Social genomics, cognition, and well-being during the COVID-19 pandemic.

INTRODUCTION: Adverse psychosocial exposure is associated with increased pro-inflammatory gene expression and reduced type-1 interferon gene expression known as the conserved transcriptional response to adversity (CTRA). CTRA is not well-studied in cognitive impairment but may contribute to late-life cognitive decline. METHODS: We examined perceived stress, loneliness, well-being, and the impact of coronavirus disease 2019 (COVID-19) and the relationship to the expression of genes associated with the CTRA. Mixed-effect linear models were used to quantify associations between psychosocial variables and CTRA gene expression. RESULTS: Eudaimonic well-being (EWB) was inversely associated with CTRA gene expression in participants with both normal cognition (NC) and mild cognitive impairment (MCI). Self-reported coping strategies differed by cognitive status and variably impacted CTRA gene expression. DISCUSSION: EWB is an important correlate of stress, even in people with MCI. The prodromal cognitive decline appears to moderate the significance of coping strategies as a correlate of CTRA gene expression. Highlights: Conserved transcriptional response to adversity (CTRA) gene expression is higher with lower eudaimonic well-being.Eudaimonic well-being was important in both participants with normal cognition and those with mild cognitive impairment.Coping strategies and impact on CTRA gene expression differed by cognitive status.Loneliness in a population with relatively low loneliness scores did not impact CTRA gene expression.

Temporal orientation of positive reappraisal.

Although it is well established that positive reappraisal-changing the way one thinks about an emotional event to feel more positive about it-is an effective emotion regulation strategy, researchers have only recently begun to characterize the relative utility and effectiveness of different forms of positive reappraisal. We propose that temporal orientation-thinking about the past versus the future-may be one particularly useful characterization of positive reappraisal. In three studies, participants were instructed to use positive reappraisal to feel better about a stressor and we either measured (Studies 1 and 3) or manipulated (Study 2) the orientation of those reappraisals to the future or to the past. The findings demonstrated that people tended to use reappraisals that were more future oriented than past oriented (Studies 1 and 3). In addition, although both forms of reappraisals were effective at regulating emotion, future-oriented reappraisals were slightly more effective at increasing positive emotion (Study 2) and higher in perceived effectiveness (Study 3). Lastly, people generated reappraisals that were more oriented to the past in response to stressors that were familiar (Studies 1 and 3) and/or chronic (Study 3); however, the future orientation of their reappraisals was insensitive to the characteristics of the stressors. Our results suggest that there is a clear distinction in the utility and effectiveness of past-oriented and future-oriented forms of positive reappraisal, suggesting that this novel characterization of positive reappraisals by their temporal orientation may prove critical for more fully understanding the effectiveness of positive reappraisal for regulating emotion. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

How do people use reappraisal? An investigation of selection frequency and affective outcomes of reappraisal tactics.

Although the effects of different emotion regulation strategies are well-documented, most studies to date have focused on the selection and implementation of broad strategies, while overlooking the selection and implementation of specific tactics to enact those strategies. The present research investigated the strategy of cognitive reappraisal and the differences in selection frequency and affective outcomes that are associated with the implementation of different reappraisal tactics to enact that strategy. Participants completed a laboratory task in which they were instructed to reappraise or not to reappraise negative images and reported on their use of specific reappraisal tactics for every trial. Using established reappraisal tactic coding, we assessed how people selected from among common tactics for each image (Study 1) and all tactics (Study 2) and implemented those tactics to reappraise negative images. We compared reappraisal tactic selection and implementation when used during instructed reappraisal versus during spontaneous reappraisal, in the nonreappraise condition. Results of both studies indicate that tactics were used more often when instructed to reappraise versus when spontaneously reappraising. Participants used some tactics (e.g., reality challenge) more frequently compared to the rest of the tactics in both conditions. Negative affect was lower following instructed versus spontaneous reappraisal. Some tactics (e.g., change current circumstances) were more effective at decreasing negative affect in both conditions. Knowing which reappraisal tactics are most frequently selected, and their affective outcomes when used when prompted or spontaneously, may help us better understand how to improve people's ability to use reappraisal to achieve their emotional goals. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The Future of Immersive Mood Induction in Affective Science: Using Virtual Reality to Test Effects of Mood Context on Task Performance.

