[Therapy of asthenic disorders after psychotic conditions in patients with cognitive impairment: results of an observational non-interventional program]. / Terapiya astenicheskikh rasstroistv posle perenesennykh psikhoticheskikh sostoyanii u patsientov s kognitivnymi narusheniyami: rezul'taty nablyudatel'noi neinterventsionnoi programmy.

OBJECTIVE: An observational non-interventional study was conducted to obtain data on the efficacy and safety of Prospekta in the treatment of postpsychotic asthenia in patients with cognitive impairment (CI). MATERIAL AND METHODS: We selected 69 patients aged 18-75 years with asthenic disorders that developed after suffering psychotic conditions and CI, who were prescribed Prospekta. At four visits (at baseline, after 2, 4 and 8 weeks), the doctor collected complaints, anamnesis, examined the patient, assessed the severity of asthenia on the MFI-20 (The Multidimensional Fatigue Inventory-20) scale, CI - on the MMSE (The Mini-mental state examination). Concomitant diseases and maintenance therapy of the underlying disease were recorded, and the safety of treatment with Prospect was evaluated. At the last visit, the doctor's clinical impression was assessed using the CGI-I (Clinical Global Impression - Global Improvement Scale). RESULTS: The analysis included data from 69 patients (mean age 45.7 years), of which 27 (33.4%) were women. Prospekta reduced the severity of asthenia on the MFI-20 scale from 85.7±6.6 to 51.6±7.1 points, including general asthenia, mental and physical asthenia, and contributed to an increase in activity and motivation (p<0.001). 8-week treatment with Prospekta improved cognitive function on the MMSE scale from 25.7±3.7 to 28.8±1.5 points (p<0.001). There was no effect of the drug on blood pressure, heart rate. 76 adverse events (AEs) were detected in 22 patients, of which 62 AEs (82%) were of mild severity, 14 AEs (18%) were of moderate severity. A causal relationship of AEs with taking Prospekta, according to doctors, was absent in 48 (63%) cases. CONCLUSION: Prospekta is an effective and safe drug for the treatment of asthenic disorders that have developed after suffering psychotic conditions in patients with CI.

Ipidacrine in combination therapy regimens of functional constipation.

AIM: Analysis of the treatment response rates of different therapy regimens of functional constipation, including Ipidacrine, a cholinesterase inhibitor, based on assessment of adaptation and compensatory mechanisms in the therapy forecast. MATERIALS AND METHODS: 77 functional slow-transit constipation patients were examined after therapy regimens of functional constipation, the mean age is 44.30±14.58 y.o. RESULTS: The treatment response rates of different therapies with Ipidacrine depends on the patient's initial adaptation and compensatory mechanisms (ACM index); certain aspects allowing to predict the expected result depending on the current mental state were identified; the severity of the state of functional constipation, ACM index and MMPI test psychometric indicators are correlated; adaptation and compensatory mechanisms of functional constipation patients were found to be reduced; the prognosis of the treatment response rates and, accordingly, the choice of the therapy regimen depend on the patient's adaptation potential (index). CONCLUSION: Therapy regimens for functional constipation patients should be selected on the basis of the original ACM index, behavioral pattern, degree of compliance and the patient's age.

[Diagnosis and treatment of neurogenic dysphagia after acute ischemic stroke]. / Diagnostika i lechenie neirogennoi disfagii u bol'nykh, perenesshikh ostryi karotidnyi ishemicheskii insul't.

AIM: To determine the efficacy of post-stroke dysphagia treatment by choline alfoscerate (ChA), succinate combination (SC), and their combination with sip, larynx, and swallowing exercises. MATERIAL AND METHODS: Four groups of primary ischemic stroke (IS) patients (n=80; 62±0.2 y.o., verified by MRI), including controls, admitted to Stroke Unit 24 h after stroke in the area of RAM (29.5%), and LAM (70.5%), were studied. Basic therapy was provided according to National Stroke Treatment Recommendations, treated groups received ChA 14 mg/kg (2st gr.), SC 0.5 mg/kg (3nd gr.), combination of two compounds (3d gr.). Controls (4th gr.) received placebo. Pharmacological treatment was provided for 10 days with continuation by oral administration. Dysphagia was measured semi-quantitively by MASA scale, three scale determinants were measured on admission, on 5 and 13 days of stay in the hospital. RESULTS AND CONCLUSION: The differences were significant and observed on the 5th day of treatment. ChA mostly improved sip control, and larynx movements (38% above controls; p<0.01), while SC improved the closure of vocal cords (55% above controls; p<0.01). This may reflect the differences in synaptic control of these functions. Combined treatment was more effective than monotherapy: 15% above ChA, and 21% above SC for swallowing function (p=0.01); 33 and 22% for vocal closure, 37% (p=0.05) and 76% (p=0.01) for larynx movement, which may be due to synergism between two medications. Therefore, sip, larynx, and swallowing exercises with pharmacological support of ChA and SC ameliorated dysphagia after IS.

