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2.
Rev Clin Esp (Barc) ; 224(4): 197-203, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38423384

RESUMO

AIM: To study the prevalence of neutralizing antibodies in healthcare workers and healthcare support personnel after the administration of the second dose of the BNT162b2 vaccine (Pfizer-BioNTech). MATERIALS AND METHODS: In December 2021, we undertook a study in the Health Department in Orihuela, Alicante (Spain), which consists of 1500 workers. We collected demographic variables about the study participants, and we performed a "point-of-care" immunochromatography test to measure the presence of neutralizing antibodies (OJABIO® SARS-CoV-2 Neutralizing Antibody Detection Kit, manufactured by Wenzhou OJA Biotechnology Co., Ltd. Wenzhou, Zhejiang, China) before the administration of the third dose of the vaccine. RESULTS: We obtained complete information about 964 (64%) workers, which consisted of 290 men and 674 women. The average age was 45,8 years (min. 18, max. 68) and the average time since the last dose of the vaccine was 40,5 weeks (min. 1,71, max. 47,71). A total of 131 participants (13,5%) had suffered infection by SARS-CoV-2 confirmed using RT-PCR. The proportion of participants who showed presence of neutralizing antibodies was 38,5%. In the multivariable analysis, the time since the last dose of the vaccine (aOR week: 1,07; 95%CI: 1,04; 1,09) and previous infection by SARS-CoV-2 (aOR: 3,7; 95CI: 2,39; 5,63) showed a statistically significant association with the presence of neutralizing antibodies. CONCLUSIONS: The time since the administration of the last dose of the vaccine and the previous infection by SARS-CoV-2 determined the presence of neutralizing antibodies in 38,5% of the healthcare workers and support workers.


Assuntos
COVID-19 , Vacinas , Masculino , Humanos , Feminino , SARS-CoV-2 , Prevalência , Espanha/epidemiologia , Vacina BNT162 , COVID-19/diagnóstico , COVID-19/epidemiologia , COVID-19/prevenção & controle , Pessoal de Saúde , Anticorpos Neutralizantes , Testes Sorológicos , Teste para COVID-19
3.
Actas Urol Esp (Engl Ed) ; 48(2): 162-169, 2024 Mar.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-37832847

RESUMO

OBJECTIVE: To analyze the level of agreement of the Post-Ureteroscopy Lesion Scale (PULS) and the consequences on its application in clinical practice with more reliable statistical data than the one used in the original work. METHODS: 14 URS and 14 micro-URS were performed in 14 female porcine model. All the procedures were video recorded and an anatomopathological analysis was performed in each ureter. Sixteen urologists (9 endourologists and 7 general urologists) and 4 residents evaluated the ureteral lesions according to the PULS, with degrees 0, 1 and ≥2. The agreement was calculated with percentages, Kendall's W coefficient and the indicators Fleiss' Kappa and Krippendorff's Alpha, while the inter-rater agreement was calculated with Spearman's correlation and Cohen's Kappa. RESULTS: The percent of agreement was 11.1%. The coefficients were likewise classified as low or very low, with the greatest agreement found among the inexperienced. Also, 50% of the raters did not agree with the rest. CONCLUSIONS: The low inter-rater agreement, the specificity of the PULS and the clinical-pathological correlation suggests that this scale is not simple, and probably has a long learning curve.


Assuntos
Ureter , Feminino , Suínos , Animais , Ureteroscopia/métodos , Reprodutibilidade dos Testes
4.
Rev Esp Quimioter ; 33(5): 313-326, 2020 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-32683837

RESUMO

OBJECTIVE: The appearance of new infectious diseases, such as COVID-19, poses a challenge in monitoring pregnancy and preventing obstetric and neonatal complications. A scoping review has the objective to review the information available in pregnant women infected with the MERS-CoV, SARSCoV, SARS-CoV-2 coronaviruses to assess the similarities in terms of and differences in the clinical characteristics of the mothers and neonatal outcomes. METHODS: We carried out a bibliographic search (scoping review) according to the PRISMA guidelines between March and April 2020 in the MEDLINE, SciELO, and CUIDEN databases and the Elsevier COVID-19 Information Center. RESULTS: We analyzed 20 articles with a total of 102 cases. 9 of MERS-CoV, 14 of SARS-CoV and 79 of SARS-CoV-2. Fever (75.5%) and pneumonia (73.5%) were the most frequent symptoms in infected pregnant women. The most frequent obstetric complications were the threat of premature delivery (23.5%) and caesarean section (74.5%). No vertical transmission was documented in any of the infants. CONCLUSIONS: All three coronaviruses produce pneumonia with very similar symptoms, being milder in the case of SARSCoV2. Despite documented obstetric complications, neonatal outcomes are mostly favorable. Increased knowledge is needed to improve and prevent obstetric and neonatal complications from these infections in pregnant women.


