What is the current practice for managing patients with chronic limb-threatening ischaemia in vascular surgery services? A survey of UK vascular surgeons.

INTRODUCTION: The Vascular Society of Great Britain and Ireland (VSGBI) Peripheral Arterial Disease Quality Improvement Framework (PAD QIF) stipulates targets for managing patients with chronic limb-threatening ischaemia (CLTI); however, it is unknown whether these are achievable. This survey aims to evaluate contemporary practice for managing CLTI in the UK. METHODS: A questionnaire was developed in conjunction with the VSGBI to survey the management of CLTI and canvass opinions on the PAD QIF. The survey was distributed to all consultant members of the VSGBI and through a targeted social media campaign. RESULTS: Forty-seven consultant vascular surgeons based at 36 arterial centres across the UK responded (response rate from arterial centres = 46%). Only 14.3% of centres provided outpatient consultation within the target of seven days from referral, with only one centre providing revascularisation within the target of seven days from consultation. For inpatient management, 31.6% provided surgical and 23.8% endovascular revascularisation within the target of three days from assessment. While 60% of participants believe the PAD QIF's 5-day 'admitted care' pathway is achievable, only 28.6% thought the 14-day 'non-admitted care' pathway was feasible. Challenges to meeting these targets include the availability of theatre space and angiography lists, and availability of outpatient appointments for patient assessment. CONCLUSIONS: The opinion of UK vascular surgeons indicates that achieving the targets of the PAD QIF represents a major challenge based upon current services. Adapting existing services with a greater focus on providing an 'urgent' model of care may help to potentially overcome these challenges.

Delayed discharges at a major arterial centre: a 4-month cross-sectional study at a single specialist vascular surgery ward.

OBJECTIVES: Delayed discharges are a significant problem for the National Health Service. The objectives of this study were to determine the prevalence and impact of delayed discharge at a single specialist vascular surgery ward. DESIGN: A cross-sectional observational study. SETTING: A single specialist vascular unit in the UK during a 4-month study period (01/09/2014-31/12/2014). PARTICIPANTS: All patients admitted to the ward during the study period were included. Patients spending ≥1 night on the ward once declared medically fit for discharge (MFFD) were prospectively identified and data prospectively collected. All other patients were identified retrospectively with data collected retrospectively from electronic records. OUTCOME MEASURES: Primary outcome was number of patients experiencing delayed discharge. Secondary outcome measures were length of stay, length of delay and cost of delay. RESULTS: There were 268 admissions with a total length of stay (LoS) of 2776 days. 57 admissions (21.3%) experienced delayed discharges with a total 535 excess bed days (19.3% total LoS) once MFFD. Unplanned admission (relative risk 7.3 (95% CI 2.7 to 20.0; p<0.001)) and index amputation (relative risk 9.2 (95% CI 3.8 to 22.0; p<0.001)) were associated with increased risk of delayed discharge. There were significant differences in the length of delay by the reason for the delay (p=0.01). Delay due to the provision of social services and inpatient rehabilitation were associated with longer length of delay (post hoc analysis). Age was not independently associated with either increased risk of delayed discharge or length of delay.The total estimated cost of delayed discharges during the study period was £146 055. CONCLUSIONS: A significant number of vascular patients experience delayed discharge. MFFD vascular patients occupy a high proportion of vascular beds at considerable financial cost. Unplanned admissions, amputees and those delayed due to social services contributed most to delays. Closer integration with community health and social care providers may reduce delays.

Evidence for endovascular aneurysm repair in patients with highly angulated neck anatomy.

Patients with highly angulated neck anatomy may account for up to a fifth of all patients treated by endovascular repair. However there is evidence that these patients have worse early and long-term outcomes, including sac expansion. This review explores the evidence supporting the use of endovascular repair in the setting of severe neck angulation, with particular emphasis on new technology with devices that have expanded the anatomical criteria for endovascular aneurysm repair such as the Lombard Aorfix and Medtronic Endurant endografts.

Outcome and safety of Aorfix™ stent graft in highly angulated necks - a prospective observational study (arbiter 2).

OBJECTIVES: Severe neck angulation is associated with poor outcome following endovascular aneurysm repair. The aim was to study the safety and early outcome of patients with infrarenal aortic aneurysms with severe neck angulation (60-90°) treated with the Aorfix™ endovascular stent graft. DESIGN/METHODS: This was a non-randomized prospective observational study of 30 patients with infra-renal abdominal aortic aneurysms with highly angulated necks. Outcomes were primary technical success, 30 day and short term (30 days-6 months) clinical success and other patient morbidity at 30 days. RESULTS: Median neck angulation was 81.2°. Initial technical success was 93.3% (n = 28) with 2 stents deployed too low. Intra-operatively 3 patients initially had type I endoleaks, but all were resolved by ballooning. 30 day clinical success was 96.7%: there were no type I or type III endoleaks observed, and no reports of graft thrombosis or migration. Early clinical failure was accounted for by one perioperative death (3% mortality). No aneurysm-related interventions were required during follow-up. At 6 months two patients were reported as having type I endoleaks, although both sacs have reduced in size. Neither has required intervention. No patient has died due to aneurysm rupture or required removal of the endograft. CONCLUSION: The results of this study support the continued application of the Aorfix™ graft to the highly angulated neck.

