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Drug Discov Today ; 28(7): 103626, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37224998

RESUMO

Antineoplastic treatment induces a type of gastrointestinal toxicity known as mucositis. Findings in animal models are usually easily reproducible, and standardized treatment regimens are often used, thus supporting translational science. Essential characteristics of mucositis, including intestinal permeability, inflammation, immune and oxidative responses, and tissue repair mechanisms, can be easily investigated in these models. Given the effects of mucositis on the quality of life of patients with cancer, and the importance of experimental models in the development of more effective new therapeutic alternatives, this review discusses progress and current challenges in using experimental models of mucositis in translational pharmacology research.


Assuntos
Antineoplásicos , Mucosite , Animais , Mucosite/induzido quimicamente , Mucosite/tratamento farmacológico , Roedores , Qualidade de Vida , Antineoplásicos/toxicidade , Desenvolvimento de Medicamentos , Mucosa Intestinal
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