Efficacy and toxicity of lurbinectedin in subsequent systemic therapy of extensive-stage small cell lung cancer: a meta-analysis.

OBJECTIVE: This study aimed to systematically analyze the efficacy and toxicity of lurbinectedin as a second-line or subsequent treatment for extensive-stage small cell lung cancer (ES-SCLC). METHODS: Candidate studies were identified in PubMed, Embase, Cochrane Library, ClinicalTrials.gov, CNKI, and Wanfang databases up to 1 May 2024. Objective remission rate (ORR), disease control rate (DCR), duration of response (DOR), progression-free survival (PFS), overall survival (OS), and adverse events (AEs) were extracted, respectively. The efficacy and toxicity of lurbinectedin in ES-SCLC were analyzed by meta-analysis. RESULTS: Six eligible prospective studies were included in this meta-analysis, including 536 patients with ES-SCLC who received second-line or subsequent treatment. In pooled analysis, the ORR of lurbinectedin was 35% (95% confidence interval [CI] 29-41), DCR was 67% (95%CI 58-76), DOR was 5.33 months (95%CI 4.51-6.16), PFS was 3.38 months (95%CI 2.59-4.17), and OS was 7.49 months (95%CI 5.11-9.87). The incidence of AEs and severe adverse events (SAEs) was 92% (95%CI 78-100) and 37% (95%CI 19-57), respectively. The most common AEs were leukopenia, neutropenia, anemia, and thrombocytopenia, with incidences of 81% (68-91), 74% (57-88), 73% (35-98) and 57% (46-68), respectively. CONCLUSION: As a promising alternative for second-line treatment for ES-SCLC, lurbinectedin has a certain level of efficacy and a favorable safety profile. The integration of lurbinectedin with other therapeutic modalities presents an emerging area warranting further investigation.

Synergistic Effects of Ternary Microbial Self-Healing Agent Comprising Bacillus pasteurii, Saccharomyces cerevisiae, and Bacillus mucilaginosus on Self-Healing Performance in Mortar.

In order to prevent structural damage or high repair costs caused by concrete crack propagation, the use of microbial-induced CaCO3 precipitation to repair concrete cracks has been a hot topic in recent years. However, due to environmental constraints such as oxygen concentration, the width and depth of repaired cracks are seriously insufficient, which affects the further development of microbial self-healing agents. In this paper, a ternary microbial self-healing agent composed of different proportions of Bacillus pasteurii, Saccharomyces cerevisiae, and Bacillus mucilaginosus was designed, and its crack repair ability was evaluated. When the mixing ratio was 7:1:2, the cell concentration was the highest, the precipitation amount of CaCO3 was the highest, and the crystallinity of calcite crystal was the highest. Compared to the single microorganism, the mortar specimens with ternary microorganisms had the largest repair area (up to 100%) and the deepest repair depth (CaCO3 presents at 9-12 mm from the crack surface). This is because when the concrete breaks, all three microorganisms are activated by water, O2, and CO2. Saccharomyces cerevisiae and Bacillus mucilaginosus accelerated the growth of Bacillus pasteurii and more mineralized products; CaCO3 was rapidly formed and quickly filled on the crack surface. When CaCO3 seals the surface of the crack, the internal Saccharomyces cerevisiae and Bacillus mucilaginosus continue to play a role. Bacillus mucilaginosus can accelerate the dissolution of CO2 produced by the anaerobic fermentation of Saccharomyces cerevisiae and the hydrolysis of CO32-, thereby improving the repair of the crack depth direction.

Selection, Design and Immunogenicity Studies of ASFV Antigens for Subunit mRNA Cocktail Vaccines with Specific Immune Response Profiles.

Development of safe and effective subunit vaccines for controlling African Swine Fever Virus (ASFV) infection has been hampered by a lack of protective viral antigens, complex virion structures, and multiple mechanisms of infection. Here, we selected ASFV antigens based on their localization on the virion, known functions, and homologies to the subunits of the protective vaccinia virus vaccine. We also engineered viral capsid proteins for inducing optimal antibody responses and designed T cell-directed antigen for inducing broad and robust cellular immunity. The selected antigens in lipid nanoparticle-mRNA formulations were evaluated for immunogenicity in both mice and pigs with concordant results. Different antigens induced divergent immune response profiles, including the levels of IgG and T cell responses and effector functions of anti-sera. We further developed a computational approach to combine antigens into cocktails for inducing specific immune response profiles and validated candidate cocktail vaccines in mice. Our results provide a basis for further evaluating candidate subunit mRNA vaccines in challenge studies.

