Fluoroscopically guided vascular and cardiac transcatheter procedures: a comparison of occupational and patient dose by anatomical region.

X-ray guided procedures are being performed by an increasing variety of medical specialties. Due to improvements in vascular transcatheter therapies, there is an increasing overlap of imaged anatomy between medical specialties. There is concern that non-radiology fluoroscopic operators may not have sufficient training to be well informed of the potential implications of radiation exposure and mitigation strategies to reduce dose. This was a prospective, observational, single center study to compare occupational and patient dose levels when imaging different anatomical regions during fluoroscopically guided cardiac and endovascular procedures. Occupational radiation dose was measured at the level of the temple of 24 cardiologists and 3 vascular surgeons (n = 1369), 32 scrub nurses (n = 1307) and 35 circulating nurses (n = 885). The patient dose was recorded for procedures (n = 1792) performed in three angiography suites. Abdominal imaging during endovascular aneurysm repair (EVAR) procedures was associated with a comparatively high average patient, operator and scrub nurse dose despite additional table-mounted lead shields. Air kerma was relatively high for procedures performed in the chest, and chest + pelvis. Higher dose area product and staff eye dose were recorded during procedures of the chest + pelvis due to the use of digital subtraction angiography to evaluate access route prior to/during transaortic valve implantation. Scrub nurses were exposed to higher average radiation levels than the operator during some procedures. Staff should be cognizant of the potentially higher radiation burden to patients and exposed personnel during EVAR procedures and cardiac procedures using digital subtraction angiography.

A comparison of patient dose and occupational eye dose to the operator and nursing staff during transcatheter cardiac and endovascular procedures.

The number and complexity of transcatheter procedures continue to increase, raising concerns regarding radiation exposure to patients and staff. Procedures such as transaortic valve implantations (TAVI) have led to cardiologists adopting higher dose techniques, such as digital subtraction angiography (DSA). This study compared the estimated patient and occupational eye dose during coronary angiography (CA), percutaneous coronary intervention (PCI), TAVI workups (TWU), TAVI, endovascular aneurysm repairs (EVAR), and other peripheral diagnostic (VD) and interventional (VI) vascular procedures. A quantitative analysis was performed on patient dose during 299 endovascular and 1498 cardiac procedures. Occupational dose was measured for the cardiologists (n = 24), vascular surgeons (n = 3), scrub (n = 32) and circulator nurses (n = 35). TAVI and EVAR were associated with the highest average dose for all staff, and significantly higher patient dose area product, probably attributable to the use of DSA. Scrub nurses were exposed to higher average doses than the operator and scout nurse during CA, VD and VI. Circulating nurses had the highest average levels of exposure during TAVI. This study has demonstrated that EVAR and TAVI have similar levels of occupational and patient dose, with a notable increase in circulator dose during TAVI. The use of DSA during cardiac procedures is associated with an increase in patient and staff dose, and cardiologists should evaluate whether DSA is necessary. Scrub nurses may be exposed to higher levels of occupational dose than the operator.

A publicly available dataset of out-of-field dose profiles of a 6 MV linear accelerator.

An increase in radiotherapy-induced secondary malignancies has led to recent developments in analytical modelling of out-of-field dose. These models must be validated against measurements, but currently available datasets are outdated or limited in scope. This study aimed to address these shortcomings by producing a large dataset of out-of-field dose profiles measured with modern equipment. A novel method was developed with the intention of allowing physicists in all clinics to perform these measurements themselves using commonly available dosimetry equipment. A standard 3D scanning water tank was used to collect 36 extended profiles. Each profile was measured in two sections, with the inner section measured with the beam directly incident on the tank, and the outer section with the beam incident on a water-equivalent phantom abutted next to the tank. The two sections were then stitched using a novel feature-matching approach. The profiles were compared against linac commissioning data and manually inspected for discontinuities in the overlap region. The dataset is presented as a publicly accessible comma separated variable file containing off-axis ratios at a range of off-axis distances. This dataset may be applied to the development and validation of analytical models of out-of-field dose. Additionally, it may be used to inform dose estimates to radiosensitive implants and anatomy. Physicists are encouraged to perform these out-of-field measurements in their own clinics and share their results with the community.