Assuntos
Betacoronavirus , Coronavírus da Síndrome Respiratória do Oriente Médio , Complicações Infecciosas na Gravidez , Síndrome Respiratória Aguda Grave/complicações , Coronavírus Relacionado à Síndrome Respiratória Aguda Grave , Adulto , COVID-19 , Cesárea , Infecções por Coronavirus/complicações , Infecções por Coronavirus/epidemiologia , Feminino , Febre/etiologia , Humanos , Recém-Nascido , Pandemias , Pneumonia Viral/complicações , Pneumonia Viral/epidemiologia , Pneumonia Viral/etiologia , Gravidez , Complicações Infecciosas na Gravidez/epidemiologia , Resultado da Gravidez , Nascimento Prematuro/etiologia , SARS-CoV-2 , Síndrome Respiratória Aguda Grave/epidemiologia , Avaliação de Sintomas/estatística & dados numéricos
5.
Rev Esp Quimioter ; 31(4): 344-352, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29932315

RESUMO

OBJECTIVE: To study influenza vaccination uptake in pregnant women from three Health Departments in the Valencian Community (Spain) during the 2014-15 flu season, to identify degree of knowledge, sources of information and attitudes toward immunization against influenza. METHODS: Multicentre cross-sectional descriptive study during the 2014-15 vaccination campaign. Vaccine coverage was determined using the Nominal Vaccination Registry (NVR). Subsequently, a telephone survey was carried out on a sample of vaccinated and unvaccinated postpartum women. RESULTS: The NVR had information on 934 (59.5%) out of 1,569 postpartum women; distribution per Health Departments was: 420 (44.9%), 161 (17.2%) and 353 (37.8%) in La Ribera, Torrevieja and Elx-Crevillent respectively. Vaccine uptake was 27.9% (n = 261). According to the "Country of Origin" variable, 77.5% (n = 724) of women were Spanish, with a vaccination rate of 26.7% (n = 193), compared to 22.5% (n = 210) who were non-Spanish, with a rate of 32.4% (n = 68). The main source of information was midwives for 83.7% (n = 159) of vaccinated pregnant women and for 44.6% (n = 127) of non-vaccinated women. The main reasons for vaccine refusal were lack of awareness (29.5%, n = 84) and not considering it necessary (25.6%, n = 73). CONCLUSIONS: Despite their high willingness to be vaccinated after receiving information about the flu vaccine, the vaccination coverage in pregnant women studied is still low and can be improved. Health professionals need new information strategies to extend vaccine uptake to a larger number of pregnant women in Spain. Midwife advice plays an essential role in transmitting information on influenza vaccination in pregnant women and has a significant impact on uptake.


Assuntos
Vacinação/estatística & dados numéricos , Adulto , Estudos Transversais , Feminino , Humanos , Vacinas contra Influenza , Tocologia , Aceitação pelo Paciente de Cuidados de Saúde , Gravidez , Sistema de Registros , Espanha/epidemiologia , Inquéritos e Questionários , Recusa do Paciente ao Tratamento , Adulto Jovem
6.
BMC Public Health ; 16(1): 1173, 2016 11 21.
Artigo em Inglês | MEDLINE | ID: mdl-27871262

RESUMO

BACKGROUND: In most countries the coverage of seasonal influenza vaccination in pregnant women is low. We investigated the acceptance, reasons for rejection and professional involvement related to vaccine information in pregnant women in Valencia, Spain. METHODS: Observational retrospective study in 200 pregnant women, 100 vaccinated and 100 unvaccinated, were interviewed during the 2014/2015 vaccination campaign. Electronic medical records, immunization registry and telephone interviews were used to determine reasons for vaccination and immunization rejection. RESULTS: 40.5% of pregnant women in the health department were vaccinated. The midwife was identified as source of information for 89% of women. The vaccine was rejected due to low perceptions of risk of influenza infection (23%), lack of information (19%), considering the vaccine as superfluous (16%), close proximity of delivery date (13%) and fear of side effects (12%). CONCLUSION: Pregnant women in Spain declined to be vaccinated due to under-estimation of the risk of contracting or being harmed by influenza, and lack of information. Interventions aiming to optimize vaccination coverage should include information addressing the safety and effectiveness of the current vaccine together with improved professional training and motivation.