A fundamental premise of affective and clinical science is that fluctuations in mood drive meaningful changes in cognition and behavior. These theories are often tested via laboratory mood induction procedures followed by performing an established task. Despite advances in understanding the temporal dynamics of emotions, it is still unclear whether it is the enduring mood that impacts subsequent task performance. Additionally, this design requires task switching, which may limit the impact of mood and affect task performance. We suggest that virtual reality (VR) offers a more powerful, immersive alternative to traditional mood induction methods and effectively addresses these limitations because it can be used to create mood contexts that occur simultaneously with task performance. VR creates an immersive, real-world experience while benefiting from a well-controlled laboratory setting (Diniz Bernardo et al., 2021). We first summarize the literature on mood induction methodologies, including evidence that VR creates a more immersive environment, leading to mood inductions that are greater in magnitude than other methods. We then report a novel empirical study on the feasibility of utilizing VR to create a mood context that occurs simultaneously with a gold-standard emotion regulation task. Our results indicate that VR was a powerful and enduring positive mood induction tool, resulting in immediate changes in mood and greater trial-by-trial positivity ratings during the concurrent task. Portions of this study were pre-registered on August 3, 2020, on the Clinical Trials website (project citation: https://clinicaltrials.gov/ct2/show/NCT04496258). Supplementary Information: The online version contains supplementary material available at 10.1007/s42761-023-00213-1.

Resilience as the Ability to Maintain Well-Being: An Allostatic Active Inference Model.

Resilience is often characterized as the outcome of well-being maintenance despite threats to that well-being. We suggest that resilience can also be characterized as an emotional-intelligence-related ability to obtain this outcome. We formulate an allostatic active inference model that outlines the primary tools of this resilience ability as monitoring well-being, maintaining stable well-being beliefs while updating situational beliefs and flexibly prioritizing actions that are expected to lead to well-being maintenance or gathering the information needed to discern what those actions could be. This model helps to explain the role of positive emotions in resilience as well as how people high in resilience ability use regulatory flexibility in the service of maintaining well-being and provides a starting point for assessing resilience as an ability.

Falling hard, but recovering resoundingly: Age differences in stressor reactivity and recovery.

Strength and vulnerability integration (SAVI) theory (Charles, 2010) posits that age differences in emotional experiences vary based on the distance from an emotionally eliciting event. Before and after a stressor, SAVI predicts that older age is related to motivational strivings that often result in higher levels of well-being. However, during stressor exposure, age differences are predicted to be attenuated or disappear completely. The present study examined how younger (n = 85; Mage = 22.56 years) and older (n = 85; Mage = 71.05 years) adults reacted to and recovered from a cognitive stressor using repeated positive and negative emotion probes. Results showed that both age groups were negatively impacted by the stressor, and both reported an initial boost in recovery afterward. However, older adults continued to improve across the recovery period compared with younger adults. This work elucidates that older adults are significantly impacted by stress but exhibit a resounding recovery. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Social genomics, cognition, and well-being during the COVID-19 pandemic.