Impact of dose reducing software on patient and staff temple dose during fluoroscopically guided pacemaker insertion, closure devices implantation and coronary angiography procedures.

The aim of this study is to investigate the effectiveness of dose reducing software (ClarityIQ) on patient and staff dose during fluoroscopically guided cardiac procedures. Dose measurements were collected in a room without dose reducing software (n = 157) and compared with similar procedures performed in two rooms with the software (n = 1141). Procedures included diagnostic coronary angiography, percutaneous coronary intervention, deployment of cardiac closure devices (for occlusion of atrial septal defect, patent foramen ovale, and atrial appendage) and insertion of permanent pacemakers. The dose reducing software was found to be effective in reducing patient and staff dose by approximately 50%. This study has added to the limited literature reporting on the capability of dose reducing software to decrease radiation exposure during the implantation of cardiac closure devices, as well as demonstrating a reduction in dose to the cardiologist and nursing staff. Administrators should ensure timely upgrades to angiographic equipment to safeguard patients and staff against the potentially adverse effects of radiation exposure. Regardless of the use of dose reducing software, the mean occupational dose during closure devices was in descending order scout > scrub > cardiologist. Scrub nurse dose was found to be higher than the cardiologist during closure devices (0.98/0.26 µSv) and diagnostic coronary angiograms (1.51/0.82 µSv). Nursing staff should be aware that their levels of radiation dose during some cardiac procedures may come close to or even exceed that of the cardiologist.

Radiation dose to nurses, cardiologists, and patients during coronary angiography: a comparison of femoral and radial access.

BACKGROUND: Exposure to radiation during fluoroscopically guided cardiac procedures is a cause for concern for both the patient and staff. AIMS: This study sought to compare the occupational and patient radiation dose during femoral and radially accessed invasive coronary angiography (CA). METHODS AND RESULTS: Occupational dose (µSv) was measured at the left temple of the cardiologist (n = 17), scrub (n = 27), and circulator nurse (n = 27) during 761 femoral and 671 radially accessed diagnostic coronary angiograms and percutaneous coronary intervention (PCI) procedures. Patient dose parameters of dose area product (DAP) (Gy.cm2) and air kerma (AK) (Gy) were also measured. Coronary angiography performed via the radial artery is associated with greater mean dose to the cardiologist, with the exception of procedures including only PCI. Results demonstrated that scrub nurses are exposed to higher mean doses than the cardiologist when using femoral access and similar doses during radial cases. Both AK and DAP were associated with a higher average dose for femoral PCI than radial, with DAP being significantly higher. CONCLUSIONS: Awareness of factors that increase the dose to staff and patients is vital to inform and improve practice. This study has demonstrated that access route during diagnostic CA and PCI influences both patient and staff dose. Radiation dose to in-room staff other than the fluoroscopic operator should be a focus of future research. In addition, all staff present during X-ray guided procedures should be provided with radiation education and adopt dose minimization strategies to reduce occupational exposures.

Comparison of patient and staff temple dose during fluoroscopically guided coronary angiography, implantable cardiac devices, and electrophysiology procedures.

There is a paucity of literature comparing patient and staff dose during coronary angiography (CA), implantable cardiac devices, permanent pacemakers (PPM) and electrophysiology (EP) procedures and little noting dose to staff other than cardiologists. This study sought to compare patient and occupational dose during a range of fluoroscopically guided cardiac procedures. Radiation dose levels for the patients (n = 1651), cardiologists (n = 24), scrub (n = 32) and scout nurses (n = 35) were measured in a prospective single-centre study between February 2017 and August 2019. A comparison of dose during CA, device implantation, PPM insertion and EP studies was performed. Three angiographic units were used, with dosimeters worn on the temple of staff. Results indicated that occupational dose during PPM was significantly higher than other procedures. The cardiologist had the highest mean dose during biventricular implantable cardioverter-defibrillators; levels were approximately five times that of 'normal' pacemaker insertions. Transcatheter aortic valve implantations (TAVI) were associated with relatively high mean doses for both staff and patients and had a statistically significant higher (>2 times) mean patient dose area product than all other categories. TAVI workups were also related to higher mean cardiologist and scrub nurse dose. It was observed that the mean scrub nurse dose can exceed that of the cardiologist. The highest mean dose for Scout nurses were recorded during EP studies. Given the significantly higher temple dose associated with PPM insertion, cardiologists should consider utilizing ceiling mounted lead shields, lead glasses and/or skull caps where possible. Efforts should also be made to minimize the use of DSA during TAVI and TAVI workups to reduce cardiologist, nurse and patient dose.

