Auxiliary device for calibration of roller pumps: development and experimental results.

INTRODUCTION: Roller pumps are commonly used in surgeries involving extracorporeal circulation and its regulation may influence the hemolysis rate. OBJECTIVE: To describe an auxiliary device for adjusting roller pumps using the dynamic calibration method and show preliminary results of its application in surgical procedures. METHOD: The device was tested in the laboratory environment with three disposable pressure transducers normally used in surgeries. In the operation room, tests were carried out with two groups of patients. Free hemoglobin plasma rates were measured, 5 minutes after perfusion started and immediately before the passage of the residual volume of the pump. For Group 1 (n = 22), occlusion measurements were carried out using the drop rate method and for Group 2 (n = 18), measurements were carried out using the auxiliary device and 300 mmHg calibration (mean pressure for the dynamic calibration method). RESULTS: The auxiliary calibration device has shown calibration results statistically equal to those obtained with a reference device in the laboratory environment. We have found less variability of hemolysis rates in the operating room, using the auxiliary device and we did not observe any influence of unbalanced rollers in the hemolysis rates.

Standardization of an isolated pig heart preparation with parabiotic circulation: methodological considerations

In the present study we standardized an experimental model of parabiotic circulation of isolated pig heart. The isolated heart was perfused with arterial blood from a second animal as support and submitted to regional ischemia for 30 min, followed by total ischemia for 90 min and reperfusion for 90 min. Parameters for measurement of ventricular performance using different indices measured directly or indirectly from intraventricular pressure were defined as: maximum peak pressure, final diastolic pressure, pressure developed, first derivative of maximum pressure (dP/dt max), first derivative of minimum pressure (dP/dt min), systolic stress of the left ventricle (sigmas), and maximum elastance of the left ventricle. Isolated hearts subjected to regional and global ischemia presented significant worsening of all measured parameters. Less discriminative parameters were dP/dt max and dP/dt min. Elastance was the most sensitive parameter during the reperfusion period, demonstrating an early loss of ventricular function during reperfusion. The model proved to be stable and reproducible and permitted the study of several variables in the isolated heart, such as ischemia and reperfusion phenomena, the effects of different drugs, surgical interventions, etc. The model introduces an advantage over the classical models which use crystalloid solutions as perfusate, because parabiotic circulation mimics heart surgery with extracorporeal circulation

Standardization of an isolated pig heart preparation with parabiotic circulation: methodological considerations.

In the present study we standardized an experimental model of parabiotic circulation of isolated pig heart. The isolated heart was perfused with arterial blood from a second animal as support and submitted to regional ischemia for 30 min, followed by total ischemia for 90 min and reperfusion for 90 min. Parameters for measurement of ventricular performance using different indices measured directly or indirectly from intraventricular pressure were defined as: maximum peak pressure, final diastolic pressure, pressure developed, first derivative of maximum pressure (dP/dt max), first derivative of minimum pressure (dP/dt min), systolic stress of the left ventricle (sigmas), and maximum elastance of the left ventricle. Isolated hearts subjected to regional and global ischemia presented significant worsening of all measured parameters. Less discriminative parameters were dP/dt max and dP/dt min. Elastance was the most sensitive parameter during the reperfusion period, demonstrating an early loss of ventricular function during reperfusion. The model proved to be stable and reproducible and permitted the study of several variables in the isolated heart, such as ischemia and reperfusion phenomena, the effects of different drugs, surgical interventions, etc. The model introduces an advantage over the classical models which use crystalloid solutions as perfusate, because parabiotic circulation mimics heart surgery with extracorporeal circulation.

Mitral valve repair with a malleable bovine pericardium ring.

OBJECTIVE: To describe a surgical procedure utilizing a malleable bovine pericardium ring in mitral valve repair and clinical and Doppler echocardiographic results. METHODS: Thirty-two (25 female and 7 male) patients, aged between 9 and 66 (M=36.4+/-17.2) years, were studied over a 16-month period, with 100% follow-up. In 23 (72%) of the patients, the mitral approach was the only one applied; 9 patients underwent associated operations. The technique applied consisted of measuring the perimeter of the anterior leaflet and implanting, according to this measurement, a flexible bovine pericardium prosthesis for reinforcement and conformation of the posterior mitral annulus, reducing it to the perimeter of the anterior leaflet with adjustment of the valve apparatus. RESULTS: The patient survival ratio was 93.8%, with 2 (6.2%) fatal outcomes, one from unknown causes, the other due to left ventricular failure. Only one reoperation was performed. On Doppler echocardiography, 88% of the patients had functional recovery of the mitral valve (50% without and 38% with mild insufficiency and no hemodynamic repercussions). Of four (12%) of the remaining patients, 6% had moderate and 6% had accented insufficiency. Twenty-eight percent of class II patients and 72% of class III patients passed into classes I (65%), II (32%), and III (3%), according to NYHA classification criteria. CONCLUSION: Being flexible, the bovine pericardium ring fit perfectly into the valve annulus, taking into account its geometry and contractility. Valve repair was shown to be reproducible, demonstrating significant advantages during patient evolution, which did not require anticoagulation measures.