Ferroelectric Interfaces for Dendrite Prevention in Zinc-Ion Batteries.

Aqueous rechargeable zinc-ion batteries (ZIBs) are increasingly recognized as promising energy storage systems for mini-grid and mini-off-grid applications due to their advantageous characteristics such as high safety, affordability, and considerable theoretical capacity. However, the long-term cycling performance of ZIBs is hampered by challenges including the uncontrolled dendrite formation, the passivation, and the occurrence of the hydrogen evolution reaction (HER) on the Zn anode. In this study, enhancing ZIB performance by implementing oxide material coatings on Zn metal, serving as a physical barrier at the electrode-electrolyte interfaces to mitigate dendrite growth and suppress the HER is concentrated. Specifically, the mechanisms through which the n-type semiconductor TiO2 coated Zn anode establishes ohmic contact with Zn, and the high-dielectric BaTiO3 (BTO) coated Zn anode fosters Maxwell-Wagner polarization with ferroelectric properties, significantly inhibiting dendrite growth and side reactions, thereby resulting in a highly stable Zn anode for efficient aqueous ZIBs is explored. This advanced BTO/Zn electrode demonstrates an extended lifespan of over 700 h compared to bare Zn and TiO2/Zn anodes. Additionally, full-cell aqueous ZIBs incorporating BTO/Zn//VO2 (B) batteries exhibit superior rate capabilities, high capacity, and sustained cycle life.

Planar Zn-Ion Microcapacitors with High-Capacity Activated Carbon Anode and VO2 (B) Cathode.

The downsizing of microscale energy storage devices plays a crucial role in powering modern emerging devices. Therefore, the scientific focus on developing high-performance microdevices, balancing energy density and power density, becomes essential. In this context, we explore an advanced Microplotter technique to fabricate hybrid planar Zn-ion microcapacitors (ZIMCs) that exhibit dual charge storage characteristics, with an electrical double layer capacitor type activated carbon anode and a battery type VO2 (B) cathode, aiming to achieve energy density surpassing supercapacitors and power density exceeding batteries. Effective loading of VO2 (B) cathode electrode materials combined with activated carbon anode onto confined planar microelectrodes not only provides reversible Zn2+ storage performance but also mitigates dendrite formation. This not only results in superior charge storage performance, including areal energies of 2.34 µWh/cm2 (at 74.76 µW/cm2) and 0.94 µWh/cm2 (at 753.12 µW/cm2), exceeding performance of zinc nanoparticle anode and activated carbon cathode based ZIMCs, but also ensures stable capacity retention of 87% even after 1000 cycles and free from any unwanted dendrites. Consequently, this approach is directed toward the development of high-performance ZIMCs by exploring high-capacity materials for efficient utilization on microelectrodes and achieving maximum possible capacities within the constraints of the limited device footprint.

Advanced Porous Gold-PANI Micro-Electrodes for High-Performance On-Chip Micro-Supercapacitors.

The downsizing of microscale energy storage devices is crucial for powering modern on-chip technologies by miniaturizing electronic components. Developing high-performance microscale energy devices, such as micro-supercapacitors, is essential through processing smart electrodes for on-chip structures. In this context, we introduce porous gold (Au) interdigitated electrodes (IDEs) as current collectors for micro-supercapacitors, using polyaniline as the active material. These porous Au IDE-based symmetric micro-supercapacitors (P-SMSCs) show a remarkable enhancement in charge storage performance, with a 187% increase in areal capacitance at 2.5 mA compared to conventional flat Au IDE-based devices, despite identical active material loading times. Our P-SMSCs achieve an areal capacitance of 60 mF/cm2, a peak areal energy density of 5.44 µWh/cm2, and an areal power of 2778 µW/cm2, surpassing most reported SMSCs. This study advances high-performance SMSCs by developing highly porous microscale planar current collectors, optimizing microelectrode use, and maximizing capacity within a compact footprint.

Preparation and Properties of Lightweight Geopolymer by Bio-Based Foaming Agent.