Assuntos
Imunização/psicologia , Influenza Humana/psicologia , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Complicações Infecciosas na Gravidez/psicologia , Gestantes/psicologia , Vacinação/psicologia , Adulto , Feminino , Humanos , Vacinas contra Influenza/uso terapêutico , Influenza Humana/prevenção & controle , Gravidez , Complicações Infecciosas na Gravidez/prevenção & controle , Estudos Retrospectivos , Estações do Ano , Espanha
7.
Euro Surveill ; 20(8)2015 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-25742432

RESUMO

Preliminary results for the 2014/15 season indicate low to null effect of vaccination against influenza A(H3N2)-related disease. As of week 5 2015, there have been 1,136 hospital admissions, 210 were due to influenza and 98% of subtype A strains were H3. Adjusted influenza vaccine effectiveness was 33% (range: 6-53%) overall and 40% (range: 13% to 59%) in those 65 years and older. Vaccination reduced by 44% (28-68%) the probability of admission with influenza.


Assuntos
Hospitalização/estatística & dados numéricos , Vírus da Influenza A/imunologia , Vacinas contra Influenza/administração & dosagem , Influenza Humana/prevenção & controle , Vacinação/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Programas de Imunização , Vírus da Influenza A/classificação , Vírus da Influenza A/isolamento & purificação , Vacinas contra Influenza/imunologia , Influenza Humana/diagnóstico , Influenza Humana/epidemiologia , Masculino , Pessoa de Meia-Idade , Avaliação de Programas e Projetos de Saúde , Fatores de Risco , Adulto Jovem
8.
An Pediatr (Barc) ; 83(5): 318-27, 2015 Nov.
Artigo em Espanhol | MEDLINE | ID: mdl-25619797

RESUMO

INTRODUCTION: In October 2008, Valencian Community started its human papillomavirus (HPV) vaccination schedules for 14 year-old girls. The aim of this study is to assess knowledge about HPV infection and its vaccine among the mothers of these girls, and to identify factors associated with the willingness to vaccinate their daughters. MATERIAL AND METHODS: Cross-sectional study by means of a questionnaire to mothers of girls born in 1995, and attending secondary schools in the province of Valencia during 2010-2011. Cluster stratified random sample (n=1279). STATISTICAL ANALYSIS: percentages, confidence intervals, OR, Chi-squared and multivariate logistic regression contrasts. RESULTS: A total of 833 (65.1%) questionnaires were completed. The results obtained showed that, 76.6% of mothers had vaccinated their daughters against HPV; 93.8% knew about the vaccine, particularly through television (71.5%); and 78.5% received positive advice from a health professional which increased the vaccination of their daughters (OR: 2.4). There was low overall knowledge about HPV infection and vaccination. Confidence of the mothers in vaccines as a preventative method increases the HPV vaccination (OR: 3.8). The first reason for refusal was the fear of adverse events (45.6%). CONCLUSIONS: Apparently, the media does not influence the willingness to vaccinate. It would be desirable to minimize the perception of risk of the vaccine. Positive health advice from a health professional can have a positive effect on vaccination. There is a gap between the level of knowledge and decision-making to vaccinate.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Mães/psicologia , Vacinas contra Papillomavirus/uso terapêutico , Aceitação pelo Paciente de Cuidados de Saúde , Meios de Comunicação , Estudos Transversais , Feminino , Humanos , Espanha
9.
An Pediatr (Barc) ; 81(5): 303-9, 2014 Nov.
Artigo em Espanhol | MEDLINE | ID: mdl-24582127