Use of the AorfixTM stent graft in patients with tortuous iliac anatomy.

AIM: Iliac limb occlusion following endovascular repair (EVAR) may result in limb threatening acute ischemia. The incidence is reported at up to 10% and is known to be influenced by iliac angulation and kinking of the stent graft. The aim of this study was to evaluate the performance of the AorfixTM graft in tortuous iliac anatomy and examine the impact of the graft on the rate of iliac limb thrombosis following EVAR in a single UK centre METHODS: We performed a retrospective review of all EVAR performed from May 1998 to May 2010. From November 2007, patients with highly angulated iliac anatomy were treated with the AorfixTM(Lombard) stent graft, or when a ZenithTM(Cook) main body was chosen, the AorfixTM iliac limbs were used with the ZenithTM(Cook) device. We compared the rate of iliac limb occlusions before (group 1) and after (group 2) the adoption of this policy. RESULTS: Two hundred and sixty seven patients underwent EVAR (group 1 n=129; group 2 n=138). In group 1, eight patients had a unilateral iliac limb occlusion (6.2%). Six of the patients had >90 degrees iliac angulation, one had an unrecognised limb stenosis, and one patient had the stent landed in the external iliac. In group 2 there were no limb occlusions. Of the 138 patients, 25 had iliac angulation of >90 degrees . Of these 25, eighteen were treated with the AorfixTM stent graft system because of iliac angulation, and 7 were treated with AorfixTM legs and ZenithTM bodies. CONCLUSION: The rate of early iliac limb occlusion following EVAR in patients with angulated iliac anatomy can be substantially reduced by using the flexible Aorfix stent graft system.

Return to work following knee arthroplasty.

A retrospective study of a consecutive cohort of 109 patients, under the age of 60, who had either a Patellofemoral replacement (PFR), Unicompartmental replacement (UKR) or a Total knee replacement (TKR). They were operated on by two senior surgeons between 2002 and 2006 at the Avon Orthopaedic Centre in Bristol. The aim of this study was to look at the effect of knee replacement on the employment status of this group of patients. Data were collected from patient's hospital records and a questionnaire regarding occupational status was sent postoperatively to the patients. Statistical analysis showed that our groups were similar which meant that further comparison between them was valid. Eighty-two percent of the patients who were working prior to surgery and who had either a TKR or UKR were able to return to work postoperatively. Only 54% of those who had a PFR were able to return to work and this was statistically significant when compared with patients in the other two groups p=0.047. The median time for return to work postoperatively for the study population was 12 weeks. Those in the PFR group took significantly longer to do so (20 weeks) compared to those who had either a UKR (11 weeks) or TKR (12 weeks) p=0.01. Patient's subjective opinion as to their ability to work following knee arthroplasty was worse in the PFR group p=0.049. This is the first study to compare employment status following Patellofemoral, Unicompartmental knee and Total Knee Replacement. TKR and UKR are effective in returning patients under 60 years old to active employment and this is typically 3 months following surgery. Patients who had a PFR did not experience the same benefits in terms of numbers returning to work, time to do so and their subjective opinion as to their ability to cope with normal duties.

Antigen receptor V-segment usage in mucosal T cells.

In the accepted model of lymphocyte intestinal homing, naïve T cells recirculate via organized lymphoid tissues, whilst induced effector/memory cells home to the intestinal mucosa. In order to assess the T-cell-receptor repertoire in the intestine and gut-associated lymphoid tissue (GALT), spectratyping was performed on the proximal and the distal intestine, spleen and mesenteric lymph node tissue from six PVG rats. The products were analysed with an automated sequencer and statistical analyses were performed with hierarchical cluster analysis. This demonstrated the presence of a restricted T-cell repertoire in the small intestine compared with that in the mesenteric lymph nodes and the spleen. It also demonstrated marked differences in repertoire between individual, fully inbred rats maintained under apparently identical conditions in the same cage and fed identical diets. In addition, this work demonstrated marked differences between repertoires in the proximal and the distal intestine. Such marked differences are likely to reflect the end result of increasing divergence over time produced by relatively subtle effects of environment and antigenic load. Equally, marked differences in repertoire between small intestinal segments within individual rats indicate selective recruitment or retention of specific clones, presumably antigen-driven.

