RESUMO
The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation. Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers. OBJECTIVE: Justification of the prospects of creating radioprotective agents based on compositions of plantpolyphenolic substances (PPS) and polysaccharides. MATERIAL AND METHODS: The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy. The effects ofquercetin and patulaten to the processes of reparative regeneration under conditions of X-ray irradiation andagainst the background of butadione suppression were investigated. Indicators in the study groups were compared using the Student's t-test for independent samples; the differences were considered statistically significantat p < 0.05. RESULTS: The various biological properties of quercetin, in particular, the ability to bind hydroxyl radicals, is thepotential for developing radioprotective agents based on it. At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals. With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed. At the same time, quercetin granulescaused the most expressive effect, which increased the statistically significant value of the mitotic index by 78.5 %in relation to the group of animals injected with butadion. At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds. The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically. CONCLUSIONS: The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
Assuntos
Cromonas/farmacologia , Pectinas/farmacologia , Polifenóis/farmacologia , Quercetina/farmacologia , Lesões Experimentais por Radiação/tratamento farmacológico , Protetores contra Radiação/farmacologia , Cicatrização/efeitos dos fármacos , Animais , Células Epiteliais/efeitos dos fármacos , Células Epiteliais/patologia , Células Epiteliais/efeitos da radiação , Esôfago/efeitos dos fármacos , Esôfago/patologia , Esôfago/efeitos da radiação , Masculino , Índice Mitótico , Fenilbutazona/farmacologia , Lesões Experimentais por Radiação/etiologia , Lesões Experimentais por Radiação/patologia , Ratos , Ratos Wistar , Pele/efeitos dos fármacos , Pele/patologia , Pele/efeitos da radiação , Cicatrização/fisiologia , Raios X/efeitos adversosRESUMO
A study was made of thromboplastin, antiheparin and antithrombin activity of the brain, heart and liver tissues of rats in experimental chronic alcoholization. Appreciable changes in the tissue factors of coagulation according to the dyscoagulemia type depending on the duration and gravity of alcoholic intoxication may aggravate hemostatic disorders.
Assuntos
Alcoolismo/metabolismo , Antitrombina III/fisiologia , Coagulação Sanguínea/fisiologia , Modelos Animais de Doenças , Etanol/efeitos adversos , Fator Plaquetário 4/fisiologia , Tromboplastina/fisiologia , Alcoolismo/sangue , Alcoolismo/etiologia , Animais , Coagulação Sanguínea/efeitos dos fármacos , Encéfalo/metabolismo , Etanol/administração & dosagem , Fígado/metabolismo , Miocárdio/metabolismo , RatosRESUMO
The possibility to use 0.1% quercetin solution for the treatment of inflammatory diseases of the parotid glands was studied. The effectiveness of treatment of 26 patients was estimated according to the data of clinical examination and cytologic study of the saliva. The results obtained evidence in favour of a high effectiveness of the preparation suggested.
Assuntos
Parotidite/terapia , Quercetina/administração & dosagem , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , SoluçõesRESUMO
In 49 patients with obstructive jaundice of various genesis progressive cholemic intoxication in absence of the effect from conventional detoxication therapy, the Stachyrene preparation, which contains as an effective agent the polyphenol compounds of Stachys recta L., was used. Stachyrene was administered before and after the operation. Under the influence of the preparation in the majority of patients, the more rapid normalization of the indices of homeostasis occurred. The most pronounced effect was noted in patients with obstructive jaundice of benign genesis.
Assuntos
Colestase/tratamento farmacológico , Fenóis/uso terapêutico , Polímeros/uso terapêutico , Idoso , Colestase/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cuidados Pós-Operatórios , Cuidados Pré-OperatóriosRESUMO
Wound-healing effect of quercetin granules was examined in 20 experimental animals and in 90 patients with suppurative-inflammatory diseases of the maxillofacial and cervical soft tissue. The results evidence anti-inflammatory and wound-healing effects of quercetin granules used as 20% gel.