Lightweight geopolymers have the advantages of a wide source of raw materials, chemical corrosion resistance, high mechanical strength and excellent durability, and are expected to replace traditional building insulation materials. In this paper, a green bio-based foaming agent with a small 1 h settlement distance, high average foaming multiple and low bleeding ratio was obtained by a Cetyltrimethylammonium Bromide/yeast solution. When the amount of Cetyltrimethylammonium Bromide is 0.50 wt%, the foam prepared by the yeast and Cetyltrimethylammonium Bromide solution exhibits the improved 1 h settlement distance, the large average foaming multiple, the small bleeding ratio and uniform foam size. Subsequently, a lightweight geopolymer based on metakaolin and fly ash (or silica fume) was successfully prepared by the bio-based foaming agent, and the effects of different foam content on the properties of the geopolymer, such as dry density, water absorption, thermal conductivity, compressive strength and morphology, were studied. With an increase in foam content, the dry density, thermal conductivity and compressive strength of the geopolymer gradually decrease, the water absorption increases, regardless of whether silica fume or fly ash are added. Herein, it is confirmed that the foaming agent based on yeast can be effectively used to prepare lightweight geopolymers, which can provide vast opportunities to turn into candidates for novel inorganic thermal insulation materials.

Atomically dispersed asymmetric cobalt electrocatalyst for efficient hydrogen peroxide production in neutral media.

Electrochemical hydrogen peroxide (H2O2) production (EHPP) via a two-electron oxygen reduction reaction (2e- ORR) provides a promising alternative to replace the energy-intensive anthraquinone process. M-N-C electrocatalysts, which consist of atomically dispersed transition metals and nitrogen-doped carbon, have demonstrated considerable EHPP efficiency. However, their full potential, particularly regarding the correlation between structural configurations and performances in neutral media, remains underexplored. Herein, a series of ultralow metal-loading M-N-C electrocatalysts are synthesized and investigated for the EHPP process in the neutral electrolyte. CoNCB material with the asymmetric Co-C/N/O configuration exhibits the highest EHPP activity and selectivity among various as-prepared M-N-C electrocatalyst, with an outstanding mass activity (6.1 × 105 A gCo-1 at 0.5 V vs. RHE), and a high practical H2O2 production rate (4.72 mol gcatalyst-1 h-1 cm-2). Compared with the popularly recognized square-planar symmetric Co-N4 configuration, the superiority of asymmetric Co-C/N/O configurations is elucidated by X-ray absorption fine structure spectroscopy analysis and computational studies.

Water Stability of Fibers-Enhanced Asphalt Mixtures under Static and Dynamic Damage Conditions.

Water damage is one of the major distresses of asphalt pavements. Existing methods for investigating the water stability of asphalt mixtures rely primarily on static water test methods, the tensile strength ratio (TSR) test, and the retained Marshall stability (RMS) test, which evaluate the strength and stability loss after freeze-thaw damage or hot water immersion, respectively. However, these methods do not accurately replicate the actual dynamic water damage conditions to pavement. Therefore, in this study, a variety of damage conditions, including static water conditions and dynamic water pressure conditions, were used to investigate the effects of lignin fibers (LFs), polyester fibers (PFs), and polypropylene fibers (PPFs) on the water stability of asphalt mixtures. First, three fibers-enhanced SMA gap-gradation asphalt mixtures were designed. Then, TSR and RMS were measured under traditional static water damage conditions and new dynamic water pressure damage conditions to evaluate the effect of fiber types on the water stability of asphalt mixtures. Finally, the void rate of asphalt mixtures and its changes under dynamic water damage conditions were further revealed with the help of CT scanning technique. Results showed that, among these three types of fibers, PFs-enhanced asphalt mixture exhibited excellent stability under both static and dynamic water conditions, and the CT scanning test also indicated that the PFs can significantly reduce the increase rate of voids in asphalt mixtures after dynamic water pressure damage. This study identified the potential of incorporating suitable type of fiber to enhance the performance of asphalt mixture under dynamic water pressure damage.

M-DDC: MRI based demyelinative diseases classification with U-Net segmentation and convolutional network.

Childhood demyelinative diseases classification (DDC) with brain magnetic resonance imaging (MRI) is crucial to clinical diagnosis. But few attentions have been paid to DDC in the past. How to accurately differentiate pediatric-onset neuromyelitis optica spectrum disorder (NMOSD) from acute disseminated encephalomyelitis (ADEM) based on MRI is challenging in DDC. In this paper, a novel architecture M-DDC based on joint U-Net segmentation network and deep convolutional network is developed. The U-Net segmentation can provide pixel-level structure information, that helps the lesion areas location and size estimation. The classification branch in DDC can detect the regions of interest inside MRIs, including the white matter regions where lesions appear. The performance of the proposed method is evaluated on MRIs of 201 subjects recorded from the Children's Hospital of Zhejiang University School of Medicine. The comparisons show that the proposed DDC achieves the highest accuracy of 99.19% and dice of 71.1% for ADEM and NMOSD classification and segmentation, respectively.