The progression of arthritis following lateral unicompartmental knee replacement.

In order to aid patient selection we have analysed the radiological progression of arthritis in the retained compartments following lateral unicompartmental knee replacement (UKR). Patients undergoing lateral UKR (St Georg Sled, Waldemar Link) between 1988 and 1999 were assessed. Radiographs taken post-operatively within 8 weeks and at 5 years were assessed. OA was classified using both the Altman and Ahlbach scoring systems. Identifying information on each radiograph was obscured so that the observer was blinded. Each radiograph was reviewed twice to assess intra-observer variability. Patients were assessed clinically using the Bristol Knee Score (BKS) at 1 and 5 years post-operation. Reproducibility for the Ahlbach systems was shown to be very good (kappa = 0.86) and the Altman moderate (kappa = 0.41). Thirty-two lateral UKRs were assessed at 5 years. Six out of 32 of the knees assessed showed definite progression of OA on the Ahlbäch score in the retained medial compartment and 11 out of 32 on the Altman. There was a statistically significant increase in the grade of OA, as assessed by both systems, at 5 years as compared to the post-operative radiograph (p < 0.001). The definite progression group had a mean BKS 10 points lower at 5 years. Six patients required revision to TKR for progression of arthritis in the retained compartments. Lateral compartment UKR can be a very successful procedure, but there is a greater rate of progression of arthritis in the retained medial compartment than following medial UKR.

Arthritis progression after patellofemoral joint replacement.

Progressive symptomatic tibiofemoral osteoarthritis (OA) following patellofemoral joint replacement (PFJR) may necessitate revision to total knee arthroplasty. This study was designed to quantify this problem in a prospective series of 103 consecutive patients who underwent PFJRs undertaken at our institution. At a mean follow-up of 7.1 years (66-102 months), 14 knees (14%) have been revised, 12 of those (12%) because of the development of symptomatic tibiofemoral OA, with a mean time to revision of 55 months (range 14 to 95 months). Available radiographs of the 89 unrevised knees were subject to blinded and randomised assessment by two observers. Postoperative AP knee radiographs were scored to assess for tibiofemoral OA progression, with definite progression seen in a median of 7% of medial compartments but 0% of lateral compartments, over a mean period of 51 months. Sulcus angles on preoperative 30 degrees skyline radiographs were measured to assess for trochlear dysplasia. Seventeen percent of the knees without preoperative trochlear dysplasia have been revised for progression of tibiofemoral OA, compared to none of the knees with preoperative trochlear dysplasia. Furthermore, in the unrevised knees, statistically significantly more radiographic progression of tibiofemoral OA was seen in those without preoperative trochlear dysplasia (p = 0.01). Our results suggest that progressive tibiofemoral OA following PFJR is an important cause of failure, but it is seen significantly less frequently when the patellofemoral arthritis is secondary to dysplasia of the femoral trochlea, suggesting that these patients are the ideal candidates for PFJR.

From meeting presentation to peer-review publication--a UK review.

INTRODUCTION: Annual academic surgical meetings provide a forum for the discussion of research. For the wide-spread dissemination of this information, peer-reviewed publication is required. The aim of this study was to compare the amount of presentations which go on to publication from 4 UK-based surgical meetings. MATERIALS AND METHODS: We determined whether a presentation had led to a successful publication using PubMed, a median of 28 months following each meeting. We compared the ASGBI publication rate with the meetings of the Vascular Surgical Society (VSSGBI), the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Transplantation Society (BTS). We also compared the median impact factor of journals used. RESULTS: The ASGBI and BTS had a similar rate of presentations resulting in publication, with 35% and 36% at 2 years, respectively. The VSS had a significantly greater proportion of presentations resulting in publication (54% at 2 years; P = 0.004), whilst the ACPGBI had significant fewer (24% at 2 years; P = 0.006). There was no difference in the median impact factors of the journals used between the meetings (Kruskal Wallis P = 0.883). CONCLUSIONS: There is a significant variation between meetings in terms of turning presentations into publications. However, the majority of abstracts have still not been fully published within 2 years of presentation at the meeting.

Intestinal adaptation after massive intestinal resection.

