RESUMO
Phenibut is a misused substance which has shown an increase in use over the past decade. Marketed as a "dietary supplement," it is not approved in the United States for use and is not regulated by the Food and Drug Administration. The substance, however, is readily available for purchase through online markets. It has a similar drug profile as alcohol, gabapentin and benzodiazepines. Clinical effects of this drug include physiologic dependence, euphoria, anxiolysis, antispasticity, sedation, and possible nootropic properties. While there are emerging new cases of managing phenibut withdrawal, no cases currently feature phenibut addiction and withdrawal management in the geriatric population. Here we discuss such a case of phenibut addiction and withdrawal in a 68-year-old male who initially began misusing phenibut to alleviate anxiety and insomnia precipitated by worsening affective disorder, sedative, hypnotic, or anxiolytic use disorder, and alcohol use disorder.
Assuntos
Transtornos Relacionados ao Uso de Substâncias , Ácido gama-Aminobutírico , Idoso , Masculino , Humanos , Ácido gama-Aminobutírico/uso terapêutico , Hipnóticos e Sedativos/efeitos adversos , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Benzodiazepinas/efeitos adversosAssuntos
Artrite Infecciosa/diagnóstico , Sacroileíte/diagnóstico por imagem , Infecções por Serratia/diagnóstico , Adulto , Antibacterianos/uso terapêutico , Artrite Infecciosa/tratamento farmacológico , Artrite Infecciosa/microbiologia , Artrite Infecciosa/fisiopatologia , Artrocentese , Ceftriaxona/uso terapêutico , Humanos , Imageamento por Ressonância Magnética , Masculino , Radiologia Intervencionista , Sacroileíte/tratamento farmacológico , Sacroileíte/microbiologia , Sacroileíte/fisiopatologia , Infecções por Serratia/tratamento farmacológico , Infecções por Serratia/microbiologia , Infecções por Serratia/fisiopatologia , Serratia marcescens , Abuso de Substâncias por Via IntravenosaRESUMO
Zymomonas mobilis subsp. mobilis is an efficient ethanol producer with application for industrial production of biofuel. To supplement existing Z. mobilis genomic resources and to facilitate genomic research, we used Oxford Nanopore and Illumina sequencing to assemble the complete genome of the beer spoilage isolate Z. mobilis subsp. mobilis strain NRRL B-1960.