[Role of cholestanol in the pathogenesis of cholesterol cholelithiasis]. / Rol' kholestanola v patogeneze kholesterinovogo kholelitiaza.

The proportion of cholestanol/cholesterol in hepatic and cystic bile was evaluated using capillary gas-chromatography in subjects with disturbances in the biliary system (biliary dyskinesia, chronic acalculous cholecystitis, chronic calculous cholecystitis). The proportion was also measured in bile "paste" and cholesterol choleliths. With progression of cholesterol cholelithiasis, the proportion cholestanol/cholesterol increases, reaching its maximum in the stone the center of which accumulates crystals of cholestanol-cholesterol dihydrate. An original conception is proposed on pathogenesis of cholesterol cholelithiasis in man. It considers cholestanol as factor-reason underlying various pathological processes running in cholesterol cholelithiasis. Cholestanol is suggested to mark cholesterol cholelithiasis.

[The physicochemical evaluation of the bile using infrared spectroscopy]. / Fiziko-khimicheskaia otsenka zhelchi s pomoshch'iu infrakrasnoi spektroskopii.

Native bile, inspissated bile, and cholesterol choleliths were examined by infrared spectroscopy. Model compounds spectra were compared with native bile spectra. The spectra were divided into 3 groups: with acid fragments or cholesterol groups predominating and intermediate group. The peak of 3620 cm-1, absent in normal human bile and liable to augment if acid fragment level reduced was detected. The authors suggest a technique of infrared spectroscopy permitting early detection of disordered physicochemical characteristics of the bile in the course of cholesterol cholelithiasis development.

[Gas-chromatographic analysis of hypercholestanol in the bile and its role in the pathogenesis of cholelithiasis]. / Gazozhidkostno-khromatograficheskoe opredelenie giperkholestanol- kholii i ee znacheniev patogeneze kholelitiaza.

The cholestanol/cholesterol ratio in the bladder and liver bile was estimated by capillary gas-liquid chromatography in patients with dyskinesia of the gallbladder, chronic acalculous cholecystitis, and chronic calculous cholecystitis. Cholesterol biliary calculi and their surface and intermediate layers and the core were examined either. The authors came to a conclusion that cholestanol/cholesterol ratio in the bladder and liver bile reflected the progress of liver cholesterol metabolism starting from the early stages of cholelithiasis to the formation of cholesterol biliary calculi. Therefore hypercholestanolcholia should be considered as an indicator of the risk of cholesterol biliary calculi development.