RESUMO

INTRODUCTION: In 2009, two cases of seizures in adolescents following quadrivalent human papillomavirus vaccine (qHPV) administration, generated important media attention, and adversely affected public trust in this vaccine. Our objectives were to describe suspected adverse reactions (SARs) reported to the Pharmacovigilance Centre in the Valencian Community (PCVC) after administration of HPV vaccine, and to compare reporting rates of syncope and seizures following this vaccine with those of other vaccines administered to girls aged 13-15 years. MATERIAL AND METHODS: Descriptive study of SARs reported following this vaccine to the PCVC between 2007 and 2011. RESULTS: The clinical symptoms most frequently reported were dizziness, headache, and syncope. Reporting rates of syncope or loss of consciousness and seizures with qHPV vaccine were 17 and 3.2 per 100,000 doses administered, respectively, and 15 and 1.6 for syncope or loss of consciousness and syncopal seizures occurred on the day of vaccination. The reporting rates of syncope or loss of consciousness and seizures were 6.4 and 0.4, for the other vaccines. CONCLUSIONS: Consistent with the media attention generated, and with results from other studies, the reporting rates of syncope or loss of consciousness and seizures were higher for the HPV vaccine than for other vaccines given in adolescence. Nevertheless, the overall information obtained on SARs following the qHPV vaccine suggests a good safety profile.


Assuntos
Vacina Quadrivalente Recombinante contra HPV tipos 6, 11, 16, 18/efeitos adversos , Farmacovigilância , Adolescente , Feminino , Humanos , Estudos Retrospectivos , Convulsões/epidemiologia , Convulsões/etiologia , Espanha , Síncope/epidemiologia , Síncope/etiologia , Fatores de Tempo
11.
An Sist Sanit Navar ; 36(2): 309-20, 2013 Sep 06.
Artigo em Espanhol | MEDLINE | ID: mdl-24008534

RESUMO

Over the last fifty years, the implementation of the vaccine cold chain in Spain has gone through different stages. Related published articles, from the first polio vaccination campaigns until the mid-eighties, show a rudimentary and proactive organization with limited resources. 1990 brought a stage of awareness, when national and regional healthcare authorities started to pay greater attention to appropriate material resources. Finally, the last twenty years represent a third period that has brought the modernization of resources, adoption of protocols, training of clinical personnel involved in the vaccination program, application of logistics and knowledge dissemination. Various studies and publications that have enhanced the acceptable visibility of the vaccine cold chain have been reviewed. It is after all the backbone of the vaccination programmes and though often consigned to the technicians, the vaccine cold chain requires constant training of the clinical staff that administers vaccines.


Assuntos
Refrigeração/normas , Vacinas , Humanos , Disseminação de Informação , Vacinas contra Poliovirus , Espanha
12.
An Sist Sanit Navar ; 35(2): 251-60, 2012.
Artigo em Espanhol | MEDLINE | ID: mdl-22948426

RESUMO

BACKGROUND: To assess, in the general population, the information sources, attitudes and willingness to be vaccinated against pandemic influenza A/H1N1 in 2009. METHODS: We carried out a cross sectional study between 25th November and 30th December 2009, through face to face interviews with a random sample (826) of adults resident in the Health Department of Elche (Spain). RESULTS: Respondents reported that television (57%) and the family doctor (47.9%) were their main sources of information about vaccinations. Eighty-two point two percent had a good opinion of vaccinations, 30.5% perceived A/H1N1 to be more severe than seasonal flu, with a higher rate among older and less educated people. Twenty-five point four percent of respondents were concerned about contracting it, especially among the less educated. Forty-two point one percent expressed their willingness to be vaccinated against seasonal flu. Eighteen point four percent intended to be vaccinated against A/H1N1. The bias towards vaccination increases with age and in the case of A/H1N1 decreases among more educated people. The family doctor was the main source of information when people wanted to be immunized against seasonal flu (OR = 1.43) and A/H1N1 (OR = 2.47). CONCLUSIONS: Low acceptance of the pandemic vaccination and low perceived severity of influenza A/H1N1. Previous vaccination experience with seasonal flu creates a predisposition to immunization against A/H1N1. Although the media were the leading source of information during this period, the family doctor's influence on their decision to be vaccinated was significant.


Assuntos
Informação de Saúde ao Consumidor , Vírus da Influenza A Subtipo H1N1/imunologia , Vacinas contra Influenza , Influenza Humana/prevenção & controle , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Vacinação , Adolescente , Adulto , Estudos Transversais , Feminino , Humanos , Influenza Humana/epidemiologia , Masculino , Pessoa de Meia-Idade , Pandemias , Espanha , Inquéritos e Questionários , Adulto Jovem
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