INTRODUCTION: Adverse psychosocial exposure is associated with increased proinflammatory gene expression and reduced type-1 interferon gene expression, a profile known as the conserved transcriptional response to adversity (CTRA). Little is known about CTRA activity in the context of cognitive impairment, although chronic inflammatory activation has been posited as one mechanism contributing to late-life cognitive decline. METHODS: We studied 171 community-dwelling older adults from the Wake Forest Alzheimer's Disease Research Center who answered questions via a telephone questionnaire battery about their perceived stress, loneliness, well-being, and impact of COVID-19 on their life, and who provided a self-collected dried blood spot sample. Of those, 148 had adequate samples for mRNA analysis, and 143 were included in the final analysis, which including participants adjudicated as having normal cognition (NC, n = 91) or mild cognitive impairment (MCI, n = 52) were included in the analysis. Mixed effect linear models were used to quantify associations between psychosocial variables and CTRA gene expression. RESULTS: In both NC and MCI groups, eudaimonic well-being (typically associated with a sense of purpose) was inversely associated with CTRA gene expression whereas hedonic well-being (typically associated with pleasure seeking) was positively associated. In participants with NC, coping through social support was associated with lower CTRA gene expression, whereas coping by distraction and reframing was associated with higher CTRA gene expression. CTRA gene expression was not related to coping strategies for participants with MCI, or to either loneliness or perceived stress in either group. DISCUSSION: Eudaimonic and hedonic well-being remain important correlates of molecular markers of stress, even in people with MCI. However, prodromal cognitive decline appears to moderate the significance of coping strategies as a correlate of CTRA gene expression. These results suggest that MCI can selectively alter biobehavioral interactions in ways that could potentially affect the rate of future cognitive decline and may serve as targets for future intervention efforts.

Positive distraction in daily activities as a predictor of good coping: A "day in the life" during the COVID-19 pandemic.

Introduction: The early part of the coronavirus pandemic (COVID-19) was a chronic stressor that led to decreased life satisfaction, increased psychopathology, and decreased social interaction, making it important to study coping strategies that stimulate increases in emotional well-being. Previous research has demonstrated that disengagement coping may be beneficial in scenarios where engagement coping is too difficult or not possible. We hypothesized that disengagement coping would be related to good emotional well-being (high positive emotions and/or perceived control, lower negative emotions and/or stress), with distraction (taking a break from a stressor) related to better emotional well-being than is avoidance (avoiding thoughts and feelings associated with a stressor). Methods: Using a daily reconstruction method that represents a "day in the life" of people in the United States during the early stages of the COVID-19 pandemic, we assessed people's (N = 329) activities, their intention to distract from or avoid the stressor during these activities, emotions, and thoughts about and motivation to deal with COVID. Results: Between-subjects' analyses revealed that habitual distraction did not predict any outcomes, while habitual avoidance related to poorer emotional well-being. Within-subject analyses, however, demonstrated that engaging in distraction (and to a smaller extent, avoidance) was associated with better concurrent emotional well-being and less thinking about COVID. Furthermore, the intent to distract/avoid was more reliable in predicting emotional outcomes than was the activity type. Conclusion: These findings suggest that disengagement from stress can be an adaptive coping behavior during global pandemics and possibly other chronic stressors with similar attributes.

Coping with COVID-19: the efficacy of disengagement for coping with the chronic stress of a pandemic.

BACKGROUND: The COVID-19 pandemic was a novel chronic stressor that necessitated figuring out how to cope with it. We hypothesized that disengagement coping - coping with a stressor by disengaging from it - would be effective because the pandemic featured heightened uncertainty and enduring intensity. DESIGN: We assessed the disengagement strategies of distraction - taking a break from a stressor - and avoidance - avoiding thoughts and feelings associated with a stressor - and emotional well-being outcomes (positive/negative emotions, stress) in three waves one week apart (305 participants completed all three waves). RESULTS: Distraction was one of the most frequently endorsed coping strategies. The results of multi-level models and cross-lagged panel models showed that participants who used distraction habitually experienced better emotional well-being overall and that using distraction led to better emotional well-being that week, but did not predict increases in well-being from one week to the next. Those who used avoidance also experienced better emotional well-being that week, but habitual use of avoidance was associated with worse emotional well-being overall. CONCLUSIONS: These findings suggest that in the midst of chronic stressors like this pandemic, the disengagement coping strategy of distraction is popular and effective for temporarily improving people's well-being.

What Parts of Reappraisal Make Us Feel Better? Dissociating the Generation of Reappraisals from Their Implementation.

