1.
Eur J Med Chem
; 40(11): 1143-8, 2005 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16040160
RESUMO
Spiro derivatives of oxindole and isoxazole-5-one were synthesized by using Michael addition reaction, highlighting the regioselective approach towards the synthesis of Michael diadduct followed by condensation of Michael diadduct. The spiro compound 4 showed antitubercular activity against Mycobacterium tuberculosis H37Rv whereas spiro compound 9 possesses pronounced anticancer and antibacterial profile.