Invasive hemodynamic monitoring in the postoperative period of cardiac surgery.

OBJECTIVE: To assess the hemodynamic profile of cardiac surgery patients with circulatory instability in the early postoperative period (POP). METHODS: Over a two-year period, 306 patients underwent cardiac surgery. Thirty had hemodynamic instability in the early POP and were monitored with the Swan-Ganz catheter. The following parameters were evaluated: cardiac index (CI), systemic and pulmonary vascular resistance, pulmonary shunt, central venous pressure (CVP), pulmonary capillary wedge pressure (PCWP), oxygen delivery and consumption, use of vaso-active drugs and of circulatory support. RESULTS: Twenty patients had low cardiac index (CI), and, 10 had normal or high CI. Systemic vascular resistance was decreased in 11 patients. There was no correlation between oxygen delivery (DO2) and consumption (VO2), p = 0.42, and no correlation between CVP and PCWP, p = 0.065. Pulmonary vascular resistance was decreased in 15 patients and the pulmonary shunt was increased in 19. Two patients with CI < 2 L/min/m2 received circulatory support. CONCLUSION: Patients in the POP of cardiac surgery frequently have a mixed shock due to the systemic inflammatory response syndrome (SIRS). Therefore, invasive hemodynamic monitoring is useful in handling blood volume, choice of vasoactive drugs, and indication for circulatory support.

[High output heart failure due to coronary fistula]. / Insuficiência cardíaca de alto débito devida a fístula coronária.

A 45 year-old woman complaining of heart failure symptoms (New York Heart Association--class III) and a non typical thoracic pain was submitted to a transthoracic echocardiogram which showed a very dilated coronary artery and a fistula to the right atrium. The angiograms confirmed the same findings. She underwent open heart surgery which confirmed the diagnosis. Fistula ligation was then undertaken. She remains symptom-free three years after the operation.

[Use of a thin retrocardiac drain after open heart surgery. Description of the technique]. / Uso de dreno fino retrocardíaco em pós-operatório de cirurgia cardíaca. Descrição de técnica.

PURPOSE: To describe a technique with a thin drainage system placed behind the heart, avoiding reoperation caused by tamponade due to pericardial effusion in patients who undergo open heart surgery. METHODS: We studied 59 patients, average age of 50 years. Twenty-six (44%) patients had undergone CABG, 25 (42%) valvar procedures and 8 (14%) different procedures. The control group were 20 patients, average age 44 years. Nine (45%) underwent CABG, 6 (30%) valvar procedures and 5 (25%) other procedures. Every patient was submitted to echocardiographic study to verify presence of pericardial effusion after operation. RESULTS: There was one patient with pericardial effusion with 8mm in the study group. Six patients showed pericardial effusion in the control group. The control group had mean drainage flow of 320 +/- 110ml and average permanence time was 45 +/- 10h. The study group had mean drainage flow of 410 +/- 122ml, the average permanence time was 46 +/- 10h. There was statistic difference between both groups when we compared the frequency of pericardial effusion. CONCLUSION: This drainage system reduces pericardial effusion comparing with the literature and causes little discomfort to the patient. The fixed rule to remove the drains did not present more discomfort to the patient and there were no complications related to its permanence.

-Rate-responsive pacemaker with an unexpected chronotropic response-. / Marcapasso responsivo com resposta cronotrópica inesperada.

The pacemaker with rate-responsiveness was a great advance in cardiac stimulation, however, the choice of the best biosensor is still object of research. A 35 year-old woman with a responsive pacemaker implanted due to a complete heart block after interventricular septal defect surgical correction was admitted. The pacemaker showed improper cronothropic response with high frequency due to biosensing malfunction. Malfunction related to muscle stimulation in the generator pocket and a high response rate. A palliative procedure was made until the end of pregnancy, by reducing the sensitivity of biosensing.

Marcapasso responsivo com resposta cronotrópica inesperada / Rate-responsive pacemaker with an unexpected chronotropic response

Os marcapassos responsivos foram um grande avanço na estimulaçäo cardíaca, contudo, a escolha de um biossensor fisiológico adequado é objeto de muito estudo. Mulher de 35 anos com marcapasso responsivo devido a bloqueio atrioventricular total (BAVT) secundário a correçäo de comunicaçäo interventricular deu entrada com insuficiência cardíaca (IC) e estimulaçäo peitoral importante na loja do marcapasso, que levou a interpretaçäo errônea, causando IC. Uma soluçäo paliativa foi tomada até o fim da gestäo, dimunuindo-se a sensibilidade do biossensor.

Penetrating heart wounds.