[Clinical and neurophysiological parameters in patients with discirculatory encephalopathy].

We studied clinical parameters and characteristics of the nonspecific brain activity, reflecting interhemispheric interactions, in patients with discirculatory encephalopathy (DEP) who had arterial hypertension. Forty-six patients with DEP (25 - with DEP, II stage, 21 - with DEP, III stage) without epileptic changes on EEG were examined. The control group included 44 healthy people. EEG was assessed using the visual analysis according to E.A. Zhimunskaya, spectral analysis programs with mapping, degree of interhemispheric asymmetry of brain biopotential power. The more severe was the disease, the lower was the power of brain bioelectric activity. Variants of functioning of nonspecific brain activity in different stages of DEP were found in the study of the degree of interhemispheric asymmetry of brain biopotential power. The activity of synchronization areas of the brain dominated in the initial DEP stages, and that of desynchronization areas - in the later stages.

Tenoten in the therapy of anxious disturbances in patients with essential hypertension and coronary heart disease.

The study demonstrated high anxiolytic activity of tenoten, which was not inferior to the anxiolytic effect of grandaxin. The positive changes persisted after termination of treatment in the tenoten group (but not in grandaxin group). Tenoten can be recommended for the treatment of patients with cardiovascular diseases associated with neurotic disturbances.

[Chronic pancreatitis and alcoholism (the need for continuous treatment)]. / Khronicheskii pankreatit i alkogolizm (neobkhodimost' preemstvennogo lecheniia).

It was shown that the absence of the alcoholic treatment was responsible for the deterioration of the patient's condition after the operation for chronic pancreatitis of the alcoholic nature and resumption of taking alcohol. Labour rehabilitation of the patients made up as little as 50%. Psychotherapy and psychopharmacotherapy of alcoholism if performed before and after operation under conditions of specialized hospitals resulted in a considerable improvement of the patients' condition, in better labour and social rehabilitation of patients with chronic alcoholic pancreatitis. Labour rehabilitation in such patients made up 80%.

[A psycholinguistic method in the complex differential diagnostic examination of patients with abdominal pain syndromes]. / Psikholingvisticheskii metod v kompleksnom differentsial'no-diagnostichesmom obsledovanii bol'nykh s abdominal'nymi bolevymi sindromami.

Speech traits were studied in 48 patients with abdominal pain. In cases of somatic pain the total number of associations in the speech was reduced and associations with notions "life" and "man" actualized. With psychogenic mechanisms participating in the pain syndromes the number of associations increased and these with notions "pain" and "disease" actualized. These traits may have the differential diagnostic and forensic value.

[Anti-alcoholic therapy in the complex treatment of patients with primary chronic recurrent pancreatitis and alcoholism]. / Protivoalkogol'naia terapiia v kompleksnom lechenii bol'nykh pervichnym khronicheskim retsidiviruiushchim pankreatitom i alkogolizmom.

On the basis of the examination of 30 patients the authors have concluded that to improve the efficacy of the treatment of chronic relapsing painful pancreatitis combined with alcoholism, it is necessary that the diagnosis and treatment of alcoholism be included into the multiple-modality therapy of these patients during their stay in surgical hospitals. The prognosis of alcoholism development should be taken into account in selecting therapeutic policy for such patients. Thus, it is recommended that full-scale surgical intervention be performed in patients with a low risk of a relapse of alcoholism in the postoperative period. In conducting antialcoholic treatment preference should be given to psychopharmacotherapy and psychotherapy because of the gravity of the patients' somatic status.