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2.
Clin Exp Dermatol ; 47(1): 129-135, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34260077

RESUMO

Mixed vascular naevus (MVN) is characterized by the co-occurrence of telangiectatic capillary malformation and naevus anaemicus, which can appear as a pure cutaneous phenotype or be combined with systemic manifestations such as brain malformations, neurological abnormalities and musculoskeletal disorders. Recently, GNA11 and GNAQ somatic mutations have been reported in some patients with isolated and syndromic MVN. We report three children with MVN syndrome with generalized cutaneous manifestations and a number of systemic associations not reported to date, including ophthalmological anomalies, musculoskeletal abnormalities such as Sprengel deformity and posterior vertebral fusion anomalies, and septal heart defects. We also confirm a somatic mutation of GNA11 in both telangiectatic naevus and naevus anaemicus in two of our patients and discuss a possible common pathogenic mechanism underlying the different manifestations of the syndrome. Currently, there are no guidelines for the evaluation of patients with MVN syndrome, but according to the different known aspects of the disease, a complete clinical examination should be made, and complementary laboratory and imaging tests should be considered.


Assuntos
Capilares/anormalidades , Subunidades alfa de Proteínas de Ligação ao GTP/genética , Mutação , Nevo/genética , Telangiectasia/genética , Malformações Vasculares/genética , Anormalidades Múltiplas/genética , Anormalidades Múltiplas/patologia , Capilares/patologia , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Nevo/patologia , Síndrome , Telangiectasia/patologia , Malformações Vasculares/patologia
4.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33636161

RESUMO

The development of perianal ulcers related to the use of a hemorrhoidal ointment has not been reported in the literature. We describe a series of 11 patients who were treated for perianal ulcers in 10 Spanish hospitals after they used the same ointment containing the active ingredients triamcinolone acetonide, lidocaine, and pentosan polysulfate sodium. No prior or concomitant conditions suggesting an alternative cause for the condition could be identified, and after the patients stopped using the ointment, their ulcers cleared completely in 8 weeks on average. This case series shows the damage that can be caused by an over-the-counter pharmaceutical product used without medical follow-up. It also illustrates the need to ask patients with perianal ulcers about any topical agents used before the lesions appeared.

7.
Actas Dermosifiliogr (Engl Ed) ; 109(8): e11-e16, 2018 Oct.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-29397873

RESUMO

Blisters associated with PUVA treatments are an adverse effect of photochemotherapy that has been reported in the literature. Asymptomatic blisters appear spontaneously mainly on the lower limbs and resolve without treatment. The differential diagnoses to consider include a phototoxic reaction, pseudoporphyria, and PUVA-induced bullous pemphigoid. We describe the clinical and histologic features in 5 cases of blistering secondary to PUVA treatment. If this adverse effect is accurately diagnosed, photochemotherapy need not be interrupted, and unnecessary diagnostic procedures and additional treatments can be avoided.


Assuntos
Vesícula/etiologia , Terapia PUVA/efeitos adversos , Adulto , Idoso , Idoso de 80 Anos ou mais , Vesícula/diagnóstico , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Micose Fungoide/tratamento farmacológico , Parapsoríase/tratamento farmacológico , Penfigoide Bolhoso/diagnóstico
14.
Clin Exp Dermatol ; 42(1): 58-60, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27900796

RESUMO

Parvovirus B19 infection can cause a wide range of cutaneous manifestations, including papular-purpuric gloves-and-socks syndrome (PPGSS) and petechial bathing trunk eruption. We report a case of an immunocompetent woman with a primary parvovirus B19 infection presenting as concurrent PPGSS and petechial bathing trunk eruption. Parvovirus B19 seroconversion was confirmed several days after the onset of the clinical manifestations. The coexistence of these two cutaneous manifestations of primary parvovirus B19 infection has rarely been reported in the literature. It is important to recognize parvovirus B19 infection early, based on the cutaneous manifestations, to avoid potentially serious systemic complications in susceptible individuals.


Assuntos
DNA Viral/análise , Derme/patologia , Eritema Infeccioso/diagnóstico , Dermatoses do Pé/diagnóstico , Dermatoses da Mão/diagnóstico , Parvovirus B19 Humano/genética , Tronco/patologia , Biópsia , Derme/virologia , Eritema Infeccioso/virologia , Feminino , Dermatoses do Pé/virologia , Dermatoses da Mão/virologia , Humanos , Pessoa de Meia-Idade , Parvovirus B19 Humano/isolamento & purificação , Reação em Cadeia da Polimerase , Síndrome
15.
Actas Dermosifiliogr ; 107(6): e39-45, 2016.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-26952201

RESUMO

Annular lichenoid dermatitis of youth is a lichenoid dermatosis of unknown etiology. It mostly affects children and adolescents and has well-defined clinical and histological characteristics that permit a diagnosis. We present 2 new cases of annular lichenoid dermatitis of youth with classical clinical features in 2 girls, aged 2 and 4 years. The histologic findings, however, differed from those reported in the literature in that the lichenoid inflammatory infiltrate was located primarily at the top of the dermal papillae and not at the tips of the rete ridges. In both cases, the lesions regressed spontaneously without treatment.


Assuntos
Erupções Liquenoides/patologia , Pré-Escolar , Feminino , Humanos
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