Although reappraisal has been shown to be a highly successfully emotion regulation strategy, it requires several sequential steps, and it is still unclear when in the reappraisal process emotion changes. We experimentally dissociated the generation of reappraisals from their implementation and hypothesized that the biggest emotional effects would occur during implementation. In Study 1, participants (N = 106) saw a negative image and generated either just positive reappraisals (GEN ++) or positive and negative reappraisals (GEN +-). They then saw the image again and implemented either their positive reappraisals (for the GEN ++ and half of the GEN +- trials) or negative reappraisals (for the other half of GEN +- trials). Although there were small and significant changes in emotion when generating reappraisals, the robust changes in emotion that are typically observed during reappraisal occurred during implementation. In Study 2 (N = 130), we directly replicated the findings from Study 1 and demonstrated that this small emotional effect from just generating reappraisals was not due to discounting the forthcoming implementation goal. In summary, for the first time, we successfully dissociated reappraisal generation from implementation and show that the biggest emotional effects occur during implementation. We discuss the implications of these findings for understanding emotion regulation, the neural underpinnings of reappraisal, and the conditions for reappraisal success in clinical contexts. Supplementary Information: The online version contains supplementary material available at 10.1007/s42761-022-00129-2.

Anxiety and initial value dependence in startle habituation.

Studies suggest that deficits in startle reflex habituation occur in trait and clinical anxiety. Measures of habituation are affected by the magnitude of the initial response, with larger initial responses predicting a steeper decline in response over repeated trials. This relationship between initial value and change, commonly called the Law of Initial Value or initial value dependence (IVD), has been partialled out as a covariate in habituation research, but variation in IVD may be informative in itself, reflecting differences in physiological reactivity. The present study explored how trait anxiety and contextual anxiety relate to habituation kinetics of the startle eyeblink response: initial value, linear habituation slope, and the relationship between them (IVD). Participants (n = 31; 15 Control, 16 Contextual Anxiety [CA]) were exposed to two blocks of acoustic startle stimuli, and CA participants were warned that they may receive an electrical shock to the wrist during block 2. Trait anxiety did not predict habituation slope, but it did predict a weaker IVD relationship, meaning that high initial startle magnitude was less predictive of a steep response decline in trait-anxious subjects. Meanwhile, CA did not impact startle habituation or IVD. The results suggest that individual differences in trait anxiety are related to the relationship between initial physiological response magnitude and subsequent change in response. IVD in startle habituation may thus serve as a better biomarker of healthy emotional responding than startle habituation per se.

Comparing the affective and social effects of positive reappraisal and minimising reappraisal.

Negative interpersonal events, such as close relationship conflicts, can threaten one's affective and social well-being. To improve affect and to maintain valuable relationships, individuals could select different reappraisal tactics. One could use positive reappraisal to find potential benefits of the event (e.g. "This conflict helps our relationship grow."), or use minimising reappraisal to decrease the perceived impact of event (e.g. "This is no big deal."). These two tactics target distinct appraisal dimensions: valence versus significance. We investigated whether these two reappraisals would show similar or different profiles of affective and social effects in the context of close relationship conflicts. Study 1 was based on a sample of 90 Chinese younger adults. Study 2 was based on a sample of 237 American adults (156 MTurk workers and 81 undergraduates combined). Across two studies, both reappraisals effectively improved affect in response to a recalled conflict. Minimising reappraisal group showed significantly increased affect and relationship satisfaction (Study 1&2), but decreased conflict resolution motivation (Study 2) across time. Positive reappraisal group, on the other hand, showed less pronounced increases in positive affect but increased conflict resolution self-efficacy across time (Study 1&2). We discuss these findings by highlighting within-reappraisal variation and potential trade-offs in pursuing affective and social regulation goals.

Affect labelling increases the intensity of positive emotions.

Although affect labelling has been widely reported to decrease negative emotions, it is less clear whether affect labelling also decreases positive emotions. In four studies, we explored how affect labelling (choosing the emotion that best corresponds with the image), content labelling (choosing the word that best corresponds with the content of the image), and simply viewing images influence positive and negative emotions. Labelling positive emotions led participants to report higher positive emotional intensity than did content labelling or just viewing the image (Study 1, N = 49), and this effect persisted regardless of whether they labelled emotions during or after the image (Study 2, N = 116), rated the intensity or positivity of their emotions (Study 3, N = 120), or rated their emotions after a delay or no delay (Study 4, N = 120). Surprisingly, we did not replicate the previous findings on affect labelling and negative emotion, instead showing that content labelling of negative emotional images tended to be the most consistent predictor of decreased negative emotions. Our results challenge the formulation that affect labelling leads to the automatic downregulation of emotions and instead suggest that it might be an effective mechanism in the upregulation of positive emotions.

