1.
Bioorg Med Chem Lett
; 30(12): 127192, 2020 06 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32312582
RESUMO
The identification of a novel series of DprE1 inhibitors based on a 2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-N-phenylpropanamide scaffold is described herein. SAR exploration around the HTS hit 1 led to the identification of multiple analogues with potent DprE1 inhibition and good whole-cell antimycobacterial activity.