Occupational and Patient Radiation Dose and Quality Implications of Femoral Access Imaging During Coronary Angiography.

PURPOSE: Cardiologists often perform angiography of the common femoral artery (CFA) access site to evaluate whether the anatomy is suitable for deployment of a vascular closure device or to assess whether iatrogenic vessel damage has occurred. The choice of acquisition mode has radiation dose implications. The objective of this study was to investigate the influence of the selected type of CFA x-ray imaging mode (fluoro save, cine acquisition and digital subtraction angiography (DSA)) and tube angle on patient and staff dose during coronary angiography. MATERIALS AND METHODS: Assessment of image quality for the different modes was performed to determine whether lower dose modes provide images of sufficient clinical quality to be routinely employed. Radiation dose levels for the patients (n=782), cardiologists (n=17), scrub nurses (n=27) and scout nurses (n=32) were measured in a prospective single-centre study between February 2017 and August 2019. Three Philips angiographic units and DoseAware dose monitoring systems were used. RESULTS: Among the acquisition modes, fluoro save provided acceptable diagnostic quality for visualizing femoral access points and diagnosing pathology in 99% of cases. Average patient dose area product (DAP) was 83.95, 742.50, and 3363.41mGy2 and average patient air kerma (AK) was 0.87, 8.44, and 18.61mGy for fluoro save, cine, and DSA acquisitions, respectively. The use of higher dose imaging modes, imaging in the contralateral view and utilizing steeper TA was associated with a higher patient dose. Due to staff dose being highly correlated with DAP and AK, it was difficult to observe any association between staff dose and CFA imaging mode. However, this does not discount a potential increase in occupational dose due to the use of cine angiography or digital subtraction angiography during CFA imaging. CONCLUSION: DSA of the CFA should be avoided during transfemoral coronary angiography unless critical to diagnostic analysis. It is recommended that fluoroscopic operators consider utilizing lower dose modes in the ipsilateral orientation ≤32° TA to reduce the risk of patient and staff radiation exposure.

Dosimetric evaluation of a patient-specific 3D-printed oral positioning stent for head-and-neck radiotherapy.

As head-and-neck radiotherapy treatments become more complex and sophisticated, and the need to control and stabilise the positioning of intra-oral anatomy becomes more important, leading the increasing use of oral positioning stents during head-and-neck radiotherapy simulation and delivery. As an alternative to the established practice of creating oral positioning stents using wax, this study investigated the use of a 3D printing technique. An Ender 5 3D printer (Creality 3D, Shenzhen, China) was used, with PLA+ "food-safe" polylactic acid filament (3D Fillies, Dandenong South, Australia), to produce a low-density 3D printed duplicate of a conventional wax stent. The physical and dosimetric effects of the two stents were evaluated using radiochromic film in a solid head phantom that was modified to include flexible parts. The Varian Eclipse treatment planning system (Varian Medical Systems, Palo Alto, USA) was used to calculate the dose from two different head-and-neck treatment plans for the phantom with each of the two stents. Examination of the resulting four dose distributions showed that both stents effectively pushed sensitive oral tissues away from the treatment targets, even though most of the phantom was solid. Film measurements confirmed the accuracy of the dose calculations from the treatment planning system, despite the steep density gradients in the treated volume, and demonstrated that the 3D print could be a suitable replacement for the wax stent. This study demonstrated a useful method for dosimetrically testing novel oral positioning stents. We recommend the development of flexible phantoms for future studies.

Measuring foetal dose from tomotherapy treatments.