Coping With COVID-19: The Benefits of Anticipating Future Positive Events and Maintaining Optimism.

In early 2020, the COVID-19 pandemic forced a large portion of the world into quarantine, leading to an extensive period of stress making it necessary to explore regulatory techniques that are effective at stimulating long-lasting positive emotion. Previous research has demonstrated that anticipating positive events produces increases in positive emotion during discrete stressors. We hypothesized that state and trait positive anticipation during the COVID-19 pandemic would be associated with increased positive emotions. We assessed how often participants thought about a future positive/negative/neutral event, activity, or goal through a daily reconstruction method that represented a "day in the life" of people in the United States during the early stages of the COVID-19 pandemic. The results of multi-level modeling and mediational analyses demonstrated that higher optimism, one form of trait positive anticipation, was related to higher state positive anticipation, which was in turn related to higher positive emotions during the current episode, which persisted to the next episode. In addition, both optimism and state positive anticipation were related to adaptive responses to the pandemic. These findings suggest that anticipation of future emotional experiences and hopefulness for the future can be a powerful predictor of positive emotions during global pandemics and perhaps other similar chronic stressors.

Adaptive and maladaptive forms of disengagement coping in caregivers of children with chronic illnesses.

Caregivers of children with chronic illnesses experience elevated stress and reduced self-care. Although self-care can be beneficial, it is a form of disengagement coping, disengaging from the stressor to try and feel better, which has been characterized as a maladaptive coping strategy. In this study, we test the formulation that avoidance, avoiding the stressor and any thoughts related to it, is a maladaptive disengagement coping strategy, whereas distraction, taking a break from the stressor to do something pleasant, is an adaptive disengagement coping strategy. We assessed these strategies as well as psychosocial outcomes and trait predictors in caregivers of children with chronic illnesses. Results showed that those high in avoidance coping reported lower well-being, higher depression and higher stress. Alternatively, when controlling for avoidance, those high in distraction reported higher well-being, lower depression and lower stress. In addition, distraction exhibited strong relationships to increased positive emotions during caregiving situations and was associated with positive personality traits. These results suggest that not all disengagement coping strategies are equal; although avoidance may be a maladaptive strategy, distraction can be an effective positive emotional strategy for coping with the chronic stress of caregiving for a child with a chronic illness.

Reactive, Agentic, Apathetic, or Challenged? Aging, Emotion, and Coping During the COVID-19 Pandemic.

BACKGROUND AND OBJECTIVES: Advanced age is generally associated with improved emotional well-being, but the coronavirus 2019 pandemic unleashed a global stressor that gravely threatened the physical well-being and ostensibly challenged the emotional well-being of older adults disproportionately. The current study investigated differences in emotional experiences and coping strategies between younger and older adults during the pandemic, and whether these differences were accounted for by age differences in appraisal of the pandemic. RESEARCH DESIGN AND METHODS: We asked younger (n = 181) and older (n = 176) adult participants to report their stress, appraisals of the pandemic, emotions, and the ways in which they were coping with the pandemic. RESULTS: Results indicated that older adults experienced less stress and less negative affect and used greater problem-focused coping and less avoidant coping in response to the pandemic than younger adults. Furthermore, age differences in affect and coping were partially accounted for by age differences in appraisals of the pandemic. DISCUSSION AND IMPLICATIONS: Despite their objectively higher risk of illness and death due to the pandemic, older adults experienced less negative affect and used more agentic coping strategies than younger adults.

Not all disengagement coping strategies are created equal: positive distraction, but not avoidance, can be an adaptive coping strategy for chronic life stressors.

