[Comparative study of anticoagulants obtained from various extracts of Paeonia anomala]. / Sravnitel'nye issledovaniia antikoagulantov iz razlichnykh ékstraktov Paeonia anomalia.

We have established that extracts prepared from various parts of the root of Paeonia anomala (bark and wood) have anticoagulant activity as indicated by the criterion of longer recalcification time of the normal rat blood plasma. This anticoagulant activity is due to the presence of heparin-like fragments in the preparations, which follows from the results of biochemical analysis and results of studies on the functional state of the mast cell population. Preparations from the peony root bark retain their anticoagulant properties in the circulatory system for 1.5 h after intravenous administration, similarly to heparin of the animal origin.

[Effect of a peony root preparation on the status of the insulin and hemostatic system in animals during development of alloxan diabetes]. / Vliianie preparata iz kornei piona na sostoianie insuliarnoi i gemostaticheskoi sistem zhivotnykh pri razvitii alloksanovogo diabeta.

Administration of peony roots preparations provides the stable prophylactic effect against the development of experimental alloxan diabetes. This preparation and its complex with aspirin conserves the normal hemostatic system status and moderates the insular system disturbances. These preparations provide greater survival of animals.

[The nature of an anticoagulant isolated from peonies in the central zone of Russia]. / K voprosu o prirode antikoagulianta, poluchennogo iz pionov srednei polosy Rossii.

The nature of the anticoagulant isolated from the Chinese peony roots has been determined. Physicochemical analysis (infrared and mass spectroscopy, and polyacrylamide gel electrophoresis) demonstrated the presence of a glycopeptide in Paeonia suffraticosae roots. This glycopeptide shares a structural similarity with heparin.

[An anticoagulant from extracts of peony roots: its isolation and properties]. / Antikoagulant iz ékstraktov kornei pionov: poluchenie i svoistva.

A protein-free anticoagulant preparation displaying anticoagulative but not fibrinolytic activity in vitro was isolated from peony. Electrophoretic, chromatographic, and spectral analyses revealed that this anticoagulant resembles animal heparin: it contains sulfur, carbon, and nitrogen in quantities characteristic of the latter. Plant heparin enhances anticoagulative and fibrinolytic plasma properties and decreases platelet aggregation. It may be used as a harmless and ecologically pure anticoagulant.