Assuntos
Abscesso/tratamento farmacológico , Anti-Inflamatórios não Esteroides , Celulite (Flegmão)/tratamento farmacológico , Flavonoides/administração & dosagem , Doenças Maxilomandibulares/tratamento farmacológico , Linfangite/tratamento farmacológico , Quercetina/administração & dosagem , Infecção dos Ferimentos/tratamento farmacológico , Adolescente , Adulto , Idoso , Animais , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Face , Feminino , Géis , Humanos , Masculino , Pessoa de Meia-Idade , Pescoço , RatosRESUMO
Various injuries to the sciatic nerve were modelled in experiments on 60 rats and 27 dogs to study the effect of paraaminomethylbenzoic acid on its regeneration; the efficacy of amben was compared with that of other agents used widely for the treatment of injuries to nerves. It was found that amben acts on the connective tissue of the neural scar and creates favourable conditions for growth of axons from the central to the peripheral stump of the injured nerve and accelerated their maturation.
Assuntos
Regeneração Nervosa/efeitos dos fármacos , Nervo Isquiático/fisiologia , para-Aminobenzoatos , Ácido 4-Aminobenzoico/farmacologia , Potenciais de Ação/efeitos dos fármacos , Potenciais de Ação/fisiologia , Animais , Modelos Animais de Doenças , Cães , Microcirurgia , Fibras Nervosas/efeitos dos fármacos , Fibras Nervosas/fisiologia , Ratos , Nervo Isquiático/efeitos dos fármacos , Nervo Isquiático/lesões , Fatores de TempoAssuntos
Araquidonato Lipoxigenases/antagonistas & inibidores , Flavonoides/uso terapêutico , Inibidores de Lipoxigenase , Pancreatite/tratamento farmacológico , Quercetina/uso terapêutico , Doença Aguda , Adolescente , Adulto , Idoso , Animais , Ácidos Araquidônicos/metabolismo , Cães , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pancreatite/metabolismoRESUMO
The effect of drop infusions of 10% glucose solution for parenteral nutrition, in a dose of 2 g/kg, on bile secretion was studied in experiments on dogs with chronic gallbladder-duodenal fistulas. It was demonstrated that the infusion of hypertonic glucose solution inhibits bile production quantitatively and qualitatively.
Assuntos
Bile/metabolismo , Glucose/administração & dosagem , Animais , Bile/análise , Ácidos e Sais Biliares/análise , Bilirrubina/análise , Colesterol/análise , Cães , Feminino , Solução Hipertônica de Glucose , Infusões Intravenosas , MasculinoAssuntos
Bile/metabolismo , Hidrolisados de Proteína/farmacologia , Animais , Cães , Infusões ParenteraisAssuntos
Anti-Inflamatórios , Intoxicação por Tetracloreto de Carbono/tratamento farmacológico , Colagogos e Coleréticos/farmacologia , Fenóis/farmacologia , Polímeros/farmacologia , Uremia/tratamento farmacológico , Animais , Colagogos e Coleréticos/uso terapêutico , Formaldeído/antagonistas & inibidores , Inflamação/induzido quimicamente , Intoxicação por Mercúrio/tratamento farmacológico , Fenóis/uso terapêutico , Polímeros/uso terapêutico , Coelhos , Ratos , Inibidores da Tripsina/antagonistas & inibidores , Uremia/induzido quimicamenteAssuntos
Antiulcerosos/uso terapêutico , Úlcera Péptica/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Vitaminas/uso terapêutico , Animais , Avaliação Pré-Clínica de Medicamentos , Ruído/efeitos adversos , Úlcera Péptica/etiologia , Ratos , Restrição Física/efeitos adversos , Vibração/efeitos adversosAssuntos
Carvão Vegetal/uso terapêutico , Hepatopatias/terapia , Diálise Renal/métodos , Adsorção , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The authors discuss the experience of using the spheric carbon hemosorbent for extracorporal hemoperfusion of blood in 12 patients with hepatic insufficiency developed against the background of obturation of the common bile duct by a stone or tumor. Positive clinical effects of hemosorption are shown. The method is recommended for the treatment of patients with hepatic insufficiency.