RESUMO
Advancements in microscopy techniques and computing technologies have enabled researchers to digitally reconstruct brains at micron scale. As a result, community efforts like the BRAIN Initiative Cell Census Network (BICCN) have generated thousands of whole-brain imaging datasets to trace neuronal circuitry and comprehensively map cell types. This data holds valuable information that extends beyond initial analyses, opening avenues for variation studies and robust classification of cell types in specific brain regions. However, the size and heterogeneity of these imaging data have historically made storage, sharing, and analysis difficult for individual investigators and impractical on a broad community scale. Here, we introduce the Brain Image Library (BIL), a public resource serving the neuroscience community that provides a persistent centralized repository for brain microscopy data. BIL currently holds thousands of brain datasets and provides an integrated analysis ecosystem, allowing for exploration, visualization, and data access without the need to download, thus encouraging scientific discovery and data reuse.
RESUMO
Parkinson's disease (PD) targets some dopamine (DA) neurons more than others. Sex differences offer insights, with females more protected from DA neurodegeneration. The mammalian vesicular glutamate transporter VGLUT2 and Drosophila ortholog dVGLUT have been implicated as modulators of DA neuron resilience. However, the mechanisms by which VGLUT2/dVGLUT protects DA neurons remain unknown. We discovered DA neuron dVGLUT knockdown increased mitochondrial reactive oxygen species in a sexually dimorphic manner in response to depolarization or paraquat-induced stress, males being especially affected. DA neuron dVGLUT also reduced ATP biosynthetic burden during depolarization. RNA sequencing of VGLUT+ DA neurons in mice and flies identified candidate genes that we functionally screened to further dissect VGLUT-mediated DA neuron resilience across PD models. We discovered transcription factors modulating dVGLUT-dependent DA neuroprotection and identified dj-1ß as a regulator of sex-specific DA neuron dVGLUT expression. Overall, VGLUT protects DA neurons from PD-associated degeneration by maintaining mitochondrial health.
RESUMO
Stable dissipative solitons are perfect carries of optical information due to remarkable stability of their waveforms that allows the signal transmission with extremely dense soliton packing without losing the encoded information. Apart from unaffected passing of solitons through a communication network, controllable transformations of soliton waveforms are needed to perform all-optical information processing. In this paper we employ the basic model of dissipative optical solitons in the form of the complex Ginzburg-Landau equation with a potential term to study the interactions between two stationary dissipative solitons under the control influences and use those interactions to implement various logic gates. In particular, we demonstrate not, and, nand, or, nor, xor, and xnor gates, where the plain (fundamental soliton) and composite pulses are used to represent the low and high logic levels.
RESUMO
We propose a mechanism to control propagation of a group of stable dissipative solitons in a nonlinear magneto-optic planar waveguide. The control is realized by means of a spatially inhomogeneous external magnetic field, which is induced by a set of direct conducting wires placed on the top of the guiding layer. The wires are extended in the direction of soliton propagation, and carry electric currents with particular piecewise constant profiles. In order to describe the soliton evolution the one-dimensional cubic-quintic complex Ginzburg-Landau equation has been adapted by tailoring an additional linear term, which is responsible for the magneto-optic effect.
