Synthesis of two-dimensional MoO2 nanoplatelets and its multistep sulfurization into MoS2.

To control the growth of layered two-dimensional structures, such as transition metal dichalcogenide materials or heterostructures, understanding the growth mechanism is crucial. Here, we report the synthesis of ultra-thin MoO2 nanoplatelets through the sublimation of MoO3. Rhombus MoO2 nanoplatelets with the P21/c space group were characterized using various microscopic and spectroscopic techniques. Introducing sulfur sources into the chemical vapor deposition system also leads to the formation of monoclinic MoO2 nanoflakes due to the incomplete sulfurization of MoO3. With a gradual increase in the vapor concentration of sulfur, MoO3 undergoes stepwise reduction into MoS2/MoO2 and eventually into MoS2. Additionally, utilizing MoO2 as a precursor for Mo sources enables the formation of monolayer MoS2 single crystals. This work provides an effective approach for growing MoO2 nanoplatelets and elucidates the mechanism behind the stepwise sulfurization of MoO3.

Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8.

Alcoholic liver disease (ALD) is a growing global health concern, and its early pathogenesis includes steatosis and steatohepatitis. Inhibiting lipid accumulation and inflammation is a crucial step in relieving ALD. Evidence shows that puerarin (Pue), an isoflavone isolated from Pueraria lobata, exerts cardio-protective, neuroprotective, anti-inflammatory, antioxidant activities. However, the therapeutic potential of Pue on ALD remains unknown. In the study, both the NIAAA model and ethanol (EtOH)-induced AML-12 cell were used to explore the protective effect of Pue on alcoholic liver injury in vivo and in vitro and related mechanism. The results showed that Pue (100 mg·kg-1) attenuated EtOH-induced liver injury and inhibited the levels of SREBP-1c, TNF-α, IL-6 and IL-1ß, compared with silymarin (Sil, 100 mg·kg-1). In vitro results were consistent within vivo results. Mechanistically, Pue might suppress liver lipid accumulation and inflammation by regulating MMP8. In conclusion, Pue might be a promising clinical candidate for ALD treatment.

Interactive and Complementary Feature Selection via Fuzzy Multigranularity Uncertainty Measures.

Feature selection has been studied by many researchers using information theory to select the most informative features. Up to now, however, little attention has been paid to the interactivity and complementarity between features and their relationships. In addition, most of the approaches do not cope well with fuzzy and uncertain data and are not adaptable to the distribution characteristics of data. Therefore, to make up for these two deficiencies, a novel interactive and complementary feature selection approach based on fuzzy multineighborhood rough set model (ICFS_FmNRS) is proposed. First, fuzzy multineighborhood granules are constructed to better adapt to the data distribution. Second, feature multicorrelations (i.e., relevancy, redundancy, interactivity, and complementarity) are considered and defined comprehensively using fuzzy multigranularity uncertainty measures. Next, the features with interactivity and complementarity are mined by the forward iterative selection strategy. Finally, compared with the benchmark approaches on several datasets, the experimental results show that ICFS_FmNRS effectively improves the classification performance of feature subsets while reducing the dimension of feature space.