RESUMO
The composition of the laboratory-prepared essential oils from Uruguayan Nova and Satsuma mandarins has been studied. The volatile fraction was analyzed by HRGC and HRGC/MS (quadrupole); 79 and 73 components were identified in Nova and Satsuma mandarin oils, respectively. The linear retention indices were calculated for almost all identified components on two different stationary phases. The enantiomeric distribution of beta-pinene, sabinene, limonene, linalool, and alpha-terpineol was studied by multidimensional gaschromatography (MDGC). Polymethoxylated flavones, present in the nonvolatile residue, were analyzed by normal-phase HPLC.
Assuntos
Óleos Voláteis/química , Cromatografia Gasosa , Estereoisomerismo , UruguaiRESUMO
Wild, pigmented strains of Serratia marcescens and their non-pigmented mutants were compared on the basis of fatty acid profiles and lipid content. Classic biochemical tests show only minor differences, as well as fatty acid ratio C18:C16. The total amount of lipid synthesized and the saturated/unsaturated fatty acids ratio disclose a sharp total lipid reduction and a high percentage of unsaturated fatty acids in the pigmented strains, placing them in separated clusters compared with the nonpigmented mutants. It is hypothesized that the synthesis of the polyacetate required for the completion of the prodigiosin molecule may result in waste of methyl groups and thus affect the total amount of lipids.
Assuntos
Ácidos Graxos/análise , Pigmentos Biológicos/biossíntese , Prodigiosina/biossíntese , Serratia marcescens/metabolismo , Cromatografia Gasosa , Serratia marcescens/química , Espectroscopia de Infravermelho com Transformada de FourierRESUMO
A series of novel, potent and selective pyrido[1,2-a]pyrazine dopamine D4 receptor antagonists are reported including CP-293,019 (D4 Ki = 3.4 nM, D2 Ki > 3,310 nM), which also inhibits apomorphine-induced hyperlocomotion in rats after oral dosing.
Assuntos
Antagonistas de Dopamina/síntese química , Antagonistas dos Receptores de Dopamina D2 , Atividade Motora/efeitos dos fármacos , Pirazinas/síntese química , Pirimidinas/síntese química , Animais , Apomorfina/farmacologia , Antagonistas de Dopamina/química , Antagonistas de Dopamina/farmacologia , Desenho de Fármacos , Haloperidol/farmacologia , Indicadores e Reagentes , Estrutura Molecular , Pirazinas/química , Pirazinas/farmacologia , Pirimidinas/química , Pirimidinas/farmacologia , Ratos , Receptores de Dopamina D4 , Relação Estrutura-AtividadeRESUMO
An in vitro study was conducted into the speed of glycolysis is human erythrocytes. Incubation with Buflomedil does not change the speed of glycolysis.
Assuntos
Eritrócitos/metabolismo , Glicólise/efeitos dos fármacos , Pirrolidinas/farmacologia , Trifosfato de Adenosina/metabolismo , Glicemia/metabolismo , Eritrócitos/efeitos dos fármacos , HumanosRESUMO
Variations in erythrocyte ATP content were studied after the oral administration of 600 mg Buflomedil a day for seven days in ten vasculopathy patients. In all patients the drug increased erythrocyte ATP.
