RESUMO
Three stable and simple synthetic routes of labeled D9 -Mabuterol, D9 -Bambuterol, and D9 -Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope-abundance were confirmed according to 1 H NMR and liquid chromatography-tandem mass spectrometry.
Assuntos
2-Hidroxifenetilamina/análogos & derivados , Compostos de Anilina/química , Compostos de Anilina/síntese química , Clembuterol/análogos & derivados , Deutério/química , Terbutalina/análogos & derivados , 2-Hidroxifenetilamina/síntese química , 2-Hidroxifenetilamina/química , Técnicas de Química Sintética , Clembuterol/síntese química , Clembuterol/química , Marcação por Isótopo , Terbutalina/síntese química , Terbutalina/químicaRESUMO
Ruthenium-catalyzed oxidation of multisubstituted allyl alcohols in the presence of benzaldehyde gives enals or enones in good yields. Unlike the commonly reported ruthenium-catalyzed isomerization reaction of allyl alcohols to give saturated ketones, an intermolecular rather than intramolecular hydrogen transfer is involved in this transformation. This reaction offers an efficient, mild, and high-yielding method for the preparation of substituted α,ß-unsaturated compounds.