaced limbs were not present during level walking, suggesting compensation from the replaced limb during the more difficult task. Uphill walking following TKA promotes more balanced loading of replaced limbs during stance; however, these benefits may come at the expense of increased loading on nonreplaced limbs.

Increased Q-factor increases medial compartment knee joint contact force during cycling.

As Q-Factor (QF: inter-pedal distance) is increased, the internal knee abduction moment (KAbM) also increases, however it is unknown if this increased KAbM is associated with increased medial compartment knee joint contact force in cycling. In the absence of in vivo measurement, musculoskeletal modeling simulations may provide a viable option for estimating knee joint contact forces in cycling. The primary purpose of this study was to investigate the effect of increasing QF on knee joint total (TCF), and medial (MCF) compartment contact force during ergometer cycling. The secondary purpose was to evaluate whether KAbM and knee extension moment are accurate predictors of MCF in cycling. Musculoskeletal simulations were performed to estimate TCF and MCF for sixteen participants cycling at an original QF (150 mm), and wide QF (276 mm), at 80 W and 80 rotations per minute. Paired samples t-tests were used to detect differences between QF conditions. MCF increased significantly, however, TCF did not change at wide QF. Peak knee extensor muscle force did not change at wide QF. Peak knee flexor muscle force was significantly reduced with wide QF. Regression analyses showed KAbM and knee extension moments explained 87.4% of the variance in MCF when considered alongside QF. The increase of MCF may be attributed to increased frontal-plane pedal reaction force moment arm. Future research may seek to implement QF modulation as a part of rehabilitation or training procedures utilizing cycling in cases where medial compartment joint loading is of importance.

Does saddle height influence knee frontal-plane biomechanics during stationary cycling?

INTRODUCTION: Cycling is a common modality for rehabilitation and exercise. However, there is a lack of information in the literature on the effects of saddle height adjustments on internal peak knee abduction moment, which is an important loading variable for the medial compartment of tibiofemoral joint for patients with knee osteoarthritis. The purpose of this study was to examine effects of saddle height on frontal-plane biomechanics of the knee during cycling. METHODS: Fourteen recreational cyclists (age: 57.1 ± 6.37 years) performed 2-min bouts of cycling at three saddle heights of 40°, 30° and 20° knee extension angle at bottom crank position, at two workrates of 80 and 120 W. Three-dimensional kinematic, kinetic, and electromyography data were collected and analyzed using a 3 × 2 (height × workrate) analysis of variance (ANOVA). RESULTS: There were no changes in internal knee abduction moment across saddle heights. Increases in saddle height from 40° to both 30° and 20° reduced the knee extension moment (d = 0.3 and 0.4, respectively, P = 0.012). Increases in workrate increased both knee abduction and extension moments (η2p = 0.75 and 0.88, respectively, P < 0.001 for both). CONCLUSIONS: Increased knee extension moment with decreased saddle height is likely to indicate increased knee joint load.

Knee joint biomechanics of patients with unilateral total knee arthroplasty during stationary cycling.

Stationary cycling is typically recommended following total knee arthroplasty (TKA) operations. However, knee joint biomechanics during cycling remains mostly unknown for TKA patients. Biomechanical differences between the replaced and non-replaced limb may inform applications of cycling in TKA rehabilitation. The purpose of this study was to examine the knee joint biomechanics of TKA patients during stationary cycling. Fifteen TKA participants cycled at 80 revolutions per minute and workrates of 80 W and 100 W while kinematics (240 Hz) and pedal reaction forces using a pair of instrumented pedals (1200 Hz) were collected. A 2x2 (limb × workrate) repeated measures ANOVA was run with an alpha of 0.05. Peak knee extension moment (KEM, p = 0.034) and vertical pedal reaction force (p = 0.038) were significantly reduced in the replaced limbs compared to non-replaced limbs by 21.3% and 5.3%, respectively. Peak KEM did not change for TKA patients with the increased workrate (p = 0.750). However, both peak hip extension moment (p = 0.009) and ankle plantarflexion moment (p = 0.017) increased due to increased workrate. Patients following TKA showed similar decreases in peak KEM and vertical pedal reaction force in their replaced compared to non-replaced limbs, as previously seen in gait. Patients of TKA may rely on their hip and ankle extensors to increases in workrate. Increasing intensity by 20 W did not exacerbate any inter-limb differences for peak KEM and vertical PRF.

Effects of Increased Step-Width on Knee Biomechanics During Inclined and Declined Walking.

The purpose of this study was to investigate effects of preferred step width and increased step width modification on knee biomechanics of obese and healthy-weight participants during incline and decline walking. Seven healthy-weight participants and 6 participants who are obese (body mass index ≥ 30) performed 5 walking trials on level ground and a 10° inclined and declined instrumented ramp system at both preferred and wide step-widths. A 2 × 2 (step-width × group) mixed-model analysis of variance was used to examine selected variables. There were significant increases in step-width between the preferred and wide step-width conditions for all 3 walking conditions (all P < .001). An interaction was found for peak knee extension moment (P = .048) and internal knee abduction moment (KAM) (P = .025) in uphill walking. During downhill walking, there were no interaction effects. As step-width increased, KAM was reduced (P = .007). In level walking, there were no interaction effects for peak medial ground reaction force and KAM (P = .007). There was a step-width main effect for KAM (P = .007). As step-width increased, peak medial ground reaction force and peak knee extension moment increased, while KAM decreased for both healthy weight and individuals who are obese. The results suggest that increasing step-width may be a useful strategy for reducing KAM in healthy and young populations.

Increased Q-Factor increases frontal-plane knee joint loading in stationary cycling.

BACKGROUND: Q-Factor (QF), or the inter-pedal width, in cycling is similar to step-width in gait. Although increased step-width has been shown to reduce peak knee abduction moment (KAbM), no studies have examined the biomechanical effects of increased QF in cycling at different workrates in healthy participants. METHODS: A total of 16 healthy participants (8 males, 8 females, age: 22.4 ± 2.6 years, body mass index: 22.78 ± 1.43 kg/m2, mean ± SD) participated. A motion capture system and customized instrumented pedals were used to collect 3-dimensional kinematic (240 Hz) and pedal reaction force (PRF) (1200 Hz) data in 12 testing conditions: 4 QF conditions-Q1 (15.0 cm), Q2 (19.2 cm), Q3 (23.4 cm), and Q4 (27.6 cm)-under 3 workrate conditions-80 watts (W), 120 W, and 160 W. A 3 × 4 (QF × workrate) repeated measures of analysis of variance were performed to analyze differences among conditions (p < 0.05). RESULTS: Increased QF increased peak KAbM by 47%, 56%, and 56% from Q1 to Q4 at each respective workrate. Mediolateral PRF increased from Q1 to Q4 at each respective workrate. Frontal-plane knee angle and range of motion decreased with increased QF. No changes were observed for peak vertical PRF, knee extension moment, sagittal plane peak knee joint angles, or range of motion. CONCLUSION: Increased QF increased peak KAbM, suggesting increased medial compartment loading of the knee. QF modulation may influence frontal-plane joint loading when using stationary cycling for exercise or rehabilitation purposes.