INTRODUCTION: Treating pregnant women in the radiotherapy clinic is a rare occurrence. When it does occur, it is vital that the dose received by the developing embryo or foetus is understood as fully as possible. This study presents the first investigation of foetal doses delivered during helical tomotherapy treatments. Six treatment plans were delivered to an anthropomorphic phantom using a tomotherapy machine. These included treatments of the brain, unilateral and bilateral head-and-neck, chest wall, and upper lung. Measurements of foetal dose were made with an ionisation chamber positioned at various locations longitudinally within the phantom to simulate a variety of patient anatomies. All measurements were below the established limit of 100 mGy for a high risk of damage during the first trimester. The largest dose encountered was 75 mGy (0.125% of prescription dose). The majority of treatments with measurement positions less than 30 cm fell into the range of uncertain risk (50 - 100 mGy). All treatments with measurement positions beyond 30 cm fell into the low risk category (< 50 mGy). For the cases in this study, tomotherapy resulted in foetal doses that are at least on par with, if not significantly lower than, similar 3D conformal or intensity-modulated treatments delivered with other devices. Recommendations were also provided for estimating foetal doses from tomotherapy plans.

Comparison of global and local gamma evaluation results using isodose levels.

The aim of this study is to evaluate the behaviour of global and local gamma analyses with isodose levels. Global and local gamma evaluation were performed on patient-specific quality assurance (PSQA) data from 100 volumetric modulated arc therapy (VMAT) arcs and 100 helical tomotherapy (HT) plans, using an in-house gamma code. Gamma pass rates versus isodose levels were plotted and evaluated. Other than a slightly increased skew towards higher pass rates for the global gamma evaluation, minimal differences were observed between the results of evaluating all VMAT arcs separately and the results of evaluating over VMAT treatment plans by combining arcs from each plan. Generally, the VMAT results showed average pass rates that increase with decreasing isodose level, for both global and local gamma evaluations. The HT results differed systematically from the VMAT results, with the results of performing global and local gamma evaluations agreeing more closely at all isodose levels and with the highest gamma pass rates being achieved at intermediate dose levels, between the 40 and 70% isodose levels. These results demonstrate the complex of relationships between global and local gamma evaluation results that can arise when clinical PSQA data are analysed and exemplify how the local gamma evaluation does not necessarily produce disproportionately reduced gamma pass rates in low dose regions. Performing gamma evaluation with different isodose levels is suggested as a useful method to improve understanding of specific PSQA data and as well as the broader features of gamma evaluation results.

Taller staff occupationally exposed to less radiation to the temple in cardiac procedures, but risk higher doses during vascular cases.

This study aimed to evaluate the effect of nurse and doctor height on occupational dose to the temple during fluoroscopically guided cardiovascular procedures. Additionally, an evaluation of the relationship between doctor height and table height was performed. Staff exposed during fluoroscopic procedures may be at elevated risk of cardiovascular damage or oncogenesis and have demonstrated a higher incidence of subscapular cataracts. The heads of taller staff may be exposed to reduced levels of radiation due to the increased distance from the area of highest intensity X-ray scatter. Limited research has been performed investigating height as a predictor of head dose to nursing staff. The level of radiation dose at the level of the temple to the doctor (n = 25), scrub (n = 28), and scout nurse (n = 29) was measured in a prospective single-center, observational study using Philips DoseAware badges. Procedural characteristics were recorded for vascular and cardiac cases performed in three dedicated angiography suites. Data were also collected to investigate relationships between doctor height and table height. Data were collected for 1585 cardiac and 294 vascular procedures. Staff height was a statistically significant predictor of temple dose for doctors, scrub, and scout nurses when considering the full data sample. The log temple dose demonstrated an inverse relationship to staff height during cardiac procedures, but a positive relationship for scrub and scout nurses during vascular studies. This observational study has demonstrated that taller staff are exposed to less cranial exposure dose during fluoroscopically guided cardiac examinations but has revealed a positive correlation between height and temple dose during vascular procedures. It was also determined that doctor height was correlated with average procedural table height and that vascular access point influences the choice of table elevation.

Exploring the gamma surface: A new method for visualising modulated radiotherapy quality assurance results.