Background: Positive distraction involves distracting oneself from a stressor by thinking about or engaging in activities that induce positive emotion. We hypothesized that although it is a disengagement coping strategy, which have been historically viewed as maladaptive (e.g., avoidance), positive distraction can be an adaptive version that predicts positive outcomes. Design: To test this hypothesis, we developed a scale to measure positive and neutral distraction (distracting oneself by engaging in daily activities) in response to chronic stressors in 3 samples (MTurk1, N = 206; undergraduate, N = 376; MTurk2, N = 200). We then correlated the use of these strategies with outcomes in these samples and another undergraduate sample (N = 370). Results: Exploratory SEM confirmed that the scale consists of two factors corresponding to positive and neutral distraction, which were positively correlated with avoidance. However, unlike avoidance, positive distraction (and to a lesser degree neutral distraction) was related to positive outcomes such as higher well-being and positive emotions, and fewer depressive symptoms especially when controlling for avoidance. Conclusions: Our results suggest that positive distraction can be an adaptive disengagement coping strategy for chronic stressors when controlling for avoidance and should be incorporated into coping studies and interventions.

The roles of positive emotion in the regulation of emotional responses to negative events.

Although research has shown that positive emotions (PEs) can help people cope with negative events, there is not yet a systematic framework for understanding how and when they might do so. In this article, I propose such a framework by suggesting that PEs can play 3 roles when people attempt to regulate their emotional response to negative events. First, PEs may serve as the ultimate target of emotion regulation (ER) such that people attempt to feel better by regulating their PEs regardless of whether they also regulate their negative emotions. Second, PEs may serve as a mediator of ER such that people regulate their PEs in order to satisfy their ultimate goal of regulating their negative emotions. Third, PEs may serve as a moderator of ER such that incidental PEs (those occurring from some other source besides ER) may moderate people's ability to regulate positive or negative emotions. I also discuss how to determine what roles that PEs are playing in a given instance of ER, how PEs may sometimes not help ER, and how this framework contributes to the burgeoning literature on regulatory flexibility by providing different roles of PEs in ER that may be more or less effective for different people and circumstances. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

The Role of Heart Rate Variability in Mindfulness-Based Pain Relief.

Mindfulness meditation is a self-regulatory practice premised on sustaining nonreactive awareness of arising sensory events that reliably reduces pain. Yet, the specific analgesic mechanisms supporting mindfulness have not been comprehensively disentangled from the potential nonspecific factors supporting this technique. Increased parasympathetic nervous system (PNS) activity is associated with pain relief corresponding to a number of cognitive manipulations. However, the relationship between the PNS and mindfulness-based pain attenuation remains unknown. The primary objective of the present study was to determine the role of high-frequency heart rate variability (HF HRV), a marker of PNS activity, during mindfulness-based pain relief as compared to a validated, sham-mindfulness meditation technique that served as a breathing-based control. Sixty-two healthy volunteers (31 females; 31 males) were randomized to a 4-session (25 min/session) mindfulness or sham-mindfulness training regimen. Before and after each group's respective training, participants were administered noxious (49°C) and innocuous (35°C) heat to the right calf. HF HRV and respiration rate were recorded during thermal stimulation and pain intensity and unpleasantness ratings were collected after each stimulation series. The primary analysis revealed that during mindfulness meditation, higher HF HRV was more strongly associated with lower pain unpleasantness ratings when compared to sham-mindfulness meditation (B = -.82, P = .04). This finding is in line with the prediction that mindfulness-based meditation engages distinct mechanisms from sham-mindfulness meditation to reduce pain. However, the same prediction was not confirmed for pain intensity ratings (B = -.41). Secondary analyses determined that mindfulness and sham-mindfulness meditation similarly reduced pain ratings, decreased respiration rate, and increased HF HRV (between group ps < .05). More mechanistic work is needed to reliably determine the role of parasympathetic activation in mindfulness-based pain relief as compared to other meditative techniques. Perspective: Mindfulness has been shown to engage multiple mechanisms to reduce pain. The present study extends on this work to show that higher HRV is associated with mindfulness-induced reductions in pain unpleasantness, but not pain intensity ratings, when compared to sham-mindfulness meditation. These findings warrant further investigation into the mechanisms engaged by mindfulness as compared to placebo.