RESUMO
OBJECTIVES: 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) is a diagnostic imaging method that is based on the Warburg effect, which is the increased uptake of glucose through aerobic glycolysis in cancer cells. The diagnostic value of 18F-FDG-PET/CT for thyroid cancer is controversial. However, uptake of 18F-FDG and the corresponding maximum standardized uptake value (SUVmax) is expected to reflect the metabolic status of cancer cells. In the present study, we sought to determine the relationship between 18F-FDG uptake and tumor metabolism- associated factors. METHODS: This was a single-center retrospective study. In the present study, SUVmax was compared with the expression of hexokinase 2 (HK2), glucose transporter 1 (GLUT1), vascular endothelial growth factor (VEGF), and glutaminase 1 (GLS1) in 41 patients with thyroid cancer. RESULTS: GLS1 expression was found to be moderately correlated with SUVmax (p < 0.001, r = 0.51), whereas HK2 and VEGF expression were weakly correlated (p = 0.011, r = 0.28, p = 0.008, r = 0.29, respectively) and GLUT1 did not correlate with SUVmax (p = 0.62, r = 0.06). CONCLUSION: Our findings suggest 18F-FDG PET/CT reflects GLS1 expression in thyroid cancer and could be used to select suitable candidates for GLS1 inhibitor treatment.
Assuntos
Fluordesoxiglucose F18 , Transportador de Glucose Tipo 1 , Hexoquinase , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Compostos Radiofarmacêuticos , Câncer Papilífero da Tireoide , Neoplasias da Glândula Tireoide , Fator A de Crescimento do Endotélio Vascular , Humanos , Hexoquinase/metabolismo , Neoplasias da Glândula Tireoide/metabolismo , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Transportador de Glucose Tipo 1/metabolismo , Câncer Papilífero da Tireoide/metabolismo , Câncer Papilífero da Tireoide/diagnóstico por imagem , Pessoa de Meia-Idade , Masculino , Feminino , Estudos Retrospectivos , Adulto , Idoso , Fator A de Crescimento do Endotélio Vascular/metabolismo , Glutaminase/metabolismo , Carcinoma Papilar/metabolismo , Carcinoma Papilar/diagnóstico por imagemRESUMO
By overcoming the unwanted catalytic dimerization of terminal alkynes, palladium-catalyzed carbothiolation of alkynes with heteroaryl sulfides has been accomplished to provide the corresponding ß-heteroaryl alkenyl sulfides with high regio- and stereoselectivity. The key for the preferential arylthiolation is the use of arylsulfanyl segments, instead of alkylsulfanyl, for smooth C(heteroaryl)-SR1 bond cleavage and/or of alkylacetylenes that are reluctant to undergo the dimerization. The reaction proceeds under mild and neutral conditions, with various functionalities being thus tolerated.
RESUMO
Mizoroki-Heck-type alkenylation of monoaryldialkylsulfoniums has been accomplished by means of palladium catalysts. Various combinations of monoarylsulfoniums and alkenes were adapted to the present reaction. Because monoaryldimethylsulfoniums were readily prepared from the corresponding aryl methyl sulfides and methyl triflate, one-pot alkenylation of aryl methyl sulfide could also be executed.