Fabrication of a High-Strength, Tough, Swelling-Resistant, Conductive Hydrogel via Ion Cross-Linking, Directional Freeze-Drying, and Rehydration.

Conductive hydrogels have been in huge demand in biomedical and wearable electronics. However, the application of traditional conductive hydrogels is largely limited due to their poor mechanical properties. Here, a conductive hydrogel with excellent mechanical strength and swelling resistance properties is prepared by ion cross-linking, directional freeze-drying, and rehydration. First, the acrylamide and acrylic acid are polymerized in the κ-carrageenan solution to form the hydrogel. Then, the obtained hydrogel is cross-linked with Fe3+ by soaking in ferric chloride solution. Finally, the ionic cross-linked hydrogels are reinforced by directional freeze-drying and rehydration. The resulting hydrogel has excellent tensile strength (5.67 MPa) and high toughness (7.63 MJ/m3). It is worth noting that the hydrogel also had excellent anti-swelling properties. Its mechanical strength and volume almost show no changes after soaking in deionized water for 40 days. In addition, the hydrogel exhibits good ionic conductivity (0.091 S/m), high sensitivity, and excellent stability when applied as a strain sensor. This work proposes a simple method to fabricate a conductive hydrogel with great mechanical properties and swelling resistance, which displays huge potential in varied fields.

Polysaccharide-Based Adhesive Antibacterial and Self-Healing Hydrogel for Sealing Hemostasis.

Adhesive hydrogels have been considered as one of the most ideal materials for wound dressing. However, most existing adhesive hydrogels still have disadvantages such as low mechanical properties, poor biological activity (antibacterial and hemostatic ability), and low biocompatibility, which largely limit their application. Thus, it is highly desired to prepare a hydrogel-based wound dressing with good self-healing, ideal adhesive properties, rapid hemostasis, and excellent wound infection prevention activity. In this study, a simple method was presented to prepare a PAM-Lignin-CS-Laponite-SA hydrogel for wound dressing. The obtained hydrogel displayed excellent self-healing ability and repeatable adhesive performance, benefiting from the introduction of hydrogen bonding and electrostatic interactions inside the hydrogel network. In addition, the PAM-Lignin-CS-Laponite-SA hydrogel also exhibited low cell cytotoxicity, good antibacterial activity, and outstanding hemostatic properties. In conclusion, the PAM-Lignin-CS-Laponite-SA hydrogel demonstrated good tissue adhesion, excellent self-healing ability, effective bleeding control, and good antibacterial activity to prevent wound infection, which provides a new idea for developing a multifunctional hydrogel-based tissue adhesive hemostatic dressing.

High-Strength, Conductive, Antifouling, and Antibacterial Hydrogels for Wearable Strain Sensors.

Conductive hydrogels have shown great potential in the field of flexible strain sensors. However, their application is greatly limited due to the poor antifouling and low mechanical strength. Unfortunately, it is still a challenge to improve these two distinct properties simultaneously. Herein, a hydrogel with high strength, good conductivity, and excellent antifouling and antibacterial properties was prepared through the synergistic effect of physical and chemical cross-linking. First, acrylic acid (AA), acrylamide (AM), and 2-methacryloyloxyethyl phosphorylcholine (MPC) monomers were polymerized in the presence of chitosan chains to form the hydrogel. Then, the prepared hydrogel was immersed in a ferric ion solution to further strengthen the hydrogel through ion coordination. The obtained CS-P(AM-MPC-AA0.2)-Fe0.13+ hydrogel showed outstanding tensile strength (1.03 MPa), excellent stretchability (1075%), good toughness (7.03 MJ/m3), and fatigue resistance. The CS-P(AM-MPC-AA0.2)-Fe0.13+ hydrogel also demonstrated good ion conductivity (0.42 S/m) and excellent antifouling and antibacterial properties. In addition, the strain sensor constructed by the CS-P(AM-MPC-AA0.2)-Fe0.13+ hydrogel showed high sensitivity and good stability. This work presented a facile method to construct a zwitterionic hydrogel with high-strength, conductive, antifouling, and antibacterial properties, which suggested a promising gel platform for flexible wearable sensors.