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Gan To Kagaku Ryoho ; 38(10): 1709-11, 2011 Oct.
Artigo em Japonês | MEDLINE | ID: mdl-21996973

RESUMO

We report a case of synchronous multiple liver metastases of rectal cancer successfully treated with tegafur/uracil(UFT) and oral Leucovorin (LV) chemotherapy. Lower anterior resection was carried out on the rectal cancer patient (an 80-year- old man), who had synchronous multiple liver metastases. The UFT (450 mg/day) and oral LV (75 mg/day) were orally administered for 4 weeks, followed by a 1-week interval after the surgical procedure. After completion of 16 courses, CT scan showed no liver metastases, and the patient was judged to have achieved a complete response (CR). The interval of CR was maintained for sixteen months until the age of 82. This chemotherapy is expected to have a potent therapeutic efficacy for older adult patients with advanced rectal cancer, because it is convenient and causes no severe diverse events.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Leucovorina/uso terapêutico , Neoplasias Hepáticas/tratamento farmacológico , Neoplasias Retais/tratamento farmacológico , Administração Oral , Idoso , Idoso de 80 Anos ou mais , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Terapia Combinada , Humanos , Leucovorina/administração & dosagem , Neoplasias Hepáticas/secundário , Masculino , Neoplasias Retais/patologia , Neoplasias Retais/cirurgia , Tegafur/administração & dosagem , Tegafur/uso terapêutico , Tomografia Computadorizada por Raios X , Uracila/administração & dosagem , Uracila/uso terapêutico
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