Hydrogenated V2O5 with Improved Optical and Electrochemical Activities for Photo-Accelerated Lithium-Ion Batteries.

Solar power represents an abundant and readily available source of renewable energy. However, its intermittent nature necessitates external energy storage solutions, which can often be expensive, bulky, and associated with energy conversion losses. This study introduces the concept of a photo-accelerated battery that seamlessly integrates energy harvesting and storage functions within a single device. In this research, a novel approach for crafting photocathodes is presented using hydrogenated vanadium pentoxide (H:V2O5) nanofibers. This method enhances optical activity, electronic conductivity, and ion diffusion rates within photo-accelerated Li-ion batteries. This study findings reveal that H:V2O5 exhibits notable improvements in specific capacity under both dark and illuminated conditions. Furthermore, it demonstrates enhanced diffusion kinetics and charge storage performance when exposed to light, as compared to pristine counterparts. This strategy of defect engineering holds great promise for the development of high-performance photocathodes in future energy storage applications.

The efficacy and toxicity of mirvetuximab soravtansine, a novel antibody-drug conjugate, in the treatment of advanced or recurrent ovarian cancer: a meta-analysis.

INTRODUCTION: This meta-analysis aims to systematically analyze the efficacy and toxicity of mirvetuximab soravtansine (MIRV) as second-line and above treatment for advanced or recurrent ovarian cancer. METHODS: Candidate studies were identified in PubMed, Embase, Cochrane Library, CNKI, and Wanfang databases up to 1 May 2023. Objective response rate (ORR), progression-free survival (PFS), the incidence of adverse events (AEs), and incidence of grade ≥ 3 AEs were extracted and calculated by meta-analysis of merging ratios or mean to describe the efficacy and toxicity of MIRV. RESULTS: Seven eligible prospective studies were included in this meta-analysis, including 605 patients with advanced ovarian cancer who received second-line or higher therapy. ORR of MIRV was 34.2% (95% confidence interval [CI] 25.0-43.5), and PFS was 5.82 months (95%CI 4.47-7.18). The overall incidence of AEs was 87.4% (95%CI 52.9-100.0) and the incidence of grade ≥ 3 AEs was 27.1% (95%CI 18.9-36.1). The most common AEs were vision blurring, nausea, and diarrhea, with incidence of 46.7% (39.6-53.8), 41.8% (34.0-49.9), and 41.3% (30.4-52.5), respectively. CONCLUSIONS: MIRV has definite efficacy and good safety as a novel choice for second-line and above treatment of advanced or recurrent FRα positive ovarian cancer. This may have promising application in patients with platinum-resistant diseases. PROSPERO REGISTRATION NUMBER: CRD42023428599.

Bio-Inspired Polyanionic Electrolytes for Highly Stable Zinc-Ion Batteries.

For zinc-ion batteries (ZIBs), the non-uniform Zn plating/stripping results in a high polarization and low Coulombic efficiency (CE), hindering the large-scale application of ZIBs. Here, inspired by biomass seaweed plants, an anionic polyelectrolyte alginate acid (SA) was used to initiate the in situ formation of the high-performance solid electrolyte interphase (SEI) layer on the Zn anode. Attribute to the anionic groups of -COO- , the affinity of Zn2+ ions to alginate acid induces a well-aligned accelerating channel for uniform plating. This SEI regulates the desolvation structure of Zn2+ and facilitates the formation of compact Zn (002) crystal planes. Even under high depth of discharge conditions (DOD), the SA-coated Zn anode still maintains a stable Zn stripping/plating behavior with a low potential difference (0.114 V). According to the classical nucleation theory, the nucleation energy for SA-coated Zn is 97 % less than that of bare Zn, resulting in a faster nucleation rate. The Zn||Cu cell assembled with the SA-coated electrode exhibits an outstanding average CE of 99.8 % over 1,400 cycles. The design is successfully demonstrated in pouch cells, where the SA-coated Zn exhibits capacity retention of 96.9 % compared to 59.1 % for bare Zn anode, even under the high cathode mass loading (>10 mg/cm2 ).

Modification and Enhancing Contribution of Fiber to Asphalt Binders and Their Corresponding Mixtures: A Study of Viscoelastic Properties.

