Multiresidual LC-MS analysis of plasticizers used in PVC gaskets of lids and assessment of their migration into food sauces.

Plasticizers may migrate from polyvinyl chloride (PVC) gaskets into the foodstuffs mainly by direct contact during the packaging and sterilization procedure, but also by means of occasional contacts occurring during shipment and storage. The present work reports a reliable liquid chromatography-mass spectrometry (LC-MS) method able to quantify the main plasticizers used in the PVC closure gaskets for metal lids to verify their compliance in both food contact materials and foodstuffs. The atmospheric pressure chemical ionization in the positive ion mode resulted the best performing interface for the multiresidual detection of the plasticizers taken into account, followed by selected/multiple reaction monitoring, selected ion monitoring or full scan experiments, depending on the compounds to detect. The method was single-laboratory validated, demonstrating to reach a good sensitivity, thus making possible to perform analysis without any preliminary sample purification or concentration step. It proved to be effectively applicable not only for the determination of plasticizers in PVC gaskets but also in complex food matrices. In particular, it was applied for monitoring plasticizer migration into sauces placed in contact with the lids in worst storage conditions, observing therefore their trend during the shelf-life. Copyright © 2016 John Wiley & Sons, Ltd.

Endoscopic third ventriculostomy in patients with secondary triventricular hydrocephalus from a haemorrhage or ischaemia in the posterior cranial fossa.

BACKGROUND: The aim of this project was to evaluate the efficacy of endoscopic third ventriculostomy (ETV) in the treatment of acute hydrocephalus caused by a haemorrhage or ischaemia in the posterior cranial fossa. METHODS: 21 patients who had acute triventricular hydrocephalus resulting from ischaemia in 8 cases, and from cerebellar haemorrhage in 13 cases were treated with endoscopic third ventriculostomy. This series was compared with a control group of 30 patients, with clinical neuroradiological characteristics comparable to the preceding group (18 acute post-haemorrhage hydrocephalus and 12 post-ischaemia in the posterior cranial fossa), treated by external ventricular drainage (EVD). All patients were monitored clinically and by brain computed axial tomography (CT) to measure the dimensions of the lateral and third ventricles. The criteria used to define efficacy were based on the image of the postoperative cerebral CT scan. RESULTS: No patient suffered haemorrhagic complications from surgical procedures or additional neurological deficits. There was no postoperative mortality or added morbidity. In all cases there was an improvement of intracranial hypertension. Clinical improvement was associated with a reduction of the ventricular dimensions documented by serial CT scans. CONCLUSIONS: We consider that, in selected cases, ETV can be suggested as the first choice treatment instead of the classic EVD. In the overall management of such patients, ETV has no or a very low rate of complications and allows shorter hospitalisation and earlier transfer to rehabilitative structures.

[A case of temporal arteritis presenting with sensorineural hearing loss]. / Vasculite ad esordio otorinolaringoiatrico.

The inflammatory lesions in giant cell arteritis involve the cranial branches of the arteries originating from the arch of the aorta most prominently. The vessels are thickened tender, and nodular with absent or reduced pulsation. In literature sensorineural hearing loss and Horton's arteritis are rarely associated. A case of temporal arteritis presenting with sensorineural hearing loss is described.