RESUMO
Histone deacetylases 3 (HDAC3) is a member of the histone deacetylases family. This family is associated with cellular physiological function, such as signal transduction, cell cycle, proliferation, apoptosis, and cardiac development. HDAC3 plays an important role in the progression of malignant tumors, especially in terms of proliferation, apoptosis, metastasis, angiogenesis, and anticancer drug resistance. This review discusses the basic elements of HDAC3 and the relationship between HDAC3 and malignant tumors.
Assuntos
Regulação Neoplásica da Expressão Gênica , Histona Desacetilases/fisiologia , Neoplasias/fisiopatologia , Animais , Apoptose , Proliferação de Células , Resistência a Múltiplos Medicamentos , Humanos , Metástase Neoplásica , Transdução de Sinais , Fator A de Crescimento do Endotélio Vascular/metabolismoRESUMO
A salt-tolerant wheat cultivar (DK961) and a salt-sensitive one (LM15) were exposed to 200 mmol/L NaCl for 3 d to study selectivity in transport of K(+) and Na(+) of the leaf sheath. Na(+) content of leaf sheath and K(+) content of leaf blade of DK961 were significantly higher than those of LM15, which led to a lower Na(+)/K(+) ratio of leaf blade of DK961 than that of LM15. These results suggested that leaf sheath of DK961 had much stronger abilities of limiting Na(+) transport and allowing K(+) transport from leaf sheath to leaf blade than that of LM15 to maintain lower Na(+)/K(+) ratio of leaf blade under NaCl stress, indicating that leaf sheath may play an important role in wheat salt tolerance.