PURPOSE: This work presents a novel method of visualising the results of patient-specific quality assurance (QA) for modulated radiotherapy treatment plans, using a three-dimensional distribution of gamma pass rates, referred to as the "gamma surface". The method was developed to aid in comparing borderline and failing QA plans, and to better compare patient-specific QA results between departments. METHODS: Gamma surface plots were created for a representative sample of situations encountered during patient-specific QA. To produce a gamma surface plot, for each QA result, gamma pass rates were plotted as a heat map, with dose difference on one axis and distance-to-agreement on the other. This involved the calculation of 100 × 100 gamma pass rates over a dose difference and distance-to-agreement grid. As examples, five 220 × 680 arrays of dose points from radiotherapy treatment plans were compared against measurement data consisting of 21 × 66 arrays of dose points spaced 10 mm apart. RESULTS: The gamma surface plots facilitated the rapid evaluation of criteria combinations for each plan, clearly highlighting the difference between plans that are modelled and delivered well, and those that are not. Large scale features were also evident in each surface, hinting at potential over-modulation, systematic dose errors, and small or large scale areas of disagreement in the distributions. CONCLUSIONS: Gamma surface plots are a useful tool for investigating QA failures and borderline results, and have the capacity to grant insights into treatment plan QA performance that may otherwise be missed.

The new Scopus CiteScore formula and the Journal Impact Factor: a look at top ranking journals and middle ranking journals in the Scopus categories of General Physics and Astronomy, Materials Science, General Medicine and Social Sciences.

In June 2020 Elsevier announced that the CiteScore metric of journals underwent a change. This work examines the effect of these changes for 40 journals, chosen from the top five and middle five (ranked by CiteScore) journals in the subject areas of General Physics and Astronomy, Materials Science, Medicine, Social Sciences) and compares to the Journal Impact Factor. It is shown that in the data studied here, the new methodology is less susceptible to influence of the proportion of editorial material in a journal, but tends to favour journals in research fields that publish articles which get cited more quickly.

Characteristics of inverse gamma histograms.

This work explores the characteristics of the inverse gamma histogram and its potential use as part of the patient specific quality assurance (PSQA) program for volumetric modulated arc therapy (VMAT). ArcCheck measured dose files and TPS predicted dose files were imported and analysed using the in-house inverse gamma code developed in the Python package. Inverse gamma with fixed distance-to-agreement of 2 mm were calculated for 23 VMAT arcs. Dose difference histograms were plotted for six arbitrarily selected arcs with the 95th and 90th percentile values calculated. Dose difference histograms enabled visualisation of the dose difference distribution information. The 95th and 90th percentile values are equivalent to the dose difference criteria where the gamma pass rate is 95% and 90% respectively. These values can be used as a guide to assess plan acceptability, especially for plans that failed the initial gamma evaluation. The inverse gamma histograms are demonstrated to be a useful tool for plan evaluation in addition to the traditional gamma evaluation method. It contains dose difference or distance-to-agreement distribution information, which could be clinically useful for plan evaluation.

Investigating the use of aperture shape controller in VMAT treatment deliveries.

BACKGROUND: Aperture shape controller (ASC) is a recently introduced leaf sequencer that controls the complexity of multileaf collimator apertures in the Photon Optimizer algorithm of the Eclipse treatment planning system. The aim of this study is to determine if the ASC can reduce plan complexity and improve verification results, without compromising plan quality. METHODS: Thirteen plans grouped into cohorts of head and neck/brain, breast/chest and pelvis were reoptimised using the same optimization as the non-ASC setting for low, moderate and high ASC settings. These plans were analyzed using plan quality indices such as the conformity index and homogeneity index in addition to dose-volume histogram based analysis on PTVs and organ at risks. Complexity assessments were performed using metrics such as average leaf pair opening, modulation complexity scores, relative monitor units (MU) and treatment time. Monitor unit per gantry angle variations were also analyzed. A third-party algorithm was also used to assess 3D dose distributions produced using the new leaf sequencer tool. Deliverability for the final multileaf collimator distribution was quantified using portal dose image prediction based gamma analysis. RESULTS: Plan conformality assessments showed comparable results and no significant plan degradation for plans reoptimised using ASC. Reduction in overall MU distributions were seen in some cases using higher ASC however, no overall trends were observed. In general, treatment deliverability, assessed using gamma analysis did not improve drastically however MU per degree distribution in 1 case improved when reoptimised using ASC. Treatment MUs generally reduced when ASC settings were used whilst in 1 case an increase in the treatment time factor > 1.8 was observed. The third-party algorithm assessment showed an underestimation of dose calculations for all cohorts used in this study when a higher ASC setting is used. CONCLUSIONS: The impact of using ASC in treatment plans was characterised in this study. Although plan complexity marginally improved when using higher ASC settings, no consensus could be reached based on metrics analyzed in this study. A reduction in MU distribution was observed with increasing ASC settings in most cases. This study recommends that ASC to be used as an additional tool only to test its suitability to reduce plan complexity.