The performance of asphalt binders and asphalt mixtures can be enhanced by the inclusion of fiber. The viscoelastic characteristics of fiber-reinforced asphalt binders and their corresponding mixtures were characterized in this study. To generate fiber-reinforced asphalt samples for dynamic shear rheometer (DSR) tests, polypropylene fibers (PPFs), polyester fibers (PFs), and lignin fibers (LFs) were added into modified asphalt with a ratio of 5wt%. Indirect tensile resilience tests were conducted on the fiber-reinforced asphalt mixture with Marshall samples, which was prepared with a 6.4% of bitumen/aggregate ratio. The addition of fiber can increase the anti-rutting performance of asphalt binders, and also reduce the anti-fatigue performance of asphalt binders to varying degrees. Viscoelastic properties of the fiber-reinforced asphalt binders are highly dependent on the shape of the used fiber. The resistance of the fiber-reinforced asphalt binders to rutting at high temperatures increases with the roughness degree of the fiber's surface morphology. PPF-reinforced asphalt binders surpass the others in terms of anti-rutting capabilities. The high-temperature deformation resistance of the PPF-reinforced asphalt mixture is stronger, whereas the low-temperature crack resistance of the PF-reinforced asphalt mixture is stronger, which can be observed from the master curve of indirect tensile resilient modulus.

Ion-Conducting Ceramic Membrane Reactors for the Conversion of Chemicals.

Ion-conducting ceramic membranes, such as mixed oxygen ionic and electronic conducting (MIEC) membranes and mixed proton-electron conducting (MPEC) membranes, have the potential for absolute selectivity for specific gases at high temperatures. By utilizing these membranes in membrane reactors, it is possible to combine reaction and separation processes into one unit, leading to a reduction in by-product formation and enabling the use of thermal effects to achieve efficient and sustainable chemical production. As a result, membrane reactors show great promise in the production of various chemicals and fuels. This paper provides an overview of recent developments in dense ceramic catalytic membrane reactors and their potential for chemical production. This review covers different types of membrane reactors and their principles, advantages, disadvantages, and key issues. The paper also discusses the configuration and design of catalytic membrane reactors. Finally, the paper offers insights into the challenges of scaling up membrane reactors from experimental stages to practical applications.

Research on Recycling of Phosphorus Tailings Powder in Open-Graded Friction Course Asphalt Concrete.

The reuse in high-value materials is one of the important resource utilization approaches of phosphorus tailings. At present, a mature technical system has been formed on the reuse of phosphorus slag in building materials, and silicon fertilizers in the extraction of yellow phosphorus. But there is a lack of research on the high-value reuse of phosphorus tailings. In order to make safe and effective utilization of phosphorus tailing resources, this research concentrated on how to solve easy agglomeration and difficult dispersion of phosphorus tailing micro-powder, when it was recycled in road asphalt. In the experimental procedure, phosphorus tailing micro-powder is treated in two methods. One method is to directly add it with different contents in asphalt to form a mortar. Dynamic shear tests were used to explore the effect of phosphorus tailing micro-powder on the high-temperature rheological properties of asphalt influence mechanism of material service behavior. The other method is to replace the mineral powder in asphalt mixture. The effect of phosphate tailing micro-powder on the water damage resistance in open-graded friction course (OGFC) asphalt mixtures was illustrated, based on the Marshall stability test and the freeze-thaw split test. The research results show that the performance indicators of the modified phosphorus tailing micro-powder meet the requirements for mineral powder in road engineering. Compared with standard OGFC asphalt mixtures, the residual stability of immersion and freeze-thaw splitting strength were improved when replace the mineral powder. The residual stability of immersion increased from 84.70% to 88.31%, and freeze-thaw splitting strength increased from 79.07% to 82.61%. The results indicate that phosphate tailing micro-powder has a certain positive effect on the water damage resistance. These performance improvements can be attributed to the larger specific surface area for phosphate tailing micro-powder than ordinary mineral powder, which can effectively adsorb asphalt and form structural asphalt. The research results are expected to support the large-scale reuse of phosphorus tailing powder in road engineering.

Fiber-Reinforced Asphalt Mixture Design on Anti-Skid Surfacing for Field Testing High-Speed Vehicles on Pavements.

