Lifestyle of type 2 diabetes mellitus patients with peripheral neuropathy: Phenomenological study.

OBJECTIVE: To explore the lifestyle-related characteristics of people having type 2 diabetes mellitus with peripheral neuropathy. METHODS: The phenomenological study was conducted from July 5 to September 18, 2021, at Sadabuan Health Centre, Batunadua Health Centre and Wek 3 Health Centre, Padangsidimpuan, Indonesia, and comprised diabetic neuropathy patients who had cognitive impairment, anxiety and depression. Data was collected using in-depth interviews. Data was analysed using Collaizi's method. RESULTS: There were 8 subjects with mean age 48.38±13,606 years (range: 27-65 years), and mean duration of diabetes was 6±3.207 years. The majority of participants in this study were women 6 (75%). There were 7 themes that emerged from the collected data: level of physical activity, diet, sleep pattern, habit of consuming sweet drinks, smoking habit, social interaction, and self-care. CONCLUSIONS: Diabetes mellitus patient with peripheral neuropathy had not been able to completely switch to a healthier lifestyle.

Obesity and Mortality of Hospitalized COVID-19 Patients in Asian and Western Countries: A Systematic Review and Meta-Analysis.

Background: The authorities recently emphasized the importance of dietary control for COVID-19 patients in hospitals. However, there is limited detail about the obesity and death of COVID-19 patients who are hospitalized in the Asian and Western countries. The aim of this study was to find the role of obesity and mortality of the hospitalized COVID-19 patients. A systematic review of the studies on obesity and mortality of hospitalized COVID.19 patients in the Asian and western countries. Methods: Databases of ProQuest, PubMed, and EBSCO were used to find relevant articles published between January 2020 and March 2021. A total of 3,70,836 patients in 17 studies were included. Results: We found significant correlation between obesity and mortality in hospitalized COVID-19 patients (pooled odds ratio [POR] = 1.28, 95% CI: 1.23-1.33). In particular, this study demonstrated that the Asian countries had higher POR (1.44, 95% CI: 1.16-1.79) compared to the western countries (1.28, 95%CI: 1.23-1.33). The heterogeneity calculation showed heterogenous among studies included (I2 > 50%). Conclusions: The mortality of COVID-19-hospitalized patients is related to obesity, which requires a multi-stakeholder mitigation approach to avoid and control obesity and its impacts. Conclusions: The mortality of COVID-19-hospitalized patients is related to obesity, which requires a multi-stakeholder mitigation approach to avoid and control obesity and its impacts.

Ocimum basilicum alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model.

OBJECTIVES: Gestational diabetes (GDM) complications affect maternal and fetus in utero. GDM's vascular dysfunction showed inducible nitric oxide synthase (iNOS) alteration and was linked to the higher production of nitrogen species, leading to diabetic embryopathy. Ocimum basilicum (O. basilicum) has been reported for its anti-inflammatory and anti-diabetic effects. Thus, the present study investigates the anti-diabetic effect, lipid-lowering effect, and iNOS expression in GDM animal models treated with O. basilicum extract. EXPERIMENTAL PROCEDURES: Four groups of pregnant rats consist of control and GDM groups. One GDM group was set for control positive. Two GDM groups were treated with O. basilicum extract in two doses (100 and 200 mg/kg BW) for 14 days. Blood glucose of all groups was observed at 72 h after STZ injection and 14 days after administration of O. basilicum extract. Lipid profile and iNOS expression using real-time PCR were measured afterward. RESULTS: O. basilicum extract lowered blood glucose levels in both doses, from 262.60 mg/dL±6.89-136.80 mg/dL ± 15.6 mg/dL and 113.20 mg/dL±5.25 mg/dL. Total cholesterol, LDL and triglyceride showed a reduction, especially in 200 mg/kg BW dose extract from 122.37 mg/dL ± 14.84 mg/dL, 69.75 mg/dL±3.78 mg/dL and 137.51 mg/dL ± 8.12-74.64 mg/dL±8.71 mg/dL, 40.26 mg/dL±3.31 mg/dL and 87.57 mg/dL±6.29 mg/dL, respectively. iNOS expression downregulated in both doses, from 2.17±0.39 to 0.94±0.3 and 0.41±0.08. CONCLUSIONS: This study showed that O. basilicum extract has a potential therapeutic activity in lowering blood glucose, improved lipid profile, and downregulating iNOS in GDM.

Acceptance of COVID-19 vaccination and correlated variables among global populations: A systematic review and meta-analysis.

INTRODUCTION: The most awaited solution is an efficient COVID-19 vaccine. COVID-19 vaccine acceptance has not been studied in a meta-analysis. The objective of this research was to find the acceptance of COVID-19 vaccination and correlated variables. METHODS: A systematic review of studies on acceptance of COVID-19 vaccination and correlated variables in the ProQuest, PubMed, and EBSCO to find relevant articles published between January 2020 and March 2021. Using fixed and random-effect models, the risk factors Pooled Odds Ratio (POR) were measured. The heterogeneity was calculated using the I-squared formula. Egger's and Begg's tests were utilised to determine publication bias. STATA 16.0 was used for all data processing and analysis. RESULTS: This study results showed the related factors for COVID-19 vaccination acceptance, high income has the highest odd ratio (POR = 2.36), followed by encountered with COVID-19 (POR = 2.34), fear about COVID-19 (POR = 2.07), perceived benefits (POR = 1.81), flu vaccine during the previous season (POR = 1.69), healtcare workers (POR = 1.62), male (POR = 1.61), married (POR = 1.59), perceived risk (POR = 1.52), trust in health system (POR = 1.52), chronic diseases (POR = 1.47), high education (POR = 1.46), high level of knowledge (POR = 1.39), female (1.39), and older age (POR = 1.07). The heterogeneity calculation showed homogenous among studies in high income, fear about COVID-19, healthcare workers, married, chronic diseases, and female (I2 ≤ 50%). For the studies included in this review, there was no apparent publication bias. CONCLUSION: The analysis of this review may be useful to the nation in determining the best method for implementing COVID-19 mass vaccination programs based on relevant factors that influence vaccine acceptance.

Dataset of Indonesian women's reproductive, high-fat diet and body mass index risk factors for breast cancer.

This dataset describes a survey presenting reproductive, high-fat diet and body mass index (BMI) determinant factors for breast cancer among Indonesian women. The information was gathered from breast cancer and non-breast cancer patients via an online questionnaire, determining reproductive factors (menarche age, menopause age, first pregnancy age, parity, and breastfeeding), high-fat diet and BMI, from 1st June until 31th September 2020. Two hundred breast cancer patients and 200 non-breast cancer patients in Indonesia willing to fill out an online survey provided the samples. The data was analyzed using IBM version 25.0, which included univariate, bivariate, and multivariate analysis. The information would help Indonesian women in identifying the potential of breast cancer.