RESUMO
E. tournefortii has wound healing properties in folk medicine and 5% infusions are used for stomach ulcers. It is also used in colds, abdominal pain, digestive problems, as an appetite enhancer and antispasmodic. For this purpose, in the study biochemical and histopathological evaluation of the ulcer protective effect of the extract obtained from the E. tournefortii in the indomethacin-induced gastric ulcer model in rats was aimed to develop new strategies in the treatment of ulcers. The phytochemical profile of the plant was elucidated for the first time by LC-HRMS in this study. The results indicate that, in terms of TNF-α, IL-1ß, IL-8, IL-6, PGE2, NF-κB, VEGF, NO, COX-1 and COX-2 biochemical parameters, E. tournefortii protects the gastric mucosa to the inflammation, and also modulates the PGE2 pathway, and has a similar effect or even a more positive effect than the reference substance lansoprazole. According to LC-HRMS analysis results, chlorogenic acid, genistein and quinic acid were the main constituents of E. tournefortii extract with 1397.081, 1014.177 and 992.527µg/g extract, respectively. Considering the anti-inflammatory and antioxidant effects of these phenolic components, it is thought that the major components are responsible for the anti-ulcer activity of the E. tournefortii extract.
Assuntos
Antiulcerosos , Indometacina , Compostos Fitoquímicos , Extratos Vegetais , Úlcera Gástrica , Animais , Ratos , Compostos Fitoquímicos/farmacologia , Compostos Fitoquímicos/isolamento & purificação , Úlcera Gástrica/induzido quimicamente , Úlcera Gástrica/tratamento farmacológico , Masculino , Extratos Vegetais/farmacologia , Extratos Vegetais/química , Antiulcerosos/farmacologia , Antiulcerosos/isolamento & purificação , Ratos Wistar , Mucosa Gástrica/efeitos dos fármacos , Dinoprostona/metabolismo , Estrutura MolecularRESUMO
Linum aksehirense (Linaceae) is described as a new species known from the slopes of the Sultan Mountains in the Aksehir district of Konya in Central Anatolia (Turkey). It is most similar to L. pubescens Banks & Sol. and L. anisocalyx P.H.Davis, from which it is easily distinguished by its stem leaf shape, sepal shape and petal colour. Seed and pollen surface ornamentations were photographed under SEM microscopy to explore micromorphological characters distinguishing the new species from close relatives. In addition, photographs of living material, a distribution map, ecological details, and an identification key are provided.
RESUMO
A new species of Haplophyllum, Haplophyllumermenekense (Rutaceae) is described and illustrated in line drawing. It grows on stony slopes of Ermenek town, Karaman province, in southern Turkey. It is compared with the closely related species H.myrtifolium. H.ermenekense is distinguished from the morphologically similar H myrtifolium chiefly by sepal shape, petal size, capsule size, presence of capsule hair and appendage form. On the other hand, the seed coat and pollen grains surface of H.ermenekense and H.myrtifolium are demonstrated in SEM photographs. In addition to the detailed description, the illustration, distribution map, conservation status and ecology of the new species are also provided.
RESUMO
Antioxidant capacity, total phenol and mineral contents of aerial parts of sage belonging to some Salvia species were established. The lowest and highest antioxidant values of Salvia dichroantha Stapf and Salvia heldreichiana Boiss. ex Benth. extracts were found as 73.855 and 80.207 mg GAE/g, respectively. While the highest total phenol was established in Salvia tomentosa Mil. (13.316 mg GAE/100 ml), the lowest level was found in Salvia halophila Hedge (6.168 mg GAE/100 ml). While K contents of plants changed between 14,518 and 24,171 mg/kg, Ca contents ranged between 12,402 and 18,553 mg/kg. P and Mg contents were found low compared with K and P values of plants. Mg content was changed between 2,118 and 2,914 mg/kg; the mean was calculated as 2,496 mg/kg. P contents of plants were determined between 1,385 to 1,910 mg/kg. As a microelement, Fe was found at the highest level. Fe contents of plants were found between 179 and 782 mg/kg.