Fiber can absorb asphalt binder and therefore reinforce and stabilize the asphalt mixture structure and also prevent the asphalt from the leaking, which occurs in the process of mixing and transport. In this study, three kinds of fiber (polyester fiber, polypropylene fiber, and lignin fiber) are used to evaluate the relationship between the fiber types and mechanic performance of SMA-13 fiber asphalt mixture, which is specially designed for field tests of high-speed vehicles on pavements. The micro-surface characteristics of fiber and aggregates were studied by SEM and image analysis. Marshall stability and splitting strength were used to measure the properties of the asphalt mixture. In addition, a field test, including measures for curve-section edge, curve-section center, straight-section edge, and straight-section center, was conducted to evaluate the skid resistance of the high-speed vehicles that test field pavement. The results show that the Marshall stabilities of asphalt mixture with three kinds of fibers have been improved, whereas the stability of asphalt mixture prepared by polypropylene fiber and polyester fiber particularly increased before immersion. Among the three kinds of fiber asphalt mixtures, the polyester fiber asphalt mixture has enhanced water susceptibility. Skid resistance in the field test indicated that high skid resistance and good surface-texture depth were achieved.

Differentiation of MOGAD in ADEM-like presentation children based on FLAIR MRI features.

OBJECTIVE: The differences in magnetic resonance imaging (MRI) between children with classic acute disseminated encephalomyelitis (ADEM) and myelinal oligodendrocyte glycoprotein antibody associated disease (MOGAD) with ADEM-like presentation are controversial. The purpose of this study was to investigate whether the radiological characteristics of the MRI-FLAIR sequence can predict MOGAD in children with ADEM-like presentation and to further explore its imaging differences. METHODS: We extracted 1041 radiomics features from MRI-FLAIR lesions. Then we used the redundancy analysis (Spearman correlation coefficient), significance test (student test or Mann-Whitney U test), least absolute contraction and selection operator (LASSO) to select potential predictors from the feature groups. The selected potential predictors and MOG antibody test results were used to fit the machine learning model for classification. Combined with feature selection and machine learning classifiers, the optimal model for each subgroup was derived. The resulting models have been evaluated using the receiver operator characteristic curve (ROC) at the lesion level and the model performance was evaluated at the case level using decision curve analysis. RESULTS: We retrospectively reviewed and re-diagnosed 70 ADEM-like presentation cases in our center from April 2015 to January 2020. Including 49 cases with classic ADEM and 21 cases with MOGAD. 30(43%) were female, with a median age of 5.3 years. On the four subgroups by age and gender, the area under the curve (AUC) of the optimal models were 89%, 90%, 98%, and 99%, and the MOGAD detection rates (Specificity) were 83%, 83%, 92%, and 75%, respectively. CONCLUSIONS: The machine learning model trained on radiomics features of MR-FLAIR images can effectively predict patients' MOGAD. This study provides a fast, objective, and quantifiable method for MOGAD diagnosis.

Design and Gesture Optimization of a Soft-Rigid Robotic Hand for Adaptive Grasping.

Soft robotic hands are inherently safer and more compliant in robot-environment interaction than rigid manipulators, but their flexibility and versatility still need improving. In this article, a gesture adaptive soft-rigid robotic hand is proposed. The robotic hand has three pneumatic two-segment fingers. Each finger segment is driven independently for flexible gesture adjustment to match up with different object shapes. The palm is constructed by a rigid skeleton driven by a soft pneumatic spring. It provides a firm support, large workspace, and independent force control for the fingers. Geometry model of the robotic hand is established, based on which a grasping gesture optimization algorithm is adopted. The fingers achieve optimal contact with objects by performing maximal curving similarity with the object outlines. Experiment shows that the soft-rigid robotic hand provides adaptive and reliable grasping for objects of different sizes, shapes, and materials with optimized gestures.

Highly Reversible Zinc Metal Anode in a Dilute Aqueous Electrolyte Enabled by a pH Buffer Additive.

Aqueous zinc-ion batteries have drawn increasing attention due to the intrinsic safety, cost-effectiveness and high energy density. However, parasitic reactions and non-uniform dendrite growth on the Zn anode side impede their application. Herein, a multifunctional additive, ammonium dihydrogen phosphate (NHP), is introduced to regulate uniform zinc deposition and to suppress side reactions. The results show that the NH4 + tends to be preferably absorbed on the Zn surface to form a "shielding effect" and blocks the direct contact of water with Zn. Moreover, NH4 + and (H2 PO4 )- jointly maintain pH values of the electrode-electrolyte interface. Consequently, the NHP additive enables highly reversible Zn plating/stripping behaviors in Zn//Zn and Zn//Cu cells. Furthermore, the electrochemical performances of Zn//MnO2 full cells and Zn//active carbon (AC) capacitors are improved. This work provides an efficient and general strategy for modifying Zn plating/stripping behaviors and suppressing side reactions in mild aqueous electrolyte.