[Metabolic and genetic predictors of restenosis and thrombosis of arterial bioprostheses in the femoropopliteal position].

The present study was aimed at analysing the role of certain cytokines in the development of restenosis and thrombosis of biological prostheses "KemAngioprosthesis", as well as assessing the effect of polymorphic variants of genes on expression of pro- and anti-inflammatory interleukins. Group One (n=52) was composed of patients with an unfavourable outcome (prosthesis restenosis, accompanied by thrombosis in 35 patients). Group Two (n=59) comprised patients with functioning and unaltered prostheses. Group One patients were found to have a significantly higher level of the marker of chronic inflammation IgG and IL-8, amounting respectively to 22.43±0.75 mg/ml and to 6.34±1.008 pg/ml and 16.35±0.84 mg/ml (p=0.01) and 3.96±0.399 pg/ml (p=0.01) in Group Two patients. Analysing the effect of polymorphic variants of genes on expression of pro- and anti-inflammatory interleukins showed that polymorphism of genes of proinflammatory cytokines (TNFα, IL-8 and IL-6) is high producing and polymorphism of the gene of anti-inflammatory cytokine IL-10 is low producing. Besides, we noted a clear-cut tendency toward higher incidence of polymorphic alleles of genes of proinflammatory cytokines in Group One patients.

[Predictors of stent thrombosis in patients with ST-elevation acute coronary syndrome subjected to primary coronary artery intervention].

Basing on complex evaluation of clinical, angiographic, and laboratory data we revealed predictors of stent thrombosis in patients with ST-elevation acute coronary syndrome (ACS) subjected to percutaneous coronary interventions (PCI). Among studied sample of patients (n=124) we distinguished a group of patients with proven stent thrombosis at various stages of follow-up (n=22, group 1) and a group of patients with favorable outcome (n=102, group 2). Unifactorial analysis revealed unfavorable prognostic influence (p=0.025) of hemodynamically significant stenosis of proximal segment of anterior distending artery, disturbances of rhythm and conduction (p=0.0002), as well as degree of heart failure (HF) according to Killip on day 1 of development of symptoms of ACS, and also of high selectin P level on day 10 (p=0.031). With the aim of assessment of prognostic significance of revealed factors we conducted stepwise discriminant analysis according to results of which most significant parameter affecting development of stent thrombosis in patients with ST-elevation ACS appeared to be high Killip class of HF (p<0.0003), to a lesser degree - elevated level of sP-selectin on day 10 of observation (p=0.005). Parameter for which prognostic significance was not revealed as a result of multifactorial analysis was lesion in proximal segment of anterior descending artery (p=0.496). Probability of correct classification of the model was 88.7% at p<0.0001.

Hepatoprotective and antioxidant activity of meadowsweet extract during experimental toxic hepatitis.

The extract of meadowsweet aerial parts exhibits hepatoprotective and antioxidant activity during experimental toxic CCl(4) hepatitis. This extract improved liver function. Meadowsweet extract in 70% ethanol (100 mg/kg) was most potent and exhibited low toxicity. By several parameters the effectiveness of this extract surpassed that of Carsil.