RESUMO
Serological indicators for disease activity and portal vein obstruction and/or deviation were assessed in 23 patients with hepatosplenic schistosomiasis before, and up to 18 months after, praziquantel treatment, as well as in 25 matched local controls. Cessation of egg-induced immunopathology was reflected by the return to normal of serum procollagen-III-propeptide and neopterin concentrations. Reversibility of portal vein pathology was indicated by normal clearance of cholylglycine in cases without signs of decompensating portal hypertension. In most patients with a history of ascites and/or haemorrhage, serum cholylglycine concentration remained pathological. The results provide evidence that the fibrogenic process ceases after specific chemotherapy, and that portal vein pathology regresses in a substantial proportion of hepatosplenic schistosomiasis cases.
Assuntos
Biopterinas/análogos & derivados , Ácido Glicocólico/sangue , Hepatopatias Parasitárias/sangue , Fragmentos de Peptídeos/sangue , Praziquantel/uso terapêutico , Pró-Colágeno/sangue , Esquistossomose mansoni/sangue , Esplenopatias/sangue , Adolescente , Adulto , Ascite , Biomarcadores/sangue , Biopterinas/sangue , Criança , Feminino , Humanos , Hepatopatias Parasitárias/tratamento farmacológico , Hepatopatias Parasitárias/fisiopatologia , Masculino , Pessoa de Meia-Idade , Neopterina , Fluxo Sanguíneo Regional , Esquistossomose mansoni/tratamento farmacológico , Esquistossomose mansoni/fisiopatologia , Esplenopatias/tratamento farmacológico , Esplenopatias/fisiopatologia , Fatores de TempoRESUMO
Interleukin 2 (IL-2) and gamma interferon (IFN-gamma) were determined in supernatants of mitogen- and antigen-driven cell cultures from patients with hepatosplenic or intestinal schistosomiasis. Skin reactivity was tested using a panel of eight recall antigens. Results were compared with those of uninfected local controls. In both schistosomiasis groups, IL-2 activity was reduced before treatment. In less than one third of the patients, schistosomal antigens elicited detectable IL-2 activity. IFN-gamma production was reduced more severely in hepatosplenic cases, in particular after stimulation by anti-CD3 monoclonal antibodies. After anti-schistosomal therapy with praziquantel, mitogen-induced IL-2 and IFN-gamma activities became normal within 3 months in intestinal schistosomiasis, and within 6 months in the hepatosplenic patient group. Results of in vivo delayed-type hypersensitivity tests paralleled those of in vitro lymphokine production. In conclusion, evidence is presented for severe, antigen-unspecific suppression of lymphokine production and skin reactivity against recall antigens. Anti-parasitic chemotherapy is shown to reverse the impairment of cell-mediated immune responses at the cytokine level.