Departmental action limits for TQA energy variations defined by means of statistical process control methods.

The purpose of this study is to define departmental action limits for energy percentage variation measured by means of step-wedge helical Tomotherapy quality assurance module. Individual charts using the Statistical Process Control techniques have been used to identify retrospectively out-of-control situations ascribable to documented actions performed on the Tomotherapy system. Using the in-control data of our analysis process capability indices (cp, cpk, cpm and cpmk) are calculated in order to document the real working condition of the Tomotherapy system. Our findings indicate use of an action limit of 1.0% for energy percentage variation difference between the measured and reference output is a good working condition of a Tomotherapy system. cp and cpk indices are suggested as good indices that correctly report the system capability. A method for calculating and reporting Tomotherapy action limits for the integrated self-checking TQA energy check was shown in this study. SPC technique has proven to be efficient in defining departmental action limits from retrospective data for TQA energy measurements, hence optimally enabling corrective improvements in the process of quality assurance.

A multi-institutional evaluation of machine performance check system on treatment beam output and symmetry using statistical process control.

BACKGROUND: The automated and integrated machine performance check (MPC) tool was verified against independent detectors to evaluate its beam uniformity and output detection abilities to consider it suitable for daily quality assurance (QA). METHODS: Measurements were carried out on six linear accelerators (each located at six individual sites) using clinically available photon and electron energies for a period up to 12 months (n = 350). Daily constancy checks on beam symmetry and output were compared against independent devices such as the SNC Daily QA 3, PTW Farmer ionization chamber, and SNC field size QA phantom. MPC uniformity detection of beam symmetry adjustments was also assessed. Sensitivity of symmetry and output measurements were assessed using statistical process control (SPC) methods to derive tolerances for daily machine QA and baseline resets to account for drifts in output readings. I-charts were used to evaluate systematic and nonsystematic trends to improve error detection capabilities based on calculated upper and lower control levels (UCL/LCL) derived using standard deviations from the mean dataset. RESULTS: This study investigated the vendor's method of uniformity detection. Calculated mean uniformity variations were within ± 0.5% of Daily QA 3 vertical symmetry measurements. Mean MPC output variations were within ± 1.5% of Daily QA 3 and ±0.5% of Farmer ionization chamber detected variations. SPC calculated UCL values were a measure of change observed in the output detected for both MPC and Daily QA 3. CONCLUSIONS: Machine performance check was verified as a daily quality assurance tool to check machine output and symmetry while assessing against an independent detector on a weekly basis. MPC output detection can be improved by regular SPC-based trend analysis to measure drifts in the inherent device and control systematic and random variations thereby increasing confidence in its capabilities as a QA device. A 3-monthly MPC calibration assessment was recommended based on SPC capability and acceptability calculations.

A method for obtaining three-dimensional measurements of HDR brachytherapy dose distributions using Fricke gel dosimeters and optical computed tomography.

This study aimed to develop a method for performing accurate, high-resolution, three-dimensional (3D) Fricke gel dosimetry measurements of high dose rate (HDR) brachytherapy dose distributions using optical computed tomography (CT). A multi-needle brachytherapy gel phantom was purpose-built to contain four stainless-steel brachytherapy needles and a sample of Fricke Xylenol gel. A Paris-style HDR brachytherapy treatment was planned and delivered to the gel, which was then read out using a novel optical CT scanning method; all the brachytherapy needles were removed prior to scanning and replaced with a refractive index matched fluid. The removal of the stainless-steel needles during pre- and post-irradiation scanning minimised the potential for artefacts caused by missing ray-sum data. Results showed good agreement between measured and calculated doses (within 1%) at all positions greater than 0.1 cm from each needle. This study demonstrated that 3D Fricke gel phantoms may be valuable tools in verifying HDR brachytherapy treatments. The phantom construction and optical CT scanning method proposed in this work has the potential to enable routine quality assurance measurements of complex HDR brachytherapy treatment deliveries via accurate and detailed three-dimensional dose measurements.