RESUMO
INTRODUCTION: Adenopathies are a frequent cause of recourse in internal medicine. When histological analysis reveals the presence of granuloma, multiple infectious or non-infectious etiologies are considered. If diagnoses of lymphoma, sarcoidosis or tuberculosis are easily mentioned, tularemia should also be considered in the differential diagnosis. OBSERVATION: A 54-year-old patient had a fever at the evening with night sweats and a cough resistant to two lines of antibiotics. A thoraco-abdomino-pelvic CT scan revealed hilar and mediastinal adenopathies that appeared hypermetabolic with PET-TDM, as well as pulmonary nodules. A PCR performed on lymph node biopsy and serology allowed the diagnosis of tularemia. The evolution was favourable after antibiotic treatment. CONCLUSION: The association of fever, night sweats, altered general state and mediastinal adenopathies should be considered as a diagnosis of tularemia. Ganglionic biopsy, combined with molecular biology techniques and serology, can confirm the diagnosis.
Assuntos
Linfoma/diagnóstico , Tularemia/diagnóstico , Antibacterianos/uso terapêutico , Ciprofloxacina/uso terapêutico , Diagnóstico Diferencial , Feminino , Granuloma/diagnóstico , Granuloma/tratamento farmacológico , Granuloma/microbiologia , Humanos , Linfadenite/diagnóstico , Linfadenite/tratamento farmacológico , Linfadenite/microbiologia , Pessoa de Meia-Idade , Tularemia/complicações , Tularemia/tratamento farmacológicoRESUMO
The decision to order component blood products is perhaps the most critical step in patient's transfusion safety. A variety of techniques used to bring about behavioural changes in the transfusion practices of physicians have been met with limited success. Computerized order entry (CPOE) and decision support systems have been demonstrated to improve the quality of orders in terms of legibility and completeness. In addition, CPOE systems have been shown to affect physician ordering behaviour and to reduce the percentage of inappropriate orders. However, CPOE systems with poorly interfaced designs can result in usability problems and finally in order errors. Evaluation of the system has to guide CPOE systems' evolutions to aid in patient safety.
Assuntos
Bancos de Sangue/normas , Segurança do Sangue , Sistemas Computacionais , França , HumanosRESUMO
A case is reported of a 40-year-old woman presenting with cerebral malaria complicated by an adult respiratory distress syndrome (ARDS). The patient was admitted to the intensive care unit in a coma, scored 5 on the Glasgow scale. Plasmodium falciparum parasitaemia was, at the time, 50%. A continuous intravenous quinine infusion (25 mg.kg-1.day-1) was started, together with the required symptomatic treatment. Blood was transfused because of increasing anaemia (haemoglobin 60 g.l-1). After 24 h, parasitaemia was 12%, consumption of clotting factors broke out (prothrombine 43%, fibrin degradation products greater than 40 micrograms.ml-1, platelets 45 G.l-1). Hypoxaemia (PaO2 = 46 mmHg) and hypocapnia (PaCO2 = 32 mmHg) became obvious, together with bilateral diffuse alveolar infiltrates on chest X-ray. Haemodynamic data suggested non cardiogenic oedema: PEEP 20 cm H2O, cardiac output 6.15 l.min-1, mean pulmonary arterial pressure 35 mmHg, pulmonary wedged pressure 15 mmHg. The hypoxia worsened and the patient died on the 15th day after associated with high levels of parasitaemia. Several reports have suggested that it may be related to increased capillary permeability. Initial fluid overload should therefore be avoided. Parenteral quinine remains the mainstay of treatment, because of its rapid schizonticidal activity. Although exchange transfusion seems to be a valuable adjunct to chemotherapy, it requires further assessment.