Patients with short bowel syndrome require long term parenteral nutrition support. However, after massive intestinal resection the intestine undergoes adaptation and nutritional autonomy may be obtained. Given that the complications of parenteral nutrition may be life threatening or result in treatment failure and the need for intestinal transplantation, a more attractive option is to wean patients off nutrition support by optimising the adaptive process. The article examines the evidence that after extensive small bowel resection adaptation occurs in humans and focuses on the factors that influence adaptation and the strategies that have been used to optimise this process. The review is based on an English language Medline search with secondary references obtained from key articles. There is evidence that adaptation occurs in humans. Adaptation is a complex process that results in response to nutrient and non-nutrient stimuli. Successful and reproducible strategies to improve adaptation remain elusive despite an abundance of experimental data. Nevertheless given the low patient survival and quality of life associated with other treatments for irreversible intestinal failure it is imperative that clinical research continues into the optimisation of the adaptation.

Informed consent in renal transplantation.

PURPOSE: This study was performed to assess how well completed the new consent forms are for patients undergoing renal transplantation. METHODOLOGY: 100 patients were randomly selected from the 160 who had a renal transplantation, at a single centre in the UK, over an 18 month period. The notes were located and the consent forms scrutinised. FINDINGS: Seven sets of notes could not be traced and 10 did not contain a relevant consent form. Forty eight per cent of completed forms mentioned the source of organ while 8% mentioned on which side the operation was to be performed. Twelve risks and complications were identified as being relevant to this procedure but no single form mentioned all 12. In most cases a senior member of the surgical team obtained consent. IMPLICATIONS: The demonstrated variability in the amount of detail on consent forms lends weight to the call for the use of procedure specific forms. While such variability does not necessarily equate with not gaining valid, informed consent, this form, at present, serves as the only record of what has been discussed with the patient. These findings should encourage all surgeons to complete the forms themselves, be as detailed as possible, and ensure that the form is filed in the patients' notes.

Radiological changes ten years after St. Georg Sled unicompartmental knee replacement.

Failure of a unicompartmental knee replacement (UKR) may be caused by progressive osteoarthritis of the knee and/or failure of the prosthesis. We have examined the fate of the other compartments of the knee by radiological assessment 10 years after operation. A total of 50 UKRs were performed on 45 carefully selected patients between 1989 and 1992. Fifteen patients died, two patients were lost to follow-up and two knees were revised. Standard long-leg weight-bearing anteroposterior views of the knee and skyline views of the patellofemoral joint were taken pre-operatively and at 8 months and 10 years after operation. The radiographs of the remaining 30 knees were reviewed three times by blind and randomized assessment to measure the progression of osteoarthritis within the joints. Two knees showed evidence of progression of osteoarthritis within the patellofemoral joint and three knees showed some progression of the opposite tibiofemoral compartment--but only on one of the radiological grading systems used for assessment. It is concluded that progression of arthritis in the unreplaced compartments is not a significant problem after fixed bearing UKR.

The impact of training on outcomes in primary vascular access surgery.

BACKGROUND: There is evidence that the outcome of arteriovenous fistula surgery is dependent on the surgeon performing the operation. Vascular access surgery provides excellent technical training for surgical trainees. The effect of surgical trainees on the outcome of fistulas was evaluated. METHODS: The grade of the main operator for all first attempted (primary) upper limb arteriovenous fistulas, between February 1998 and August 2001, was identified. Median follow-up was 18.0 months (IQR, 6.5-30.1 months). Successful use of fistula for dialysis, fistula patency and survival were assessed. RESULTS: 441 primary fistulas were formed in the study period. Median age was 67.5 years (IQR, 54.0-75.2 years). 71% of all fistulas were formed at the wrist. Trainees performed 31.1% of all operations. The two groups (trainees and consultants) were well matched for age, sex, diabetes, and fistula type. Only 70.5% of patients proceeded to long-term haemodialysis. There were no significant differences in the successful use of AVF for dialysis or patency rates between the two groups. One and two year fistula survival in this group was 87.7% and 78.3% for trainees and 80.8% and 71.1% for consultants (P = 0.288 log rank). CONCLUSIONS: Surgical trainees can perform primary AVF surgery without significantly reducing fistula outcomes. Vascular access surgery can be utilised as a training operation.

Knee scores in a 'normal' elderly population.

Many scoring instruments are now available for assessment of outcome after knee replacement. We performed a community study to record the three most frequently used knee scores in the UK in a 'normal' elderly population with no history of knee, hip, spine or lower limb disorder. The Oxford Knee Score (OKS), Bristol Knee Score (BKS), and American Knee Society Score (AKSS) were recorded in 100 volunteers whose mean age was 72 years. Normalised median scores in this population were 97% (42-100), 96% (69-100) and 98% (46-100), respectively. Significant negative correlations were found to exist between knee score and increasing age (P<0.001) and presence of coexistent 'major' medical conditions (P<0.001). The 'function' component of each score was the aspect of the score most influenced by these demographic variables. Comparison of outcomes after knee replacement on the basis of knee scores should take account of demographic variables.