1.
Bioorg Med Chem Lett
; 13(18): 3067-70, 2003 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12941335
RESUMO
Novel bone-targeted 2,6,9-trisubstituted purine template-based inhibitors of Src tyrosine kinase are described. Drug design studies of known purine compounds revealed that both positions-2 and -6 were suitable for incorporating bone-seeking moieties. A variety of bone-targeting groups with different affinity to hydroxyapatite were utilized in the study. Compound 3d was determined to be a potent Src inhibitor and was quite selective against a panel of other protein kinases.