In 3 years, 26 patients were operated for penetrating heart wounds at our institution, the majority between 30 to 60 minutes after injury. Twenty-two patients with a possible heart wound were immediately taken to the operating room for thoracotomy. One patient initially underwent laparotomy while 2 were observed before operating-room thoracotomy. One patient underwent emergency-room thoracotomy. Three patients with no vital signs on admission died, 82.6% of the remainder survived. Stab wounds determined the best survival rate: 94%, whereas for gunshot wounds it was only 50%. Our experience at this Brazilian Trauma Center reveals that delay in reaching the hospital selected the patients, that clinical condition on arrival, method of injury (knife or gunshot), emergency room staffed with trauma surgeons and aggressive operating room treatment for penetrating heart wounds results in a remarkable survival rate. Emergency-room thoracotomy should be reserved for patients "in extremis" or when there is no operating room available.

[Fracture of endocardial electrode at the tricuspid valve level]. / Fratura de eletrodo endocárdico a nível da valva tricúspide.

Female, 72 years old, had a permanent pacemaker system with endocardial pacing lead, and developed fracture of electrode at the point of passage across the tricuspid valve with episodes of asystole.

Ultra-estrutura pulmonar e circulacao extracorporea. / Pulmonary ultrastructure and extra-corporal circulation

Com a finalidade de observar o efeito da circulacao extracorporea sobre a ultra-estrutura pulmonar, foram estudados 12 doentes submetidos a cirurgia cardiaca, com um tempo de perfusao de ate 60 minutos. Nao observamos, a microscopia eletronica, as alteracoes degenerativas classicas descritas na literatura

"Atrioseptoplastia" para a correção de comunicação interatrial do tipo seio venoso com drenagem anômala de veia pulmonar em cava superior / Atrioseptoplasty for correction of interatrial defect of the venous sinus type with anomalous drainage of pulmonary vein in the superior vena cava

Descreve-se a tecnica da "atrioseptoplastia" para a correcao da comunicacao interatrial do tipo seio venoso com drenagem anomala de veia pulmonar em cava superior.Um retalho de parede anterior do atrio direito e utilizado para fechar o defeito septal desviando, simultaneamente, o fluxo da veia pulmonar para o atrio esquerdo. Um retalho de pericardio com tamanho e forma adequados e empregado para reconstruir o atrio de pericardio com tamanho e forma adequados e empregado para reconstruir o atrio direito e a veia cava superior. Dois pacientes portadores deste tipo de anomalia congenita foram operados por esta tecnica. Os resultados imediatos foram satisfatorios. Ressalta-se a simplicidade do procedimento e a facilidade de sua execucao

O emprego da nutricao parenteral no tratamento das fistulas digestivas.Analise de 78 doentes. / Use of parenteral nutrition in the treatment of digestive fistula

Os autores apresentam 78 doentes com fistulas digestivas, sendo 19 esofagicas, 24 gastroduodenais, 14 jejuno iliais, 5 colonicas, 14 das vias biliares e 2 pancreaticas. Foi empregada a nutricao parenteral alem dos cuidados no controle das infeccoes e do local da fistula. Sobreviveram 64,2% dos pacientes e o fechamento parcial ocorreu em 8 pacientes, 2 dos quais apresentavam obstrucao distal, e outro, implante de carcinoma no trajeto fistuloso.Nenhum destes requereu reoperacao pelos pequenos debitos apresentados. O tempo variou de 5 a 90 dias, em media 21, sendo de 32 dias para os sobreviventes. A complicacao principal foi de intolerancia a glicose em doentes infectados. Os resultados obtidos permitiram a insistenica em periodos longos de nutricao parenteral, sem cirurgia associada, a nao ser em casos especiais

Efeitos da esterilizacao da dura-mater humana pelo oxido de etileno. / Effects of the sterilization of human dura-mater by ethylene oxyde

Segmentos de dura-mater, destinados a confeccao de valvas cardiacas, condicionados em glicerina a 95,5%, foram submetidos a esterilizacao pelo oxido de etileno em autoclave a duas atmosferas de pressao, por um periodo de 12 horas seguidas por 72 horas de aeracao. O oxido de etileno foi utilizado em mistura com gas carbonico na proporcao de 20% para o primeiro e 80% para o ultimo. Culturas em meios apropriados para bacterias e fungos foram negativas para controles ate 180 dias de estoque. A medida de pressao de ruptura foi utilizada para verificar eventual alteracao das caracteristicas fisicas, resultante do metodo de esterilizacao empregado. A analise dos dados obtidos, comparados aos de uma serie de controle, nao mostrou diferenca estatisticamente significante. Os autores concluem pela eficiencia do metodo empregado de esterilizacao da dura-mater humana pelo oxido de etileno e que o mesmo nao altera, de imediato, as caracteristicas fisicas do tecido. A proposicao de se adotar esse metodo, como rotina na esterilizacao de valvas cardiacas de dura-mater, deve aguardar os resultados clinicos em uma serie de pacientes em observacao