Role of an acidic environment in the treatment of diabetic foot infections: A review.

Management of diabetic foot ulcers is the biggest challenge to the clinician, as conventional antibiotic therapies and local wound care have their own limitations. They are not effective for control of infections and promotion of healing because of cytotoxic effects. In view of cytotoxicity of routinely used topical antiseptic agents, this article focuses on the search of an ideal topical antiseptic agent that is safe and effective in controlling infectious agents and also in promoting the healing process. This review focuses on the use of various acids such as citric, acetic, hyaluronic, and hypochlorous acids as topical agents in diabetic foot infections. This article also focuses on the different roles of acids in the treatment of diabetic foot infections.

Using Topical Citric Acid to Treat an Infected Ulcerated Hemangioma in an Infant: A Case Study.

INTRODUCTION: Infantile hemangiomas (IHs) are the most common vascular abnormalities in children under 1 year old; most IHs involute spontaneously and do not need intervention unless a complication occurs. Ulceration and secondary infection are the most common complications. Despite appropriate conventional wound care, ulcerated IHs are difficult to heal. Although oral propranolol and topical timolol have been found to be effective in the treatment of ulcerated hemangiomas, they have been reported to have adverse effects and limitations. Citric acid has been used on pediatric patients without any reported adverse effects in the treatment of a variety of infected wounds refractory to conventional treatment modalities. Herein, the authors report the case of a large, ulcerated, infected hemangioma treated with topical application of citric acid ointment.  Case Report. A 6-month-old otherwise healthy infant who had undergone previous, unsuccessful treatment of a large, ulcerated hemangioma infected with Pseudomonas aeruginosa was treated using topical application of 3% citric acid in a petroleum jelly base once daily for 24 days. Topical application of citric acid resulted in complete healing of the ulcer in 24 applications. Conclusions. The efficacy, ease of application, and absence of notable adverse effects of using citric acid suggest it may be an effective option for the treatment of hemangiomas in children.