RESUMO
Allergic rhinitis remains an important problem that affects people of all ages. Although allergic rhinitis is considered a trivial disease by the public and medical community alike, the evidence of allergic rhinitis as a risk factor to the development of associated diseases such as asthma, sinusitis, otitis media with effusion, and nasal polyps is better appreciated. Pathophysiology and current therapy of allergic rhinitis is reviewed.
Assuntos
Rinite Alérgica Perene/diagnóstico , Rinite Alérgica Sazonal/diagnóstico , Adolescente , Adulto , Criança , Dessensibilização Imunológica , Diagnóstico Diferencial , Feminino , Antagonistas dos Receptores Histamínicos H1/uso terapêutico , Humanos , Descongestionantes Nasais/uso terapêutico , Gravidez , Rinite Alérgica Perene/complicações , Rinite Alérgica Perene/tratamento farmacológico , Rinite Alérgica Sazonal/complicações , Rinite Alérgica Sazonal/tratamento farmacológicoRESUMO
Chronic idiopathic demyelinating polyneuropathy is an immunologically mediated disorder that may not respond to glucocorticoid therapy, cytotoxic or other immunosuppressive medications, or plasmapheresis. We have reported such a case in which the patient had sustained clinical improvement with the repeated administration of high doses of intravenous immunoglobulin.
Assuntos
Doenças Desmielinizantes/terapia , Imunoglobulinas Intravenosas/uso terapêutico , Doença Crônica , Resistência a Medicamentos , Humanos , Masculino , Pessoa de Meia-Idade , Plasmaferese , Prednisona/uso terapêuticoRESUMO
CD23 is expressed on mature B cells and is identical to a low-affinity IgE Fc epsilon receptor type II (Fc epsilon R II). The C terminal portion of CD23 is released to the serum as soluble Fc epsilon R II (sFc epsilon R II), which may be involved in regulation of IgE synthesis. We studied sFc epsilon R II levels in normal children and in patients with immunodeficiencies, including common variable immunodeficiency (CVI), partial DiGeorge syndrome, and immunodeficiency associated with ectodermal dysplasia to examine the relationship of sFc epsilon R II levels to B cell numbers and other immunoparameters. Serum Fc epsilon R II levels are higher in younger children (younger than 3 years) and decline gradually with age. In 11 patients with CVI with normal numbers of B cells (greater than 6%), sFc epsilon R II levels were comparable to that of control subjects. Five patients with CVI with deficiencies of peripheral B cells had levels of sFc epsilon R II similar to levels of control subjects. In all but one patient with partial DiGeorge syndrome, sFc epsilon R II levels were not significantly elevated, despite the presence of elevated peripheral B cell numbers. Of six patients with ectodermal dysplasia, four demonstrated increased Fc epsilon R II levels, a finding not correlated with serum IgE levels or with peripheral eosinophil or B cell numbers.